Anemia with liver damage

Properties Yel. monoclinic cryst. sol. in acetone, benzene insol. in water m.w. 288.13 dens. 1.762 g/ml (12 C) m.p. 192-195 C b.p. explodes Toxicology Toxic may cause skin/eye irritation, headache, drowsiness, weakness, cyanosis, respiratory distress chronic exposure may cause wt. loss, anemia, possible liver damage Precaution Probably combustible dangerous, explodes by heat or shock reacts with oxidizing materials... 

Megaloblastic Anemias Associated with Liver Damage. 194... 

In Nigeria, macrocytic anemia in pregnant Africans was associated with liver damage and a macronormoblastic blood picture. During pregnancy there was usually no response to folic acid or vitamin Bx2, but after... 

Cats exposed to 9000 ppm for 8 hours suffered irritation and labored breathing 20,000 ppm for 45 minutes caused deep narcosis, and 43,000ppm for 14—16 minutes was fatal at autopsy, findings were pulmonary edema with hemorrhage and hyperemia of the respiratory tract. Repeated exposure of rabbits to 4450 ppm resulted in secondary anemia with leukocytosis, hyperemia, and damage to the liver. ... 

Other effects reported in tetryl workers are irritability, fatigue, malaise, headache, lassitude, insomnia, nausea, and vomiting. Anemia, of either the marrow depression or deficiency type, has been observed among tetryl workers. Conjunctivitis may be caused by rubbing the eyes with contaminated hands or by airborne dust keratitis and iridocyclitis have occurred. Tetryl has been reported to cause irreversible liver damage and death after chronic heavy exposure." However, complicat-... 

Deaths Deaths associated with the administration of sulfasalazine have been reported from hypersensitivity reactions, agranulocytosis, aplastic anemia, other blood dyscrasias, renal and liver damage, irreversible neuromuscular and CNS changes, and fibrosing alveolitis. If toxic or hypersensitivity reactions occur, discontinue sulfasalazine immediately. 

Phenylbutazone (Butazolidin) is metabolized to oxy-phenbutazone (Phlogistol), and both compounds have all of the activities associated with the NSAIDs. Their use is accompanied by serious adverse reactions, such as anemia, nephritis, renal failure or necrosis, and liver damage. Because of their toxicity, they are prescribed only for the treatment of pain associated with gout or phlebitis or as a last resort for other painful inflammatory diseases resistant to newer and less toxic treatments. Interactions with a large number of other drugs... 

Red phosphorus is not considered to be harmful physiologically. White phosphorus burns the skin and eyes and causes severe internal damage if swallowed. The vapor from burning phosphorus irritates the respiratory system and eyes. Prolonged absorption of small quantities results in anemia, intestinal weakness, and bone and liver damage. Avoid contact with skin and eyes.3 TLV-TWA (yellow phosphorus) 0.1 mg/m3.30... 

The toxic effects of lindane are very similar to those of DDT. Degeneration of kidney tubules, liver damage associated with fatty tissue, and hystoplastic anemia have been observed in individuals poisoned by lindane. 

Hepatotoxic chemicals cause liver damage, jaundice, and liver enlargement. Nephrotoxic chemicals cause kidney damage and renal failure. Hematopoietic chemicals interfere with the production of red blood cells and can cause anemia and leukemia. 

In occupationally exposed humans, chloracne, dermal effects and liver damage are the most common health effects. Some cases with fatal outcome have been reported. Symptoms of PCN poisoning include jaundice, constipation, abdominal pain, abdominal distension, anorexia, nausea, vomiting, anemia, skin problems, eye irritation, headache, fatigue and vertigo. Some of the toxic effects persisted for a long period after the exposure had ceased. In severe cases the patients died [1, 27, 264-266], Studies of experimentally induced chloracne show that tetra-, penta-, and hexaCNs have acnegenic properties when applied on the human skin [263,267]. 

Co-trimoxazole should not be given to patients with malnutrition, pregnancy, severe liver damage, megaloblastic anemia, agranulocytosis, or bone marrow failure (12,14,87). 

Prolonged and/or repeated skin contact may result in dermatitis and may cause eye irritation and corneal injury. Chronic exposure may cause kidney and liver damage, anemia, stomach pains, vomiting, diarrhea, blood disorders, and cardiovascular effects if RP is contaminated with WP. 

What this means is that commonly reported occurrences to glue sniffers, such as liver damage, impairment of production of red blood cells from bone marrow, and anemia, have been exaggerated to a certain extent. They ere possible, but only with repeated use, apparently. What the reader must keep in mind is that frequent glue sniffers do develop a tolerance to... 

Hemolytic anemia, rash, and liver damage may occur even with normal doses. In cases of overdosage, headache, vomiting, insomnia, and tachycardia are possible. Reactions may occur in leprosy with or without therapy. In lepromatous leprosy there is erythema nodosum, fever, and in some cases severe malaise. In tuberculoid leprosy the pain increases. About 50% of the treated patients with lepromatous leprosy show erythema nodosum within the 1st year, lasting for 2 weeks. As a rule, therapy with sulfones in combination with clofazimine may be continued in spite of the erythema nodosum. Analgetics, corticosteroids, and thalidomide are suitable for the treatment of leprosy reactions (Rea and Levan 1975). 

In relation to the administration of medicines for animals, the pharmacological differences and local laws have to be observed. The pharmacokinetics of every active substance is different in each species. For anunals, especially cats, the toxic concentration of many human medicines is lower than the therapeutic dose in humans due to differences in metabolism of medicines. For example, in cats, the administratirm of acetaminophen (paracetamol) very quickly leads to intoxication with methemoglobin formation, anemia, hemoglobinuria and liver damage, as they may metabolise the medicine poorly. 

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