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On-target pharmacology

Fig. 3 Tissue-organ distribution in adverse pharmacology. On-target pharmacology can result in adverse effects if engagement of the target is in the wrong or inappropriate tissue... Fig. 3 Tissue-organ distribution in adverse pharmacology. On-target pharmacology can result in adverse effects if engagement of the target is in the wrong or inappropriate tissue...
Clinical pharmacology Denileukin diftitox is a fusion protein designed to direct the cytocidal action of diphtheria toxin to cells that express the IL-2 receptor. It binds avidly to the high-affinity interleukin-2 receptor on target-cell surfaces, where it is... [Pg.202]

Name Main Molecular Target Pharmacology Effect on Dopamine (DA) Neurons RR2... [Pg.715]

As noted above, in vivo pharmacological studies with selective Cav3 blockers have not yet been reported extensively. Consequently, most of the results reported to date use either mibefradil or ethosuximide and while the data are solid, the on-target mechanistic interpretation of the results must be... [Pg.46]

See other pages where On-target pharmacology is mentioned: [Pg.17]    [Pg.45]    [Pg.237]    [Pg.50]    [Pg.70]    [Pg.17]    [Pg.45]    [Pg.237]    [Pg.50]    [Pg.70]    [Pg.117]    [Pg.168]    [Pg.189]    [Pg.169]    [Pg.185]    [Pg.58]    [Pg.25]    [Pg.177]    [Pg.903]    [Pg.222]    [Pg.341]    [Pg.581]    [Pg.108]    [Pg.113]    [Pg.118]    [Pg.249]    [Pg.288]    [Pg.295]    [Pg.110]    [Pg.154]    [Pg.181]    [Pg.10]    [Pg.19]    [Pg.60]    [Pg.62]    [Pg.166]    [Pg.238]    [Pg.391]    [Pg.363]    [Pg.559]    [Pg.610]    [Pg.31]    [Pg.491]    [Pg.407]    [Pg.393]    [Pg.249]    [Pg.109]    [Pg.669]    [Pg.22]    [Pg.58]    [Pg.82]    [Pg.118]   
See also in sourсe #XX -- [ Pg.50 ]



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On-target

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