Follitropin alpha

The menotropins, human menopausal gonadotropin (HMG) and urofollitropin are prepared from the urine of postmenopausal women. HMG has approximately equal amounts of FSH an LH. Urofollitropin has only FSH activity. Follitropin alpha and follitropin beta are two FSH products which are made with recombinant DNA technology. Lutropin alpha is recombinant human LH. Human chorionic gonadotropin (HCG) is produced in the placenta and excreted in the urine. It has mainly LH activity. Choriogonadotropin alpha is the world s first recombinant chorionic gonadotropin (r-hCG) for the treatment of anovulation, the most common cause of infertility in women. 

Follitropin alpha, human follicle-stimulating hormone (hFSH), recombinant... 

FSH has been commercially available since the 1960s. It was first extracted from the urine of postmenopausal women, which contains a substance with FSH-like properties (but with 4% of the potency) and an LH-like substance. This purified extract of FSH and LH, derived from the urine of postmenopausal women, remains available and is known as menotropins, or human menopausal gonadotropins (hMG). A purified preparation of human FSH, also extracted from the urine of postmenopausal women, contains virtually no LH and is know as urofollitropin, or urinary FSH (uFSH). In 1996, a synthetic modified form of FSH became available, known as follitropin alpha, or recombinant FSH (rFSH). Preparations of rFSH have batch-to-batch consistency and are free from possible urinary contaminants. The cost of rFSH is about three times that of hMG. It is controversial whether in vitro fertilization protocols using rFSH are significantly more successful than protocols using uFSH or hMG. 

Antithrombotic agents alteplase, drotrecogin alfa, antithrombin III Antianemic darbopoetin alfa, erythropoietin Growth hormones follitropin alpha, follitropin beta, chorionic gonadotropin (Human)... 

Follicle-stimulating hormone (FSH) 4 Follistim 15, 465 Follistim AQ 465 Follitropin alpha 463 Follitropin beta 465 Fondapparin sodium 457 Food and dmg administration (FDA) 49, 1559, 1639, 1765... 

Gonadotropins—Follitropin Alpha (Gonal-F) and Follitropin Beta (Fllllstim)... 

LI. Landy, H., Schneyer, A. L., Whitcomb, R. W., and Crowley, W. F., Validation of highly specific and sensitive radioimmunoassays for lutropin, follitropin, and free alpha subunit in unextracted urine. Clin. Chem. 36, 340-344 (1990). 

Finland follitropin alfa protein Gonal-F Recombinant human FSH in its alpha glycoform expressed in CHO cells Hormone... 

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