Ketoprofen Aspirin

WiUiams RL, Upton RA, Btrskin IN, Jones RM. Ketoprofen-aspirin interactions. Clin Pharmacol Ther 1981 30(2) 226-31. 

Acetaminophen, aspirin, ibuprofen, naproxen, ketoprofen, indometha-cin, and ketorolac are effective. 

NSAiDs (nonsteroidai anti-infiammatory drugs) inhibitors of cyclooxygenase, including aspirin, ibuprofen, and ketoprofen, among many others. 

Many NSAIDs inhibit both COX-1 and COX-2. Most NSAIDs are mainly COX-1 selective (eg, aspirin, ketoprofen, indomethacin, piroxicam, sulindac). Others are considered slightly selective for COX-1 (eg, ibuprofen, naproxen, diclofenac) and others may be considered slightly selective for COX-2 (eg, etodolac. 

Impairment of mitochondrial jj-oxidation leads to accumulation of fat, resulting in steatosis. Examples are various tetracycline derivatives, valproic acid (used to treat seizures) and overdoses of aspirin [64—66]. Certain NSAIDs such as ibuprofen, ketoprofen and naproxen also have the ability to inhibit jj-oxidation [67-69]. 

Common NSAIDs include aspirin, ibuprofen, indomethacin, naproxen, and ketoprofen. Even though anti-inflammatories generally target cyclooxygenase, there are apparent differences in the details of how they relieve pain. For example, aspirin acts by primarily inhibiting the COX-dependent synthesis of eicosanoids, which are end products of metabolism of essential fatty acids including prostaglandin... 

The drugs like ibuprofen, flurbiprofen, ketoprofen etc. possess antiinflammatory property similar to aspirin but toxicity and adverse effects are fewer and of lesser intensity. These preparations alone and in combination with other NSAIDs are used for treatment of inflammatory disorders. 

A very large number of copper compounds have been tested for antiinflammatory activity, and various copper complexes of antiarthritic drugs have been found to be more effective than the parent drugs alone (including aspirin, D-penicillamine, ketoprofen and gold thiomalate).25... 

Ketoprofen Orudis, Oruvail, others Similar to aspirin s benefits and side effects but has relatively short half-life (1-2 hours]. 

Aspirin (many trade names) Ketoprofen (Orudis, others)... 

HPLC Grind,ultrasonicate with H20/CH5CN, filter Silica 5 mAf P04, pH 2.6-CH3CN (95 5), 1 ml/min 254 nm Resolved aspirin, fenbufen, ibuprofen, indomethacin, ketoprofen, sulindac, naproxen, tolmetin [178]... 

Enalapril, paracetamol, sotalol, dipyrone, vancomycin, captopril, fluconazole, cefazolin, metoprolol, aspirin, ticlopidine, prednisolone, propranolol, digoxin, sildenafil, furosemide, dexamethasone, carvedilol, ketoprofen, nifedipine, terbinafine, acenocoumarol, spironolactone/urine HPLC DAD Column LiChroCART Purospher STAR, RP-18e (250 x 4 mm, 5 pm) Mobile phase MeOH ACN 0.05 % TFA in water (gradient elution) Detection DAD X = 200 50 nm Adjusted to pH 7.0, protein precipitation LOD 0.01-1.44 pg/mL LOQ 0.04-4.35 pg/mL [72]... 

Concurrent administration of aspirin reduces ketoprofen protein binding and increases its clearance. Salicylate also reduces the metabohc conversion of ketoprofen to its conjugates and their renal elimination, and enhances its conversion to non-conjugated metabohtes (15). 

Miyairi A, Ohori K. Aspirin-mduced asthma due to rubbing ketoprofen ointment. Kokyu 1990 9 110. 

To explore the frequency of continuous use of over-the-counter drugs and the potential for harmful interactions between OTC drugs and prescribed drugs, a population-based interview survey was conducted in 10 477 subjects (231). Daily use of over-the-counter drugs was reported by 7% of the subjects and 4% of those who used over-the-counter drugs had taken combinations with potential for clinically significant interactions. Interactions were most common for NSAIDs such as ketoprofen (15% of keto-profen users), ibuprofen (10%), and aspirin (6%). Unfortunately, this study did not provide information on whether the potential interactions led to actual clinical problems. 

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

The OTC oral NSAIDs, including aspirin, ibuprofen, ketoprofen, and naproxen sodium, are particularly effective in settings in which inflam-... 

The list of compounds presented in Table 6.4 includes copper complexes of well-known antiarthritic drugs, including salicylic acid, aspirin, diflunisal, niflumic acid, D-penicillamine, hydrocortisone, dexamethasone, dimethyl-sul-phoxide, clopirac, ketoprofen, ibuprofen, (+ )-naproxen, indomethacin, me-fenamic acid, thiomalic acid, phenylbutazone, lonazolac, isoxicam and azo-propazone. While there has been much discussion concerning the qualitative and quantitative activities of these complexes [136, 152-156, 164, 187], it is... 

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