Lipid levels management

The expected outcomes for die patient may include a dierapeutic response to dierapy (lowered blood lipid levels), management of common adverse drug reactions, and an understanding of die dietary measures necessary to reduce lipid and lipoprotein levels. 

Because of the polyfactorial nature of disease states, such as obesity, type 2 diabetes, and Metabolic Syndrome, it is expected that drugs targeting the lipid synthesis and metabolism pathways will be used in the context of combination therapy [7]. Pre-clinical and clinical results to date indicate that pronounced efficacy could be achieved toward the management of associated lipid levels and insulin resistance, and thus, investigation in these areas provides significant promise. 

Cardiovascular diseases are a major cause of death in developed countries, making prevention a priority for public health policy. Research evidence over years has shown that cardiovascular diseases can be managed and even prevented by healthful eating practices involving a resveratrol-enriched diet of whole plant foods such as offered by superfruits. For more than fifty years, research has shown that a healthful, active lifestyle combined with the dietary benefit of high fruit and vegetable intake may lower blood lipid levels, blood pressure, and risk of coronary heart disease and stroke. 

CHD or CHD equivalents. Specific models for therapeutic life-style changes and drug therapy in the primary prevention of CHD have been recommended by ATP III (Figures 26-23 and 26-24). As for the management of patients with metabolic syndrome, a combination approach of weight reduction, increased physical activity, and appropriate control of lipid levels is recommended. 

Drugs can be used to lower lipid levels, but changes in diet and control or elimination of other risk factors play an important role in the management of hyperiipidaemia. 

Prazosin may be particularly useful when patients cannot tolerate other types of antihypertensive agents or when blood pressure is not well controlled by other drugs. Since prazosin does not significantly influence blood uric acid or glucose levels, it can be used in hypertensive patients whose condition is complicated by gout or diabetes meUitus. Prazosin treatment is associated with favorable effects on plasma lipids. Thus, it may be of particular importance in managing patients with hyperlipidemia. 

Disruption of lipid metabolism as the cause of respiratory distress syndrome and Tay-Sachs disease Section 26.1.6 Diagnostic use of blood cholesterol levels Section 26.3.2 Hypercholesteremia and atherosclerosis Section 26.3.5 Clinical management of cholesterol levels Section 26.3.6... 

The compositional characteristics of almond oil show that it is rich in several health-promoting nutrients, many of which may be responsible for the observed benehcial effects of dietary almond consumption in cardiovascular diseases (11) and in weight management (12), however, few investigations have explored this topic. Hyson et al. (13) conducted a dietary intervention study to determine whether the consumption of whole almonds or almond oil for 6 weeks would result in similar or different effects on plasma lipids and ex vivo LDL oxidation. Both groups consumed diets with identical almond oil and total fat levels. This study showed that both whole almond and almond oil consumption caused similar reductions in plasma cholesterol and LDL (4% and 6%, respectively) as well as a 14%... 

The ocular bioavailability of topical glucocorticoid formulations varies significantly. Lipid-soluble alcohol and ester preparations penetrate intact conjunctival and corneal epithelium readily and rapidly reach therapeutic levels in the anterior chamber of the normal eye. Water-soluble phosphate preparations are retarded by intact corneal epithelium in the normal eye and are generally used in the management of ocular surface disease. However, it has been shown in experimental animals that the intraocular levels of topically applied prednisolone phosphate exceed that of the acetate preparation in the acutely inflamed eye. 

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