Liver triglycerides

Dibromoethane is considered to be a weak hepatotoxin in animals. Hepatocellular fatty change (degeneration) is one of the common lesions in experimental animals associated with acute oral exposure to 1,2-dibromoethane (Botti et al. 1986). When administered to rats by gavage at a dosage of 110 mg/kg/day, this lesion is corroborated by an increase in liver triglyceride levels that begins within 8 hours of treatment (Nachtomi and Alumot 1972). 

Lipid metabolism effects. Grains, in the ration of rats at a dose of 68 g/animal daily for 3 months, were active vs rats fed tapioca. Total serum cholesterol and triglycerides were higher than animals fed tapioca. Glucose-6-phosphate levels were lower, and triglyceride lipase and lipoprotein lipase were increased over levels found in the tapioca group k Seed oil, in the ration of rats at a concentration of 10% of the diet, was active. Liver triglycerides were lower in rats fed rice brain oil than those fed peanut... 

Figure 2.2 Increase in liver weight and liver triglycerides caused by hydrazine. Source. From Ref. 3.

Oral administration of isopropanol increased the hepatotoxicity of chlorinated hydrocarbons in mice and led to accumulation of liver triglycerides in rats (lARC, 1977). 

Phospholipids are considered to be involved in the transport of triglycerides through die liver, especially during mobilization from adipose tissue, Conditions which could be interpreted as interfering with phosphatidylcholine formation, such as deficiency of choline or its precursors, result in a pronounced increase 111 liver triglycerides. 

Twelve hours after ingestion of a single dose of white phosphorus, significant increases in liver triglyceride and decreases in plasma triglyceride levels were observed (Ghoshal et... 

A metabolic product of fiber fermentation, propionate may mediate some of the hypocholesterolemic effects of certain soluble plant fibers. In cholesterol-fed rats, propionate decreases serum cholesterol and liver triglyceride level where no changes in hepatic histology in response to propionate intake have been detected (Wang and Ng, 1999). 

Table 4 Effect of liver triglycerides and alanine aminotransferase blood levels on diet-induced obesity in mice using Entry 1 at lOmg/kg per day...

Table 3. Effects of chitosan on liver triglyceride (TG) and total cholesterol (TC) in mice fed a high-fat diet for 9 weeks...

M (increased relative liver weight and liver triglycerides)... 

The lowest reported hepatic effect levels in intermediate-duration oral studies are NOAELs for microsomal enzyme induction in rats (Bruckner et al. 1974,1977 Litterst et al. 1972). Liver microsomal nitroreductase and demethylase were induced in rats that were fed 6.03 mg/kg/day (lowest tested dose) Aroclor 1242, 1248,1254, or 1260 for 4 weeks (Litterst et al. 1972). All of these PCB mixtures also caused increased relative liver weight at 2.5 mg/kg/day and increased liver triglycerides at 25 mg/kg/day however, histology was not evaluated. The effects were generally dose-related among... 

Mice exposed to 800 ppm of 1,1,2-trichloroethane for 3 hours had decreased adenosine triphosphate (ATP), increased liver triglycerides, decreased plasma triglycerides, and increased SGPT (Takahara 1986c). Recovery occurred within 20 hours for all parameters except SGPT, which remained elevated. The ETsofor increased SGPT levels in mice exposed to 3750 ppm of... 

LIVER TRIGLYCERIDES LOWERING EFFECTIVE HIGHLY EFFECTIVE... 

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