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Jurkat T lymphocytes

Cuvilher, O., Rosenthal, D. S., Smulson, M. E., and Spiegel, S., 1998, Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-iibose) polymerase and lamins during Eas- and ceramide-mediated apoptosis in Jurkat T lymphocytes. J. Biol. Chem. 273 2910-2916. [Pg.280]

Park, I. K. and Soderling, T. R., 1995, Activation of Ca2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase in Jurkat T lymphocytes, J Biol Chem, 270, pp 30464-9. [Pg.211]

O Rourke, F. A., LaPlante, J. M. and Feinstein, M. B., 2003, Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. Biochem J 373, 133-43. [Pg.425]

Lampert A, Muller MM, Berchtold S, Lang KS, Palmada M, Dobrovinskaya O, Lang F (2003) Effect of dexamethasone on voltage-gated K+ channels in Jurkat T-lymphocytes. Pflugers Arch 447 168-174... [Pg.85]

Figure 13 In vitro validation of the specific interaction with integrins expressed by Jurkat T lymphocytes of Gd-DTPA-mimRGD. MR images of Jurkat cells stimulated with phorbol 12-myristate 13-acetate (PMA to stimulate integrin expression) (la and 2a) or not (lb and 2b) and incubated with 0.4 mM of Gd-DTPA-mimRGD (la and lb) or with Gd-DTPA (2a and 2b). The test samples are compared with reference samples cells in gelatin (c) and 0.025 mM Gd-DTPA in gelatin (d). (Reprinted with permission Ref 26. Oxford University Press, 2008.)... Figure 13 In vitro validation of the specific interaction with integrins expressed by Jurkat T lymphocytes of Gd-DTPA-mimRGD. MR images of Jurkat cells stimulated with phorbol 12-myristate 13-acetate (PMA to stimulate integrin expression) (la and 2a) or not (lb and 2b) and incubated with 0.4 mM of Gd-DTPA-mimRGD (la and lb) or with Gd-DTPA (2a and 2b). The test samples are compared with reference samples cells in gelatin (c) and 0.025 mM Gd-DTPA in gelatin (d). (Reprinted with permission Ref 26. Oxford University Press, 2008.)...
Previous studies have reported that ERKs are characteristically associated with cell proliferation and protection from apoptosis (Bl, XI), while activation of JNK and p38 MAPK can promote apoptosis in many systems, including B lymphocytes (G5), cerebellar granule cells (K3), hematopoietic cells (K8), and neuronal cells (M3, XI). On the other hand, a recent report found that a pyridinyl imidazole, SB 202190, the specific inhibitor of p38 MAPK, by itself was sufficient to induce apoptosis in T lymphocyte Jurkat cells (N2). Moreover, Th-2-derived cytokine IL-5, the ERK activator and antiapoptotic factor for eosinophils, could also activate p38 MAPK in human eosinophils (BIO). We recently reported that cytokine IL-3, IL-5, and GM-CSF could prolong survival of human eosinophilic leukemic (EoL-1) cells through the transient activation of ERK (W15). On the other hand, activation of p38 MAPK in EoL-1 cells by the NSAID sodium salicylate (NaSal) could lead to apoptosis (W15). We also found that the suppression of ERK using ERK antisense phosphorothioate oligodeoxynucleotides could promote the apoptosis of peripheral blood eosinophils (W16). Moreover, we found that dexamethasone-induced apoptosis and activation of JNK and p38 MAPK activity in eosinophils are regulated by caspases (Z2). [Pg.78]

Han, S., Espinoza, L.A., Liao, H., Boulares, A.H., Smulson, M.E. (2004). Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analogue 2-chloroethylethyl sulphide (GEES) in Jurkat T cells and normal human lymphocytes. Br. J. Pharmacol. 141 795-802. [Pg.915]

Lactotransferrin receptors. The existence of a lactotransferrin receptor was first demonstrated by Van Snick and Masson in 1976 [191] at the surface of mouse peritoneal macrophages and lymphocytes. Since this discovery, the presence of lactotransferrin receptors has been demonstrated at the surface of various cells (for reviews, see refs. [156,158,192,193]) rabbit [48], mouse [165,166], monkey [167] and human [168] enterocytes human HT29 and Caco-2 enterocyte cell lines [194] human monocytes (reviewed in ref. [195]), human alveolar macrophages [196], human neutrophils [195,197], human resting lymphocytes [197], human activated lymphocytes [189], human Jurkat T cell line [190], human epithelial mammary cell line [198], human platelets [199,200] and megakaryocytes [201], hepatocytes [202,203] and in bacteria (for a review see refs. [204,205]). [Pg.218]

At the Center for Biophotonics, we have applied Raman spectroscopy towards the detection and discrimination of individual neoplastic hematopoietic cells to identify characteristic biomarkers for leukemia. We have probed normal human lymphocytes and transformed Jurkat T and Raji B lymphocyte cell lines as model cells of leukemia. Figure 5 shows averaged Raman spectra of 45 healthy normal T cells, 86 transformed Jurkat T cells, 36 healthy normal B cells, and 16 transformed Raji B cells. The Raman spectra of all four cell types exhibit a number of distinct peaks that can be assigned to molecular bonds associated with DNA, protein, lipids, and other cellular constituents. Table 1 lists the Raman peak locations and their assignments. [Pg.154]

Tozeren, P. K.-L. Sung, L. A. Sung, M. L. Dustin, P. Y. Chan, T. A. Springer, and S. Chien, Micromanipulation of adhesion of a jurkat cell to a planar bilayer-membrane containing lymphocyte function-associated antigen 3 molecules, J. Cell. Biol. 116, 997-1066 (1992). [Pg.114]

Purification and Biochemical Properties of IL-2. Early approaches to the purification of IL-2 involved classical preparative and chromatographic methods coupled with a search for T cell lines which did not produce other factors (such as colony stimulating factor, B cell growth factors, lymphocyte activating factor). IL-2 from the cloned human leukemia T-cell line JURKAT has been used for purification and... [Pg.193]

Vero monkey kidney (Veto) cells, human T-cell lymphoma Jurkat cells, Molt-4 cells, and freshly cultured human lymphocytes (Begde et al., 2011 Kindrachuk et al., 2013 Murinda et al., 2003). [Pg.339]


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See also in sourсe #XX -- [ Pg.5 , Pg.78 ]




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