Beneficial effects against liver damage

An important compound with biological activity of clavines is represented by 6 as end product of EA biosynthesis in A. fumigatus. In animal experiments using rats, 6 exhibited vasorelaxant effects on isolated thoracic aortic rings independent of endothelial mediators. Several mechanisms are proposed for the vasorelaxant effect of 6. These results indicate that 6 has potential capacity in vascular protection and may be used as therapeutic dmg against cardiovascular diseases [78]. Treatment of mice with induced liver damage and colitis with 6 showed clear beneficial effects on these diseases [79, 80]. In addition, it has also been demonstrated that 6 exhibits potential relevance as an antiatherosclerotic agent. Inflammation processes like activation of toll-like receptor 4 (TLR 4) and nuclear factor kB (NFkB) have been shown to be responsible in the development... 

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