Selenium liver content

In past years, on line chromatographic coupling techniques such as HPLC and CE coupled to ICP-MS with the isotope dilution technique have been used for element quantification in speciation analysis. An interesting application of the isotope dilution technique in medical research was proposed recently by Prange and co-workers, who added highly enriched " S, Cu, Zn and Cd spikes to the interface of the CE-ICP-MS system. The authors separated isoforms of metallothionein (e.g., of rabbit liver) by capillary electrophoresis and quantified S, Cd, Cu and Zn concentrations in isoforms by ICP-SFMS using the isotope dilution technique. A new selenized yeast reference material (SELM-1) for methionine, selenomethionine (SeMet) and total selenium content has also certified by an intercomparison exercise. ... 

Using the granuloma-pouch technique, Roberts demonstrated that certain liver fractions in doses of 200 mg/rat intraperitoneally effectively reduce exudate volume . Three of six liver preparations proved to be active, as did the ash of one of these. It was later shown that the selenium content of... 

Tiran, B., Karpf, E., Tiran, A., 1995. Age dependency of selenium and cadmium content in human liver, kidney, and thyroid. Arch. Environ. Health 50, 242-246. 

The two types of casein used in our cod liver oil diets contained 0.450 and 0.270 ppm, respectively, of selenium. When these caseins were given at the 30% level, their selenium contents were apparently high enough to prevent the accumulation of exudates when the diets were fat free, but not when the diet contained 5 or 10% cod liver oil. Of the two caseins, the one with only 0.270 ppm of selenium was decidedly better than the other for producing exudates with cod liver oil diets. 

Differences in the selenium content of foodstuffs are due in part to geographical differences in the amounts of the element that are transferred from soil to the food chain. Selenium-deficiency diseases related to selenium-poor soil are recognized in parts of China and elsewhere, but soils rich in selenium (above 5 ppm) are found in parts of the United States. The selenium in most plant-derived foods, present substantially as selenomethionine (SeMet) and selenocysteine (SeCys) derivatives, has reasonably good bioavailability. However, in animal-derived foods selenium has a wide range of bioavailability as assessed by its ability to increase liver concentrations and glutathione peroxidase activity. 

There is substantial evidence that some animals may accumulate mercury and selenium at molar increment ratios in their tissues. When doses of mercury and selenium are varied in rats, the molar ratios of these elements in a plasma protein remained fairly close to unity (Burk et al., 1974). The selenium content of high mercury tuna was observed to be greater than in low mercury tuna (Ganther and Sunde, 1974). On a molar basis, selenium increases in an approximate 1 1 ratio with mercury. Mercury levels in the livers of 56 specimens of nine different species of marine mammals were highly correlated (r 0.99) with their selenium content, and 1 1 mercury-selenium molar increment ratios were found (Koeman et al., 1975). The authors suggested that marine mammals are... 

Silver accumulated in the liver with each increase of dietary silver, and this significantly increased hepatic copper and iron content (Table VI). However, silver had no influence on the zinc content of the liver. Dietary selenium significantly increased the silver content of the liver, consistent with the results of Wagner et al. (1975). The metabolic interaction of silver with copper in the rat is in agreement with findings by others using the chick (Hill et al, 1964 Peterson and Jensen, 1975b). 

Slightly different effects of silver on the renal mineral content were observed (Table VII). In contrast to the liver, silver had no significant effect on renal copper and iron levels. As for the liver, silver had no effect on renal zinc levels. Also consistent with the liver, silver accumulated in the kidneys, and selenium caused a significant increase in this accumulation. However, in contrast to the liver, there was a significant interaction between selenium and silver with respect to the accumulation of silver in this organ. This indicates that only a combination of selenium and silver brings about this effect. 

Lewis CD, Laemmli UK (1982) Higher order metaphase chromosome structure evidence for metalloprotein interactions. Cell 29 171-181 Li NQ, Reddy PS, Thyagaraju K, Reddy AP, Hsu BL, Scholz RW, Tu CP, Reddy CC (1990) Elevation of rat liver mRNA for selenium-dependent glutathione peroxidase by selenium deficiency. J Biol Chem 265 108-113 McArdle HJ, Mercer JF, Sargeson AM, Danks DM (1990) Effects of cellular copper content on copper uptake and metallothionein and ceruloplasmin mRNA levels in mouse hepatocytes. J Nutr 120 1370-1375... 

Selenium—Meat, poultry, and fish all contain small amounts of selenium, but liver and kidney are the best sources. The selenium content of animal products depends upon the content of the element in livestock feeds for example, the Ohio Station reported that the addition of 0.1 ppm selenium to the animal s diet increeised the selenium content of beef liver by 72%. ... 

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