Keratitis with

The eight most severely injured patients (15%) with Grade IV injuries had gross scarring, vascularization, and a permanent severe reduction in vision, bilateral in one case [22]. There were two cases of infectious keratitis with Staphylococcus aureus in patients with persistent corneal epithelial defects this progressed to globe perforation in one case. One patient underwent... 

Toxic keratitis has also been reported after abuse of cyclopentolate. Instillation of 100 to 400 drops of the 1% solution over several months caused a diffuse epithelial punctate keratitis with marked conjunctival hyperemia. As expected, the pupils were widely dilated and unresponsive to light. 

A small randomized clinical trial demonstrated significantiy faster healing of HSV keratitis with oral valacyclovir than topical acyclovir ointment (Sozen,Avunduk,Akyol). 

The treatment of HSV epithelial keratitis with oral acyclovir has not been studied by the Herpetic Eye Disease Study, but there is some evidence to suggest that oral acyclovir may be as effective as topical acyclovir. The clinical management of HSV in immunocompromised patients differs from that of immimocompetent patients because the immimocompromised experience more frequent and more severe infections. 

Topical fluconazole may be safe and effective in managing Candida keratitis with abscess formation. 

Kosrirukvongs P, Wanachiwanawin D, Visvesvara GS, et al. Treating Acanthamoeba keratitis with chlorhexidine. Ophthalmology 1999 106(4) 798-802. 

Larkin DF, Kilvington S, Dart JK. Treatment of Acanthamoeba keratitis with polyhexamethylene biguanide. Ophthalmology 1992 99(2) 185-191. 

Seal D, Hay J, Kirkness C, et al. Successful medical therapy of Acanthamoeba keratitis with topical chlorhexidine and propamidine. Eye 1996 10(4) 413-421. 

Ohashi Y. Treatment of herpetic keratitis with acyclovir benefits and problems. Ophthalmologica 1997 211(Suppl 1) 29-32. 

In four patients, accidental corneal exposure to Hibiclens (4% chlorhexidine formulated with a detergent) resulted in keratitis, with severe and permanent corneal opacification (19). 

Equine disease caused by T. vivax is usually, but not always, relatively iimocuous. The prepatent period is about 16 days. Parasitemia is cyclic and is accompanied by fever. Between these febrile episodes, urticarial plaques may become evident in the skin and dependent edema develops. In more severe cases, ataxia may develop in the first few days after infection, with muscle tremors occurring around 2 weeks after infection. The ataxia and anorexia are progressive. Keratitis with associated comeal opacity may develop. 

At high concentrations, CN may result in chemical injury to the eye with corneal and conjunctival edema, erosion or ulceration, chemosis, and focal hemorrhages. CN-induced ocular effects on the rabbit eye following exposure to various formulations included lacrimation, chemosis, iritis, blepharitis, and keratitis, with severity dependent on the formulation. 

Vaccinia immune globulin IV is a vaccinia-specific immunoglobulin G (IgG), which directly neutralizes vaccinia virus. It is indicated in treatment and/or modification of aberrant infections induced by vaccinia virus (including accidental implantation in eyes, mouth, or other areas where vaccinia infection would constitute a special hazard), eczema vaccinatum, progressive vaccinia, severe generalized vaccinia, and vaccinia infections in individuals who have skin conditions such as bums, impetigo, varicella-zoster, or poison ivy, or in individuals with eczematous skin lesions. Treat complications that include vaccinia keratitis with caution. 

Misyn, F.A., Besedin, E.V, Obraztsova, A.M., Gostev, VA. (2000c), Experimental Curing of Bacterial Ulcerous Keratitis with Cold Plasma, in Diagnostics and Treatment of Infectious Diseases, Petrozavodsk University,... 

The cases selected met stringent requirements, which included having the characteristic symptoms associated with long-standing idiopathic xerophthalmia, one or both eyes affected with KCS, presence of conjunctivitis with or without keratitis with a Schirmer Tear Test (STT) value of 10 mm/min or less, and having no prior exposure to Cyclosporine A in any form. 

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