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Ketoprofen

Therapeutic Function Antiinflammatory Chemical Name m-benzoylhydratropic acid Common Name 2-(3-benzoylphenyl)propionic acid [Pg.862]

Trade Name Manufacturer Country Year Introduced [Pg.863]

In an initial step, the sodium derivative of ethyl (3-benzoylphenyl)cyanoecetate is prepared as follows (3-benzoylphenyl)acetonitrile (170 g) is dissolved in ethyl carbonate (900 g). There is added, over a period of 2 hours, a sodium ethoxide solution [prepared from sodium (17.7 g) and anhydrous ethanol (400 cc)], the reaction mixture being heated at [Pg.863]

ethyl methyl(3-benzoylphenyl)cyanoacetate employed as an intermediate material is prepared as follows The sodium derivative of ethyl (3-benzoylphenyl)cyanoacetate (131 g) is dissolved in anhydrous ethanol (2 liters). Methyl iodide (236 g) is added and the mixture is heated under reflux for 22 hours, and then concentrated to dryness under reduced pressure (10 mm Hg). The residue is taken up in methylene chloride (900 cc) and water (500 cc) and acidified with 4N hydrochloric acid (10 cc). The methylene chloride solution is decanted, washed with water (400 cc) and dried over anhydrous sodium sulfate. The methylene chloride solution is filtered through a column containing alumina (1,500 g). Elution is effected with methylene chloride (6 liters), and the solvent is evaporated under reduced pressure (10 mm Hg) to give ethyl methyl(3-benzoylphenyl)cyano-acetate (48 g) in the form of an oil. [Pg.864]

In the final production preparation, a mixture of ethyl methyl(3-benzoylphenyl)cyano-acetate (48 g), concentrated sulfuric acid (125 cc) and water (125 cc) is heated under reflux under nitrogen for 4 hours, and water (180 cc) is then added. The reaction mixture is extracted with diethyl ether (300 cc) and the ethereal solution is extracted with N sodium hydroxide (300 cc). The alkaline solution is treated with decolorizing charcoal (2 g) and then acidified with concentrated hydrochloric acid (40 cc). An oil separates out, which is extracted with methylene chloride (450 cc), washed with water (100 cc) and dried over anhydrous sodium sulfate. The product is concentrated to dryness under reduced pressure (20 mm Hg) to give a brown oil (33.8 g). [Pg.864]


An hplc assay was developed suitable for the analysis of enantiomers of ketoprofen (KT), a 2-arylpropionic acid nonsteroidal antiinflammatory dmg (NSAID), in plasma and urine (59). Following the addition of racemic fenprofen as internal standard (IS), plasma containing the KT enantiomers and IS was extracted by Hquid-Hquid extraction at an acidic pH. After evaporation of the organic layer, the dmg and IS were reconstituted in the mobile phase and injected onto the hplc column. The enantiomers were separated at ambient temperature on a commercially available 250 x 4.6 mm amylose carbamate-packed chiral column (chiral AD) with hexane—isopropyl alcohol—trifluoroacetic acid (80 19.9 0.1) as the mobile phase pumped at 1.0 mL/min. The enantiomers of KT were quantified by uv detection with the wavelength set at 254 nm. The assay allows direct quantitation of KT enantiomers in clinical studies in human plasma and urine after adrninistration of therapeutic doses. [Pg.245]

AGP columns have wide appHcation for the direct separation of enantiomers of many different classes of dmgs, amines, acids, and nonprotolytic compounds (18,23). Acidic dmgs resolved include ibuprofen [15687-27-17, C 2H g02, ketoprofen [22071 -15 ] and naproxen [22204-53-17,... [Pg.99]

Benzoyl-2,3-dihydro-lH-pyrrolizine-l-cai boxylic acid (ketorolac, L ) and 2-(3-benzoyl-phenyl)propionic acid (ketoprofen, L ) ai e biologically activ ligands used in medicine as non-steroidal anti-inflammatory dmgs. [Pg.394]

