Ketoprofen adverse effects

The drugs like ibuprofen, flurbiprofen, ketoprofen etc. possess antiinflammatory property similar to aspirin but toxicity and adverse effects are fewer and of lesser intensity. These preparations alone and in combination with other NSAIDs are used for treatment of inflammatory disorders. 

The effectiveness of ketoprofen at dosages of 100-300 mg/d is equivalent to that of other NSAIDs. In spite of its dual effect on prostaglandins and leukotrienes, ketoprofen is not superior to other NSAIDs in clinical efficacy. Its major adverse effects are on the gastrointestinal tract and the central nervous system (see common adverse effects above). 

The spectrum of adverse effects of ketoprofen is similar to that of ibuprofen. 

Studies on a modified-release formulation of ketoprofen showed a similar pattern of adverse effects to the usual formulations (SEDA-12, 86). 

The manufacturer states that nefopam should not be given to patients taking non-selective MAOIs and caution should be used in those taking tricyclic antidepressants, antimuscarinics and sym-pathomimetics. The intensity and incidence of adverse effects are somewhat increased when nefopam is given with codeine, pentazocine or dextropropoxyphene (propoxyphene), and the CNS depressant effect of dihydrocodeine may have contributed to a fatal overdose with nefopam. However, a morphine-sparing effect has been reported. Nefopam may also have a synergistic analgesic effect with ketoprofen. 

Ketoprofen reduced morphine-associated respiratory depression, and did not alter morphine pharmacokinetics. Similarly, diclofenac did not alter morphine pharmacokinetics in one study. Improved pain relief and reduced adverse effects have been found when morphine was given with lomoxicam, ketoprofen, or ketorolac. However, in another, diclofenac slightly increased respiratory depression despite reducing morphine use, possibly because of persistent levels of an active metabolite of morphine. Diclofenac did not affect the pharmacokinetics or analgesic effects of codeine in healthy subjects. Intramuscular diclofenac did not affect the pharmacokinetics of methadone solution in cancer patients. Ibuprofen did not appear to interact... 

The anti-inflammatory drugs benzydamine and ketoprofen formed coprecipitates with pectin.A Langmuir-type of binding isotherm was obtained on equilibrium dialysis and this slow dissolution of the precipitate suggested that binding may help to reduce the adverse effects of these drugs to the stomach on oral administration. 

KETOPROFEN Take with antacids, food, or milk to minimize adverse Gl effects. 

Development of a prolonged action dosage form of ketoprofen will bring about several desirable therapeutic advantages improvement of patient compliance minimization of blood level fluctuations reduction of the total amount of drug administered reduction of incidence of both local and systemic adverse side effects [3]. 

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