Drug-induced liver damag

Table 5. Drug induced liver damage, some well-described varieties...

Hartleb M, Biernat L, Kochel A. Drug-induced liver damage—a three-year study of patients from one gastroenterological department. Med Sci Monit 2002 8(4) CR292-6. 

Tarkan, L., F.D.A. increases efforts to avert drug-induced liver damage, New York Times, Aug. 14, 2001, p. D5. 

In drug-induced liver damage, a similar immunological mechanism is conceivable the respective medicament acts as a hapten, and an endogenic protein turns into an autoantigen. In hypersensitivity reactions, IgE can increase. 

The pathogenesis of drug-induced liver damage is an individual, albeit multifactorial process. The main mechanisms known to date include ... 

Cortex Dictamnus dasycarpus (bai xian pi) and Radix Sophora flavescens (ku shen), is commonly used to treat hematochezia, anal bulge, and constipation caused by hemorrhoids. The State Food and Drug Administration of China (SFDA) has received several reports of adverse reactions to Zhi xue capsule in recent years [7, 8 ]. Up to September 2008, 35 cases of adverse reactions associated with Zhi xue capsule had been reported, of which 21 were associated with abnormal liver function, cholestatic hepatitis, and drug-induced liver damage. After withdrawal and symptomatic treatment, there was full recovery in eight cases, and the rest improved markedly. 

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