Lipoprotein metabolism, effect

Packard, CJ. and Shepherd, J. 1982. The hepatobiliary axis and lipoprotein metabolism Effects of bile acid sequestrants and ileal bypass surgery. J. Lipid Res. 23, 1081-1098. 

Berge, R.K. Hvattum, E. (1994). Pharmac. Ther. 61(3) 345-383. Impact of cytochrome P450 system on lipoprotein metabolism. Effect of abnormal fatty acids (3-Thia fatty acids). 

Apolipoprotein AIV (apo AIV) is produced in the intestine and is found in chylomicrons, VLDL and HDL. It may modulate enzymes involved in lipoprotein metabolism and may serve as a saturation signal [49]. In a study with 144 participants the apo AIV His360Glu polymorphism showed no significant effect on cholesterol lowering in response to statin therapy [50]. 

De Bruin, T. W. A., C. B. Brouwer, M. L. S. Trip, H. Jansen, and D. W. Erkelens. Different postprandial metabolism of olive oil and soyean oil a possible mechanism of the high-den-sity lipoprotein conserving effect of olive oil. Amer J Clin Nutr 1993 58(4) 477-483. 

Lipid metabolism effects. Grains, in the ration of rats at a dose of 68 g/animal daily for 3 months, were active vs rats fed tapioca. Total serum cholesterol and triglycerides were higher than animals fed tapioca. Glucose-6-phosphate levels were lower, and triglyceride lipase and lipoprotein lipase were increased over levels found in the tapioca group k Seed oil, in the ration of rats at a concentration of 10% of the diet, was active. Liver triglycerides were lower in rats fed rice brain oil than those fed peanut... 

Jenkins DJ, Kendall, CW, Vidgen E et al. Effect of soy-based breakfast cereal on blood lipids and oxidized low-density lipoprotein. Metabolism 49, 1496-1500, 2000. 

The effect of di(2-ethylhexyl) phthalate in diet (2% for 21 days) on lipoprotein metabolism in male Wistar rats was evaluated (Mocchiutti Bernal, 1997). The observed reduction in plasma triglyceride levels was associated with (and attributed to) increased activity of extrahepatic lipoprotein lipase. 

Metabolic effects of tumor necrosis factor alfa include a reduction in cholesterol and high-density lipoproteins, increases in triglycerides and very low-density lipoproteins, and hyperglycemia. 

F6. Falko, J. M., Schonfeld, G., Witztum, J. L., Kolar, ]. B., and Salmon, P., Effects of short-term high carbohydrate, fat-free diet on plasma levels of Apo C-II and Apo C-III and on the ApoC subspecies in human plasma lipoproteins. Metabolism 29, 654-661 (1980). 

Gylling, H. and Miettinen, T.A. 1996. Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men. J. Lipid Res. 37, 1776-1785. 

Fernandez ML (2001) Guinea pigs as models for cholesterol and lipoprotein metabolism. J Nutr 131 10-20 Gaertner K (2001) The forestomach of rats and mice, an effective device supporting digestive metabolism in muridae (Review). J Exp Anim Sci 42 1-20... 

Individuals suffering from diabetes mellitus, hypothyroidism or kidney disease often exhibit abnormal lipoprotein metabolism as a result of secondary effects of their disorders. For example, because LPL synthesis is regulated by insulin, LPL deficiencies leading to type I hyperlipopro-teinaemia may occur as a secondary outcome of diabetes mellitus. 

Taylor AH, et al. Beneflcial effects of a novel thyromimetic on lipoprotein metabolism. Mol. Pharmacol. 1997 52 542-547. Ocasio CA, Scanlan TS. Design and characterization of a thyroid hormone receptor alpha (TRalpha)-speciflc agonist. ACS Chem. Biol. 2006 1 585-593. 

Although its role in lipoprotein metabolism has not been delineated fully, recent studies clearly imply that LRP is responsible for the clearance of a significant percentage of chylomicron remnants (Hussain et al., 1991 Mahley and Hussain, 1991). The interaction of apoE with the LRP has been most extensively studied using rabbit jS-VLDLs (Kowal et al., 1989, 1990). These cholesterol-enriched lipoproteins represent chylomicron remnants derived from the intestine and VLDL remnants from the liver. They contain multiple apoE molecules in addition to apoB and the low molecular weight apoC molecules. Interestingly, for rabbit )8-VLDLs to interact effectively with the LRP receptor, the apoE content of these lipoproteins must be first enriched by incuba-... 

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