L-sulforaphane

In 2005, Haristoy and coworkers investigated the activities of 12 isothiocyanates (ITC) and L-sulforaphane isolated from Cruciferous plant species in 25 strains of HP. Medicinal plants from the Cruciferae are well known to have chemopreventative effects on the GI tract, and are... 

Gross, C.L., Nealley, E.W, Nipwoda, M.T., et al., 2006. Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity. Cutan. Ocul. Toxicol. 25, 155-163. 

CHUNG F L, CONAWAY c c, RAO c V and REDDY B s (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate . Carcinogenesis, 21 2287-91. 

Matusheski NV, Swamp R, Juvik JA, Mithen R, Bennett M, Jeffery EH (2006) Epithiospecifier protein from broccoli Brassica oleracea L. ssp. Italica) inhibits formation of the anticancer agent sulforaphane. J Agric Food Chem 54 2069-2076... 

Agrawal, S., Winnik, B., Buckley, B., Mi, L., Chung, F.-L., and Cook, T. J. (2006). Simultaneous determination of sulforaphane and its major metabolites from biological matrices with liquid chromatography-tandem mass spectroscopy. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 840 99-107. 

Langouet S, Furge LL, Kerriguy N, et al. Inhibition of human cytochrome P450 enzymes by l,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. Chem Res Toxicol 2000 13(4) 245-252. 

Fahey, J.W. and Talalay, R, Antioxidant functions of sulforaphane a potent inducer of phase II detoxication enzymes. Food Chem. Toxicol, 37, 973-979, 1999. Shapiro, T.A., Fahey, J.W., Wade, K.L., Stephenson, K.K., and Talalay, P. Chemo-protective glucosinolates and isothiocyanates of broccoh sprouts metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev., 10, 501-508, 2001. Faulkner, K., Mithen, R., and Williamnson, G., Selective increase of the potential anticarcinogen 4-methylsulphinylbutyl glucosinolate in broccoh. Carcinogenesis, 19, 605-609, 1998. 

Chiao, J.W., Chung, F.L., Kancherla, R., Ahmed, T., Mittelman, A., Conaway, C.C., Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells, Int. J. Oncol, 20, 631-636, 2002. 

Petri N, Tannergren C, Holst B, Mellon FA, Bao Y, Plump GW, Bacon J, O Leary KA, Kroon PA, Knutson L, Forsell P, Eriksson T, Lennernas H, Williamson G. Absorption/metaboUsm of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. 

Prochaska Z. Isolation of sulforaphane from hoary cress (Lepidium draba L). Collet Czech Chem... 

Dornberger K, Bokel V, Heyer J, Schonfeld C, Tonew M, Tonew E. Untersuchungen iiber die isothiocyanate crysolin und sulforaphan aus Cardaria draba L. Pharmazie 1975 30 792-796. 

Conaway CC, Getahun SM, Liebes LL, Pusateri DJ, Topham DKW, Botero-Omary M, Chung F-L. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer 2000 38 168-178. 

Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont M-A, Chevolleau S, Gasc N, Tulliez J, Terce F. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 2000 60 1426-1433. 

Payen L, Courtois A, Loewert M, GuiUouzo A, Fardel O. Reactive oxygen speciesrelated induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochem Biophy Res Commu 2001 282 257-263. 

Comblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MS, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K (2007) Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 28 1485-1490... 

Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH (2005) Induction of the Nrf2-driven antioxidant response corrfers neuroprotection dirring mitochondrial stress in vivo Shinkai Y, Sumi D, Fukami I, Ishii T, Kumagai Y (2006) Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsoiic and its cytotoxicity in primary mouse hepatocytes. FEBS Lett 580 1771-1774... 

Hong, R, Freeman, M. L., Liebler, D. C. (2005). Identification of sensor cysteines in human Keapl modified by the cancer chemopreventive agent sulforaphane. Chem. Res. Toxicol, 18, 1917-1926. 

Singh, A.V., Xiao, D., Lew, K.L., Dhir, R., and Singh, S.V. 2004. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis, 25(1), 83-90. doi 10.1093/carcin/bggl78. 

Briones-Labarca, V Plaza-Morales, M Giovagnoli-Vicuna, C Jamett, F. High hydrostatic pressure and ultrasound extractions of antioxidant compounds, sulforaphane and fatty acids from Chilean papaya (Vasconcellea pubescens) seeds Effects of extraction conditions and methods. L WT - Food Science and Technology, v. 60, p. 525-534. 

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