Prednisolone phosphate

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Suspension. If the drug is not sufficiently soluble, it can be formulated as a suspension. A suspension may also be desired to improve stability, bioavailability, or efficacy. The major topical ophthalmic suspensions are the steroid anti-inflammatory agents prednisolone acetate, dexamethasone, fluorometholone, and rimex-olone. Water-soluble salts of prednisolone phosphate and dexamethasone phosphate are available however, they have a lower steroid potency and are poorly absorbed. 

Musson, D., Bidgood, A., and Olejnik, 0. In vitro penetration and metabolism studies of prednisolone phosphate, disodium and prednisolone acetate across the cornea of rabbits. Pharm. Res. 6(suppl) S175, 1989. 

Prednisolone phosphate eye drops are very photosensitive when packaged in clear colorless glass ampoules as well as in uncolored, high-density polyethylene containers. When exposed to UV and VIS radiation, the drug substance is completely decomposed within a few hours. However, packaging the prednisolone phosphate solution in brown glass vials, results in satisfactory UV-VIS photo protection (6) as shown in Figure 2. 

Figure 2 Photostability of prednisolone phosphate-eye drops (0.13% FNA, Formularium der Nederlandse Apothekers) stored in different types of containers in the Novasoltest light testing cabinet. ( ) brown glass containers, ( ) uncolored high-density polyethylene containers, (o) clear glass ampoules. Source Ref. 6.

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