Liver damage

Heptachlor zero 0.0004 Liver damage risk of cancer Residue of banned termiticide 

Heptachlor epoxide zero 0.0002 Liver damage risk of cancer Breakdown of hepatachlor 

Grade 0, LDjq > 15 g/kg Late Toxicity Liver damage in rats (from addition of oil to diet) Vapor (Gas) Irritant Characteristics Data not available Liquid or Solid Irritant Characteristics Data not available Odor Threshold Data not available. 

A. Hepatotoxiiis Chemicals which produce liver damage  

IIBI TABLE 5.15 Chemical Compounds that Induce Acute Liver Damage 

Class and Definition Hepatotoxins - produce hepatic (liver) damage 

Ulll TABLE S. 14 Chemical Compounds that Induce Chronic Liver Damage 

A Mutant Protein That Folds Slowly Can Cause Emphysema and Liver Damage 

TABLE 5.13 Examples of Drugs that Induce Intrahepatic Cholestasis or Liver Damage Resembling That Induced by Viral Hepatitis 

Toxicity. Injection of aq Na perchlorate into rabbits caused no long term toxic effects. It behaved as a mild muscular poison, and large doses caused liver damage and diarrhea. Goldfish will live indefinitely in a 0.1% soln, but a 1% soln will cause asphyxia (Ref 4) 

The naproxen that you buy over the counter at your local pharmacy consists of a single enantiomer, which is an effective analgesic (pain killer). The other enantiomer is not a pain killer even worse, it can cause liver damage. 

Toxicity. Many /V-nitrosamines are toxic to animals and cells in culture (4,6—8,88). /V-Nitrosodimethy1amine [62-75-9] (NDMA) is known to be acutely toxic to the Hver in humans, and exposure can result in death (89). Liver damage, diffuse bleeding, edema, and inflammation are toxic effects observed in humans as a result of acute and subacute exposure to NDMA. These effects closely resemble those observed in animals dosed with NDMA (89,90). 

Since no specific antidotes are known, symptomatic therapy must be accompanied by complete rest. Toxicity by Inhalation (ThresholdUmit Value)-. 0.5 mg/m Short-Term Exposure Limits 2 mg/m for 30 min Toxicity by Ingestion oral LD, = 283 mg/kg (rat) Late Toxicity Possible liver damage loss of appetite or weight. Vapor (Gas) Irritant Characteristics No data Liquid or Solid Irritant Characteristics No data Odor Threshold No data. 

A second problem concerns delimiting the mechanisms of action which should be included in the definition, to exclude effects which are a secondary consequence of overt toxicity in other body systems. For example, disruption to the endocrine system caused by general metabolic disturbance, such as in severe liver damage, should not be grounds for calling a chemical an ED. 

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