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Irritant bakers

Fructose-1,6-bisphosphatase deficiency, first describ ed by Baker and Winegrad in 1970, has now been reported in approximately 30 cases. It is more common in women and is inherited as an autosomal recessive disorder. Initial manifestations are not strikingly dissimilar from those of glucose-6-phosphatase deficiency. Neonatal hypoglycemia is a common presenting feature, associated with profound metabolic acidosis, irritability or coma, apneic spells, dyspnea, tachycardia, hypotonia and moderate hepatomegaly. Lactate, alanine, uric acid and ketone bodies are elevated in the blood and urine [11]. The enzyme is deficient in liver, kidney, jejunum and leukocytes. Muscle fructose-1,6-bisphosphatase activity is normal. [Pg.704]

Baker, W., et al., Repeated dose skin irritation study on jet fuels—An histopathology study. Air Force Research Laboratory, Technical Report AFRL-HE-WP-TR-1999-0022, 1999. [Pg.235]

Hepatic Effects. An increase in serum iron, which may reflect an adverse liver effect, was observed in workers exposed for 6 months to phenol in a wood treatment liquid (Baj et al. 1994). Elevated concentrations of hepatic enzymes in serum, and an enlarged and tender liver suggestive of liver injury, were reported in an individual who had been exposed repeatedly to phenol vapor for 13.5 years (Merliss 1972). Since phenol was also spilled on his clothes resulting in skin irritation, dermal and inhalation exposures were involved. A 2-fold increase in serum bilirubin was observed in a man who was accidentally splashed with a phenol solution over his face, chest wall, hand, and both arms (Horch et al. 1994). Changes in liver enzymes were not observed in persons exposed to phenol in drinking water for several weeks after an accidental spill (Baker et al. 1978). This study is not conclusive because the measurements were completed 7 months after the exposure. [Pg.120]

While nicotine is the primary active pharmacological agent, tobacco has been shown to be a particularly effective vehicle for delivery of nicotine (US Food and Drug Administration 1995 Hurt and Robertson 1998 Slade et al. 1995 World Health Organization 2001). In fact, published research has determined that tobacco-delivered nicotine is not only more toxic, but more addictive than nicotine in a pure form (e.g., nicotine replacement therapy) (Henningfleld et al. 2000 Royal College of Physicians 2000). As noted by a BW scientist in 1990 Nicotine alone in smoke is not practical, nor are extreme tar/nicotine ratios, since nicotine is too irritating -other substances are required for sensoric reasons (Baker 1990). [Pg.462]

Fletcher, S.T. and Baker, V.A. Use of proteomic technologies for discovery of new markers for skin irritation in vitro. Toxicological Sciences 2003 72(S-1) 13. [Pg.513]

Technical grade triphenylphosphine as obtained from BASF or Aldrich Chemical Company, Inc., is satisfactory. Dichloromethane is obtained from E. Merck or Fluka Chemical Corp. and dried according to commonly used procedures. Pyridine is obtained from Aldrich Chemical Company, Inc., or J. T. Baker ("Baker" grade) and dried by distillation over calcium hydride. Bromine was obtained from Aldrich Chemical Company, Inc., and used as supplied. CAUTION Bromine is a severe irritant, causes burns, and is very poisonous. [Pg.74]

Hamouda T, Myc A, Donovan B, Shih AY, Reuter JD, Baker JR (2001) A novel surfactant nanoemulsion with a unique non-irritant topical antimicrobial activity against bacteria, enveloped viruses and fungi. Microbiol. Res. 156 1—7. [Pg.88]

Hexachlorophene, a phenolic derivative, is a rare sensitizer. Fregert and Hjorth (1969) reported a sensitization index of 0.3% in 660 patients, while acute primary irritant contact dermatitis occurred more frequently (Baker et al. 1969), especially in susceptible skin such as on the scrotum. Positive patch tests believed to be crossreactions to hexachlorophene were found in patients with allergy to tetra-chlorosalicylanilide (Wilkinson 1962 Jillson and Baughman 1963), bithionol, and dichlorophene (Epstein 1966). [Pg.338]

Baker H, Ive FA, Lloyd MJ (1969) Primary irritant dermatitis of the scrotum due to hexa-chlorophene. Arch Dermatol 99 663-693... [Pg.366]

In their study of 2562 persons with work-related dermatoses, Tacke et al. (1995) found irritant contact dermatitis in 70% of 107 bakers, making this dermatitis twice as common as allergic contact dermatitis. Eight of 31 confectioners (26%) had irritant contact dermatitis, compared with 16% with allergic contact dermatitis (Halkier-Sorensen 1996). Of 34 bakers with occupational dermatoses, 12 had irritant contact dermatitis (Heine and Fox 1980) and, in another study, 3 of 10 bakers with occupational dermatoses were diagnosed with irritant contact dermatitis (Nethercott and Holness 1989). [Pg.819]

The nature of the irritants to be found in bakeries is not well defined in the literature. Most bakeries in Europe are small enterprises, and all employees participate in the necessary, frequent cleaning of equipment and of the bakery itself. There is intense exposure to dust from grains, sugar and spices, and extensive contact with moist items such as dough. Fisher (1982) has provided a list of irritants that may be encountered by bakers. Specialised areas, such as sugar artistry, may involve a risk of physical irritancy, particularly thermal injury (Tacke et al. 1995). [Pg.819]

Nothing has been reported regarding specific irritants and allergens in this profession, where the main insult seems to be the thermal exposure. Since sugar artistry is only rarely performed as an isolated profession, mostly in combination with the profession of a baker, cook or confectioner, the irritants and allergens of these occupations should be considered. [Pg.1102]

Apparently it is mildly irritating to flying moths, as Baker and Linn (1984) report that oriental fruit moths will fly in apparently normal fashion upwind in the plume of pheromone and titanium tetrachloride smoke until they reach a critical point near the source and drop to the ground, apparently dead. ... [Pg.223]

Toxicology LD50 (oral, male rat) 1.30 ml 50%/kg, (skin, rabbit, 24 h) 2.54 ml 50%/ kg may cause mod. to severe eye irritation Environmental Readily biodeg. LC50 (rainbow trout, 96 h) 12 mg/l, (sheepshead minnow, 96 h) 32 mg/l, (bobwhite quail) > 5000 mg/l Aramide COM4 [Baker Petrolite]... [Pg.119]

Hazardous decomp, prods. CO, NO, SO thermal decomp, or combustion may generate irritating and highly toxic gases Storage Store in cool, dry, and well-ventilated area WCW-4506 [Baker Petrolite]... [Pg.1938]


See other pages where Irritant bakers is mentioned: [Pg.98]    [Pg.98]    [Pg.42]    [Pg.83]    [Pg.118]    [Pg.870]    [Pg.192]    [Pg.337]    [Pg.372]    [Pg.687]    [Pg.122]    [Pg.337]    [Pg.1183]    [Pg.1240]    [Pg.377]    [Pg.469]    [Pg.1675]    [Pg.1774]    [Pg.2802]    [Pg.3569]    [Pg.3982]    [Pg.4122]    [Pg.4418]    [Pg.4457]    [Pg.4476]    [Pg.11]    [Pg.501]    [Pg.747]    [Pg.864]    [Pg.2132]   
See also in sourсe #XX -- [ Pg.819 ]




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