Iodine administration

SCHONE F, LEITERER M, JAHREIS G and RUDOLPH B (1997) Effect of rapeseed feedstuffs with different glncosinolate content and iodine administration on gestating and lactating sow , Zentralbl Veterinarmed A, 44 325-39. 

Antithyroid drugs are used as primary therapy for Graves disease or as preparative therapy before surgery or radioactive iodine administration. The decision to use antithyroid drugs as... 

Jacobson JM, Hankins GV, Murray JM, Young RL. Selflimited hyperthyroidism following intravaginal iodine administration. Am J Obstet Gynecol 1981 140(4) 472-3. 

Minelli R, Braverman LE, Giuberti T, Schianchi C, Gardini E, Salvi M, Fiaccadori F, Ugolotti G, Roti E. Effects of excess iodine administration on thyroid function in euthyroid patients with a previous episode of thyroid dysfunction induced by interferon-alpha treatment. Clin Endocrinol (Oxf) 1997 47(3) 357-61. 

This condition presents as a consequence of iodide or iodine administration. Its symptoms resemble a low-level upper respiratory infection—burning of the mouth and throat, swollen sub-maxillary glands, and painful teeth and gums. A metallic taste may also be present, caused by the metallic nature of iodine. 

In sows given rapeseed, it has been shown that the low iodine transfer via sows milk to piglets caused by rapeseed inhibition of iodide transport into the milk leads to hypothyroidism and developmental defects in the piglets, and that this is preventable by iodine administration (Schone et al.. 

A low or even a moderate single dose of iodide causes no or only a minor, reduction of hormone production in a normal thyroid. An excessive single dose of iodide leads, via inhibition of the thyroid peroxidase (TPO) mediated iodination (the Wolff-ChaikofF effect), to a transient decrease of intrathyroidal hormone concentration. This was first demonstrated by Wolff and Chaikoff (1949). When high plasma levels of iodide are sustained by repeated iodine administration, the inhibiting effect disappears and normal organic iodine levels in the thyroid are restored, with a decrease in thyroid sodium symporter, as demonstrated by Eng et al. (1999). This effect was demonstrated by Haydl and Waldhausl (1975) in the course of health resort treatments administering iodine-containing mineral waters. 

Strong Iodine Solution USP) or as saturated potassium iodide solution, is administered for approximately 2 weeks to ensure decreased vascularity and firming of the gland, lodism, a side effect of iodine administration, is apparently an allergic reaction characterized by dermatological and common cold-like symptoms (67). 

Stable iodine administration Inhalation of radioiodine in the plume. 

Urgent Protective Actions. Urgent protective actions include sheltering, evacuation, and, where radioactive iodine may be released, stable iodine administration. They also include immediate bans on potentially contaminated food and water. 

Contrast Injection parameters that determine attenuation within the tissue of interest are duration of injection and iodine administration rate or iodine flux. The... 

Arterial enhancement depends on iodine administration rate (or iodine flux) and can be controlled by the injection flow rate (ml/s) and/or the iodine concentration of the contrast medium (mgl/ml) (Fleischmann et al. 2000) (Fig. 8.3). Most of the angiography protocols used on 64-detector-row scanners today utilize very... 

IX FEASIBILITY OF IN VIVO XRF DYNAMIC STUDY OF THE THYROID FOLLOWING STABLE IODINE ADMINISTRATION... 

This result compares well with the drastic drop in thyroid uptake at 100 mg iodine level, as demonstrated by radioiodine uptake studies following stable iodine administration, as performed by Sternthal et al. (6). 

It was of interest to know if iodine administration could facilitate the restoration of thyroid iodine stores. Iodide solution (KI 500 pg/day) was administered during 2 to 7 months in 2 control patients... 

My question to Dr. Nagataki concerns how relatively low but still pharmacological doses of iodine affect thyroidal function and produce transient hypothyroidism. Most of the studies referred to in his lecture were carried out after 2-4 weeks of high iodine administration. What would happen after chronic administration for one or two years ... 

Iodine administration to patients with underlying thyroid disease, more common in areas of marginal iodine intake... 

Iodine administration to patients with no recognized underlying thyroid disease, especially in areas of mild to moderate iodine deficiency. 

Yes, I think that it is true. We did not estimate the intrathyroidal iodine pool, but there have been several reports indicating that it was reduced before iodine administration in such patients. 

In conclusion, the study indicates that the three types of therapy for endemic goitre are equally effective, provided the patients receive a sufficient quantity of iodine. The form of iodine administration, whether as iodide or as L-Thyroxine, is not important except for compliance, which is best when the patient takes only one tablet per day. 

In conclusion, in goitrous NOD mice, iodine administration induces an early afflux of macrophages and dendritic cells followed by infiltration of T helper and T cytotoxic/suppressor lymphocytes. The first step is obtained in various mice strains and is important to initiate the autoimmune reaction. The second step, characteristic of NOD mice, could be equivalent to human thyroiditis. 

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