Lipid levels, blood

Table 2 Summary of investigations into the effeet of soya or linseed on blood lipid levels in men and women...

Thus, it is apparent that soya, some soya products and linseed oil influence blood lipid levels, particularly cholesterol and LDL cholesterol. While the extent of the reduction appears to largely depend on an individual s initial serum cholesterol level, the maximum reductions observed are of the order of 10-15%. For hyperlipidemic individuals this may not be a marked reduction, but such an effect on the general population may well have a beneficial effect on the overall incidence of cardiovascular disease and atherosclerosis. The possibility that non-phytoestrogenic dietary components may contribute to the hypocholes-terolemic properties cannot, however, be discounted. Indeed, certain types of dietary fibre have been shown to have a hypolipidemic effect via their ability to increase faecal excretion rates. 

Sometimes a paradoxical elevation of blood lipid levels occurs Should this happen, the primary health care provider is notified because the primary health care provider may prescribe a different antihyperiipidemic drug. 

The expected outcomes for die patient may include a dierapeutic response to dierapy (lowered blood lipid levels), management of common adverse drug reactions, and an understanding of die dietary measures necessary to reduce lipid and lipoprotein levels. 

Table 10.7 Cytochrome P450 2D6 (CyP2D5)-related blood lipid levels in Alzheimer s disease...

Although nicotinic acid and nicotinamide function identically as vitamins, their pharmacologic effects differ. In large doses (up to 6 g/day), nicotinic acid is effective in reducing serum lipids (low-density lipoprotein [LDL], high-density lipoprotein [HDL], triglycerides, and lipoprotein A. Nicotinic acid produces vasodilation and increased blood flow due to histamine release. Nicotinamide does not affect blood lipid levels or the cardiovascular system. 

The next example is the ethyl ester of, and precursor to, cetaben, a drug that can be used to lower blood lipid levels. It is an amine, so we disconnect next to the nitrogen atom, cetaben ethyl ester ... 

Microalbuminuria Close monitoring of blood pressure, blood glucose and blood lipid levels Monitor urinary protein Aim for BP <125/75 mmHg Add further antihypertensive drugs if necessary Add ACE I/ARB if possible Aim for total cholesterol <3.5 mmol/L... 

The hypothyroid condition is associated with increased blood lipid levels, which can be treated using statins or cholesterol binding resins such as colestyramine. 

The discovery of the statin mevalonic acid synthesis inhibitors focused new attention on control of blood lipid levels as a measure to stave off heart disease. A number of compounds have been found that treat elevated lipid levels by other diverse mechanisms. The phosphonic acid derivative ibrolipim (9) is believed to lower those levels by accelerating fatty acid oxidation. The phosphoms-containing starting material 7 can in principle be obtained by the Arbuzov reaction of a protected from of p-bromomethylbenzoic acid (6) with triethyl phosphate. Removal of the protecting group and conversion of the acid to an acyl chloride then affords 7. Condensation of this intermediate with substituted aniline 8 leads to the hypolipidemic agent (9). ... 

Cardiovascular diseases are a major cause of death in developed countries, making prevention a priority for public health policy. Research evidence over years has shown that cardiovascular diseases can be managed and even prevented by healthful eating practices involving a resveratrol-enriched diet of whole plant foods such as offered by superfruits. For more than fifty years, research has shown that a healthful, active lifestyle combined with the dietary benefit of high fruit and vegetable intake may lower blood lipid levels, blood pressure, and risk of coronary heart disease and stroke. 

Monitor for hyperlipidemia (elevated blood lipid levels). 

Wren BG, Champion SM, Manga RZ, Eden JA. Transdermal progesterone and its effect on vasomotor symptoms, blood lipid levels, bone metabolic markers, moods, and quality of life for postmenopausal women. Menopause 2003 10 13-18. 

Net Gastrointestinal Absorption or Excretion of PCBs in Humans and Dependence on Congener-Specific Blood Lipid Levels... 

The therapeutic indications for garlic bulb are prophylaxis of atherosclerosis treatment of elevated blood lipid levels, insufficiently influenced by diet improvement of the circulation in peripheral arterial vascular disease and respiratory infections and catarrhal conditions. 

Hypolipaemic substance which reduces blood lipid levels. 

The use of androstenedione (16.3), as a metabolic precursor of testosterone, to increase athletic prowess is unproved and may lead to detrimental effects, such as elevated blood lipid levels, liver problems, and testicular atrophy.35... 

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