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Ketone important types

This approach is important for the synthesis of cinnolines. CHEC(1984) <1984CHEC(2)1> already covered several examples. The methodology used starts with an aniline ortho substituted with an alkene (Widman-Stoermer type), alkyne (Richter type), or enolisable ketone (Borsche type) which is diazotisized, delivering the sixth atom, allowing cyclization. CHEC-II(1996) <1996CHEC-II(6)1> gave more examples. [Pg.77]

Hydrochlorination of Alkynes When Thomas and coworkers treated different alkynes in aqueous methanol with HAuC14 and observed the corresponding ketones as major products (Equation 8.28), with less than 5% of methyl vinyl ethers and vinyl chlorides, they were unaware of the fascinating treasure that was in front of them. Some of the most important types of products for gold catalysis were reported in the aforementioned study, but unfortunately at that time this process was believed to be a gold(III) oxidation process, despite the fact that the reaction achieved almost six turnovers. [Pg.446]

Aldehydes and ketones are comparatively reactive materials and can be the cause of many stability problems in perfume compounds. Two of the most important types of reaction that are specific to these materials are the formation of acetals with alcohols, and the so-called... [Pg.224]

Since its introduction early in this century, the deoxygenation of aldehydes and ketones to methyl or methylene derivatives, respectively, via base treatment of hydrazone intermediates (equation 1) has proven to be one of the most convenient and synthetically useful processes available for this important type of transformation. The reaction is termed the Wolff-Kishner reduction in recognition of the two original independent discoverers.However, the initial recipes introduced proved tedious and unreliable with many structural, especially hindered, examples. This led to substantial efforts devoted over the years to developing more convenient and successful experimental procedures, resulting in a number of improved and more reliable modifications which are most often utilized at present. More recently, modified procedures have been provided which utilize hydride reductions of p-toluenesulfonylhydrazone (to-sylhydrazone) derivatives and subsequent decomposition to release the hydrocarbon products under much milder and less basic conditions than those normally required for Wolff-Kishner reductions (equation 2). [Pg.328]

Substitution of an amino for the alkoxyl group of simple aliphatic ethers has little preparative importance the ether linkage must be weakened by a carbonyl, carboxyl, or nitrile group in the -position if the reaction is to occur under not too drastic conditions. Certain /8-methoxy ketones of type (17) can be converted into / -amino ketones below 100°.1081 Cleavage of the ether group in activated enol ethers is still easier for instance, 2-(acetoxymethylene)-... [Pg.532]

An important type of aromatic Claisen rearrangement occurs in the Fischer indole synthesis. " The Fischer indole synthesis involves the condensation of an arylhydrazine with an aldehyde or ketone to give an arylhydrazone, which, in the presence of a catalyst undergoes rearrangement and elimination of ammonia to give the indole ring. One of many different protic or Lewis acid catalysts can be used. For example, Woodward s synthesis of strychnine commenced with the condensation of the ketone 303 and phenylhydrazine in the presence of polyphosphoric acid to give the indole 304 (3.194). [Pg.251]

But what do we do if we want the product of a ketene [4 + 2] cycloaddition We must use a compound that is not a ketene but that can be transformed into a ketone afterwards—a masked ketene or a ketene equivalent. The two most important types are nitroalkenes and compounds such as the cyanohydrin ester in the second example. [Pg.899]

Elimination is one of the most important types of reactions for making carbon-carbon multiple bonds in organic synthesis. However, only a few examples of elimination reactions in microflow reactors have been reported. P-Hydroxyketones provide the corresponding dehydrated products, a,P-unsaturated ketones, in almost quantitative yields under the microfluidic conditions, whereas conventional macro batch reactors give lower yields of the products due to recovery of the starting materials and formation of other hydrophobic byproducts (Figure 5.3) [21]. [Pg.604]

From the perspective of the organic chemist, the addition of carbon nucleophiles is the most important type of nucleophilic addition to a carbonyl group because these reactions form new carbon-carbon bonds. In this section, we describe the preparation and reactions of Grignard reagents and their reaction with aldehydes and ketones. [Pg.423]

Low-valent nitrogen and phosphorus compounds are used to remove hetero atoms from organic compounds. Important examples are the Wolff-Kishner type reduction of ketones to hydrocarbons (R.L. Augustine, 1968 D. Todd, 1948 R.O. Hutchins, 1973B) and Barton s olefin synthesis (p. 35) both using hydrazine derivatives. [Pg.97]

By analogy to the hydration of alkenes hydration of an alkyne is expected to yield an alcohol The kind of alcohol however would be of a special kind one m which the hydroxyl group is a substituent on a carbon-carbon double bond This type of alcohol IS called an enol (the double bond suffix ene plus the alcohol suffix ol) An important property of enols is their rapid isomerization to aldehydes or ketones under the condi tions of their formation... [Pg.379]

