Liver selenium

Valimaki, M., Alfthan, G., Pikkarainin, J., Ylikahri, R. and Salaspuro, M. (1987). Blood and liver selenium concentrations in patients with liver diseases. Clin. Chim. Acta 166, 171-176. 

Alfthan G, Penttila A. 1988. Effect of fat on human liver selenium concentration. Biol Trace Elem Res 18 137-143. 

Crespo AM, Neve J, Pinto RE. 1993. Plasma and liver selenium levels in the rat during supplementation with 0.5, 2, 6, and 15 ppm selenium in drinking water. Biol Trace Elem Res 38 139-146. 

Baker, M. A. and Tappel, A.L. (1986) Effect of gold thioglucose on subcellular selenium distribution in rat liver and kidney. Biological Trace Element Research, 9, 113-123. 

There is very little evidence relating to the role of ROMs in cholestatic liver disease. Serum selenium and glutathione peroxidase activity are decreased in humans with intrahepatic cholestasis of pregnancy (Kauppila et al., 1987). Low levels of vitamin E have been reported in patients with primary biliary cirrhosis, and in children with Alagille s syndrome or biliary atresia (Knight et al., 1986 Jeffrey etal., 1987 Lemonnier etal., 1987 Babin etal., 1988 Kaplan et al., 1988 Sokol etal., 1989). Serum levels of Mn-SOD are increased in patients with all stages of primary biliary cirrhosis compared with patients with other forms of chronic liver disease, although whether this causes or results from the disease process is unclear (Ono etal., 1991). 

Aaseth, J., Alexander, J., Thomassen, Y., Blomhoff, J.P. and Skrede, S. (1983). Serum selenium levels in liver diseases. Clin. Biochem. 15, 281-283. 

Dworkin, B., Rosenthal, W.S., Jankowski, R.H., Gordon, G.G. and Haldea, D. (1985). Low blood selenium levels in alcoholics with and without advanced liver disease. Correlation with clinical and nutritional status. Dig. Dis. Sci. 30, 838-844. 

Johansson, V., Johnsson, F., Joelsson, B., Beiglund, M. and Akesson, B. (1986). Selenium status in patients with liver cirrhosis and alcoholism. Br. J. Nutr. 55, 227-233. 

Korpela, H., Kumpulainen, J., Luoma, P.V., Arranto, A.J. and Sotaniemi, E.A. (1985). Decreased serum selenium in alcoholics as related to liver structure and function. Am. J. Clin. Nutr. 42, 147-151. 

Valimaki, M.J., Harju, K.J. and Ylikahri, R.H. (1983). Decreased serum selenium in alcoholics - a consequence of liver dysfunction. Clin. Chim. Acta 130, 291-296. 

The effects of antioxidants on protein oxidation were also studied in animal experiments. Barja et al. [73] demonstrated that feeding guinea pigs with vitamin C decreased endogenous protein oxidative damage in the liver. Administration of the mixture of antioxidants containing Trolox C, ascorbic palmitate, acetylcysteine, (3-carotene, ubiquinones 9 and 10, and (+)-catechin in addition to vitamin E and selenium to rats inhibited heme protein oxidation of kidney homogenates more efficiently than vitamin E + selenium [74]. 

Jorhem, L., B. Sundstrom, C. Astrand, and G. Haegglund. 1989. The levels of zinc, copper, manganese, selenium, chromium, nickel, cobalt, and aluminium in the meat, liver and kidney of Swedish pigs and cattle. Zeit. Lebens.-Unters. -Forschung 188 39-44. 

Nielsen, C.O. and R. Dietz. 1990. Distributional pattern of zinc, cadmium, mercury, and selenium in livers of hooded seal (Cystophora cristata). Biol. Trace Elem. Res. 24 61-71. 

Drinking water of weanling males contained 150 mg CN/L for 9 weeks Significant reduction in glutathione activity, and in selenium concentrations in blood, kidney, liver, and muscle 35... 

Elevated selenium concentrations were measured in tissues and diet of two captive California sea lions (Zalophus californianus) that died shortly after performing at a show in 1988. Selenium concentrations, in mg/kg FW, were 49 and 88 in liver, 42 and 47 in kidney, and 5.1 and 5.2 in blood. Selenium concentrations in their fish diet was 2.5 mg/kg FW, and in thawed fish fluids 45 mg/kg FW (Alexander et al. 1990). 

Selenomethionine group had altered immune function, altered serum enzyme activities, and elevated concentrations of selenium in liver (4 times control values) and breast muscle (14 times). Sodium selenite-treated birds had normal immune function and selenium tissue burdens however, serum enzyme activity was disrupted in the 3.5 mg/L group Adults normal. Impaired reproduction (reduced survival of ducklings, increased developmental abnormalities) for selenomethionine occurs between 4 and 8 mg/kg ration selenocysteine did not impair reproduction at 16 mg Se/kg ration... 

---