Androgen binding protein

Laukaitis C.M., Critser E.S. and Karin R.C. (1997). Salivary androgen-binding protein (ABP) mediates sexual isolation in Mus musculus. Evolution 51, 2000-2005. 

The synthesis of the title compound, 214, the active-site-directed photoaffinity radiolabel for androgen-binding proteins ( ABP ), has been accomplished180,181 by treatment of excess 17a-[( )-2-tributyltin(IV)ethenyl]androsta-4,6-dien-17 -ol-3-one, 215, with sodium iodide-125 of specific activity 27 Cimmol-1 in a sodium acetate-AcOH buffered solution and a solution of 30% H2O2 in glacial AcOH (equation 77). 

FSH acts on testicular Sertoli cells to promote maturation of LH receptors and produce an androgen-binding protein. 

DNB came with the observation of significantly increased levels of androgen-binding protein (ABP, released from Sertoli cells) in seminiferous tubule fluid, interstitial fluid, and serum in rats treated with 15 and 32 mg/kg of 1,3-DNB, respectively (Reader et al. 1991 Rehnberg et al. 1988). Further examination of early toxic effects of 15 mg/kg of 1,3-DNB revealed vacuolization and cytoplasmic retraction in Sertoli cells within the first 24 hours after exposure (Blackburn et al. 1988). Similar observations of Sertoli cell damage were made when 1,3-DNB was administered at a dose of 30 mg/kg (Reader et al. 1991). Data from these studies support the notion that Sertoli cells may be first and primary targets of the toxic effects of 1,3-DNB in seminiferous epithelium. 

Sertoli cells, in the seminiferous tubule wall, are known to be important in spermatogenesis, in part through their synthesis of an androgen-binding protein (ABP). ABP, when secreted into the lumen of the seminiferous tubules, selectively binds testosterone of Leydig cell origin and serves as a hormone reservoir and transport protein for the androgen. 

FSH plays a key role in spermatogenesis it binds G-protein-coupled membrane-bound receptors on Sertoli cells and induces the Sertoli cells to proliferate during pre- and postnatal development. FSH also induces Sertoli cells to produce androgen binding protein (ABP), TGF-beta 1, MIS and other important signalling compounds. Sertoli cells also play an important role in spermiation and are the source of the seminiferous tubule fluid that provides nutrients to sperm cells as they travel from the testis to the epididymis. 

FSH, for example, increases the expression of a polypeptide known as androgen-binding protein (ABP). ABP helps concentrate testosterone within the seminiferous tubules and helps transport testosterone to the epididymis.39 FSH may also affect Leydig cell function indirectly by increasing the production of other chemical messengers from the Sertoli cells that enhance differentiation and function of Leydig cells.146 147... 

Abbreviations ABP, androgen-binding protein 5q-DHT. 5a-dihydrotestosterone 5/3-DHT, 5/3-dihy-drotestosterone EGF, epidermal growth factor FSH. folitropin KAP, kidney androgen-induced protein LH, lutropin NGF, nerve growth factor SGF, testis-specific growth factor. 

Perez-Infante V, Bardin CW, Gunsalus GL, Musto NA, Rich KA Mather JP (1986) Differential regulation of testicular transferrin and androgen binding protein secretion in primary cultures of rat Sertoli cells. Endocrinology 118 383-392. 

Adrenocorticotropic hormone Androgen binding protein Antidiuretic hormone (also known as VP)... 

Hammond, G.L. and W.P. Bocchinfuso. Sex hormone-binding globulin/androgen-binding protein steroidbinding and dimerization domains. J. Steroid Biochem. Mol. Biol. 53 543—552, 1995. 

Bardin, C. W, N. Musto, G. L. Gunsalus,N. Kotiten, S. L. Cheng, F. Larrea, and R. Becker. 1981. Extracellular androgen binding proteins. Annual Review of Physiology 43 189-198. 

Danzo, B. J., and D. R. Joseph. 1994. Structure-function relationships of rat androgen binding protein/human sex-hormone binding globulins The effect of mutagenesis on steroidbinding parameters. Endocrinology 135 157-167. 

Gunsalus, G. L., N. A. Musto, and C. W. Bardin. 1978. Androgen binding protein as a marker for Sertoh cell function. Journal of Steroid Biochemistry 15 99-106. 

Spitz, I. M., G. L. Gunsalus, J. P. Mather, R. Thau, and C. W. Bardin. 1985. The effects of imidazole carboxylic acid derivative, tohnidamine on testicular function. 1. Early changes in androgen binding protein secretion in the rat. Journal of Androgens 6 161-178. 

Sullivan, P.M., Petrusz, P., Szpirer, C. Joseph, D.R. (1991) J. Biol. Chem. 266, 143-154. Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. 

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