Actinide ions form complex ions with a large number of organic substances (12). Their extractabiUty by these substances varies from element to element and depends markedly on oxidation state. A number of important separation procedures are based on this property. Solvents that behave in this way are thbutyl phosphate, diethyl ether [60-29-7J, ketones such as diisopropyl ketone [565-80-5] or methyl isobutyl ketone [108-10-17, and several glycol ether type solvents such as diethyl CeUosolve [629-14-1] (ethylene glycol diethyl ether) or dibutyl Carbitol [112-73-2] (diethylene glycol dibutyl ether). [Pg.220]

A varnish is often appHed on top of the paint layers. A varnish serves two purposes as a protective coating and also for an optical effect that enriches the colors of the painting. A traditional varnish consists of a natural plant resin dissolved or fused in a Hquid for appHcation to the surface (see Resins, natural). There are two types of varnish resins hard ones, the most important of which is copal, and soft ones, notably dammar and mastic. The hard resins are fossil, and to convert these to a fluid state, they are fused in oil at high temperature. The soft resins dissolve in organic solvents, eg, turpentine. The natural resin varnishes discolor over time and also become less soluble, making removal in case of failure more difficult (see Paint and FINNISH removers). Thus the use of more stable synthetic resins, such as certain methacrylates and cycHc ketone resins, has become quite common, especially in conservation practice. [Pg.420]

The important role played by the quinicines (rubatoxanones, quina-toxines) in the syntheses of the dihydrocinchona alkaloids and the possibility that such substances might be used for the preparation of products approaching quinine in therapeutical interest, has led to the production of a large number of quinolyl ketones of various types and the corresponding secondary alcohols, and other derivatives obtainable from them, of which mention may be made of Rubtzov s syntheses of several isomerides of dihydroquinine. ... [Pg.460]

The 7T orbital extends over the entire enone system. As a consequence the C —CO bond is strengthened in the excited states and a-cleavage, the important primary photoprocess in nonconjugated ketones, is not observed. The most important unimolecular reaction types are processes which involve... [Pg.317]

In general however the various possible reaction pathways give rise to formation of a mixture of products. The type I-cleavage reaction is only of limited synthetic importance, but rather an interfering side-reaction—e.g. with an attempted Paterno-Buchi reaction, or when an aldehyde or ketone is used as sensitizer in a [2 -I- l -cy do addition reaction. [Pg.215]

Aldol reactions occur in many biological pathways, but are particularly important in carbohydrate metabolism, where enzymes called aldolases catalyze the addition of a ketone enolate ion to an aldehvde. Aldolases occur in all organisms and are of two types. Type 1 aldolases occur primarily in animals and higher plants type II aldolases occur primarily in fungi and bacteria. Both types catalyze the same kind of reaction, but type 1 aldolases operate place through an enamine, while type II aldolases require a metal ion (usually 7n2+) as Lewis acid and operate through an enolate ion. [Pg.901]

As attractive as the transannular bridging of bis(thiolactones) to bicyclic bis(oxepane) frameworks is, our inability to convert the disulfide bridging product (see 25, Scheme 5) to a mmv-fused bre-vetoxin-type bis(oxepane) (see 28) necessitated the development of a modified, stepwise strategy. This new stepwise approach actually comprises two very effective methods for the construction of cyclic ethers the first of these is the intramolecular photo-induced coupling of dithioesters, and the second is the reductive cyclization of hydroxy ketones. We will first address the important features of both cyclization strategies, and then show how the combination of the two can provide an effective solution to the problem posed by trans-fused bis(oxepanes). [Pg.742]

In this chapter, we have examined the use of cells and enzymes to chemically transform lipids. We have had to be selective and have predominantly focused attention on the transformation of sterols and steroids. We first explained why these compounds were commercially important and why they only occur in low concentrations in natural systems. We pointed out that a very large number of reaction types are possible, but those which have found greatest use include stereospedfic hydroxylations, alcohol/ketone interconversion, hydrolysis, conjugation and isomerisation. [Pg.340]

When applied to ketones, this is called Norrish Type / cleavage or often just Type I cleavage. In a secondary process, the acyl radical R —CO can then lose CO to give R radicals. Another example of a category 1 process is cleavage of CI2 to give two Cl atoms. Other bonds that are easily cleaved by photolysis are the 0—0 bonds of peroxy compounds and the C—N bonds of aliphatic azo compounds R—N=N—R. The latter is an important source of radicals R , since the other product is the very stable N2. [Pg.318]


See other pages where Ketone important types is mentioned: [Pg.92]    [Pg.29]    [Pg.93]    [Pg.77]    [Pg.303]    [Pg.44]    [Pg.1239]    [Pg.185]    [Pg.562]    [Pg.182]    [Pg.402]    [Pg.226]    [Pg.93]    [Pg.2]    [Pg.1120]    [Pg.952]    [Pg.1120]    [Pg.6]    [Pg.66]    [Pg.53]    [Pg.55]    [Pg.81]    [Pg.131]    [Pg.74]    [Pg.243]    [Pg.335]    [Pg.445]    [Pg.105]    [Pg.48]   
See also in sourсe #XX -- [ Pg.127 ]

See also in sourсe #XX -- [ Pg.86 , Pg.485 ]




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Ketone important

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