Electropherograms of a urine sample (8 ml) spiked with non-steroidal anti-inflammatory drugs (10 p-g/ml each) after direct CE analysis (b) and at-line SPE-CE (c). Peak identification is as follows I, ibuprofen N, naproxen K, ketoprofen P, flurbiprofen. Reprinted from Journal of Chromatography, 6 719, J. R. Veraait et al., At-line solid-phase exti action for capillary electrophoresis application to negatively charged solutes, pp. 199-208, copyright 1998, with permission from Elsevier Science. [Pg.287]

Y. Oda, N. Asakawa, Y. Yoshida and T. Sato, On-line determination and resolution of the enantiomers of ketoprofen in plasma using coupled achiral-cliiral high-performance liquid chromatography , 7. Pharm. Biomed. Anal. 10 81-87 (1992). [Pg.294]

Zactane - Ethoheptazine Zactipar- Ethoheptazine Zactirin - Ethoheptazine Zaditen Ketoprofen Zaditen Ketotifen... [Pg.1756]

Fig. 2-8. Chromatograms of ketoprofen in reversed phase on vaneomyein (A), teieoplanin (B), risto-eetin A (C), vaneomyein + teieoplanin (D), ristoeetin A + teieoplanin (E), and ristoeetin A + vaneomyein + teieoplanin (F). All eolumns were 100 x 4.6 mm. The numbers by the peaks refer to the retention time in minutes. The mobile phase was methanol 0.1 % triethylammonium aeetate (25/75 v/v) pH 6.0. The flow rate was 1.0 mL min at ambient temperature (23 °C). Fig. 2-8. Chromatograms of ketoprofen in reversed phase on vaneomyein (A), teieoplanin (B), risto-eetin A (C), vaneomyein + teieoplanin (D), ristoeetin A + teieoplanin (E), and ristoeetin A + vaneomyein + teieoplanin (F). All eolumns were 100 x 4.6 mm. The numbers by the peaks refer to the retention time in minutes. The mobile phase was methanol 0.1 % triethylammonium aeetate (25/75 v/v) pH 6.0. The flow rate was 1.0 mL min at ambient temperature (23 °C).
A new brush-type CSP, the Whelk-0 1, was used by Blum et al. for the analytical and preparative-scale separations of racemic pharmaceutical compounds, including verapamil and ketoprofen. A comparison of LC and SFC revealed the superiority of SFC in terms of efficiency and speed of method development [50]. The Whelk-0 1 selector and its homologues have also been incorporated into polysiloxanes. The resulting polymers were coated on silica and thermally immobilized. Higher efficiencies were observed when these CSPs were used with sub- and supercritical fluids as eluents, and a greater number of compounds were resolved in SFC compared to LC. Compounds such as flurbiprofen, warfarin, and benzoin were enantioresolved with a modified CO, eluent [37]. [Pg.307]

Other arylpropionic acids include naproxen, ketopro-fen and flurbiprofen. They share most of the properties of ibuprofen. The daily oral dose of ketoprofen is 50-150 mg, 150-200 mg for flurbiprofen and 250-1000 mg for naproxen. Whereas the plasma elimination half-life of ketoprofen and flurbiprofen are similar to that of ibuprofen (1.5-2.5 h and 2.4-4 h, respectively), naproxen is eliminated much more slowly with a half-life of 13-15 h. [Pg.875]


See other pages where Ketoprofen is mentioned: [Pg.543]    [Pg.543]    [Pg.386]    [Pg.389]    [Pg.404]    [Pg.98]    [Pg.98]    [Pg.394]    [Pg.270]    [Pg.240]    [Pg.257]    [Pg.862]    [Pg.863]    [Pg.1616]    [Pg.1632]    [Pg.1671]    [Pg.1671]    [Pg.1675]    [Pg.1681]    [Pg.1691]    [Pg.1699]    [Pg.1700]    [Pg.1705]    [Pg.1708]    [Pg.1709]    [Pg.1710]    [Pg.1711]    [Pg.1711]    [Pg.1712]    [Pg.1716]    [Pg.1723]    [Pg.1726]    [Pg.1733]    [Pg.1736]    [Pg.1738]    [Pg.1738]    [Pg.1741]    [Pg.1755]    [Pg.875]    [Pg.160]   
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