Fasted, 123 ketoprofen

Sotalol, metoprolol, propranolol, carvedilol, salicylic acid, dexamethasone, prednisolone, ketoprofen/urine UHPLC UV Column Chromolith Fast Gradient Monolithic RP-18e (50 x 2 mm) Mobile phase Solvent A 0.05 % TEA in water Solvent B ACN (gradient elution) Detection 2 = 227, 240, 254 nm Extraction SPE/column SDB/elution MeOH LOD 11.8-42.2 ng/mL LOQ 35.6-126.7 ng/mL [79]... 

Figure 3 Effect of SPH particle size on the disintegration time of ketoprofen fast-disintegrating tablets.

In Vivo Absorption Studies IVIale Wister albino rats, 270 - 310 g, were fasted for 2k h prior to drug administration. Ketoprofen powder or its physical mixture with methyl-3-CD (molar ratio l l) was freshly suspended in distilled water and administrated- into the stomach of a rat through a sonde at a dose of 25 mg/kg (ketoprofen) in a constant volume of 5 ml/kg. Blood samples were obtained from the femoral artery via a cannula and immediately centrifuged at 3000 rpm to obtain plasma samples. The concentration of ketoprofen in plasma was determined... 

The release kinetics of drugs can be drastically affected by their adsorption onto aerogels. The use of hydrophilic aerogels as carriers results in a very fast release of the drugs [4,6]. For instance, the release of ketoprofen from the ketoprofen-aerogel formulation (in powdered form) was determined experimentally (paddle method according to USP) and compared to that of crystalline ketoprofen (Figure 31.4) [6]. 

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