Microvessel density

Murphy C, McGurk M, Pettigrew J, et al. Nonapical and cytoplasmic expression of interleukin-8, CXCR1, CXCR2 correlates with cell proliferation and microvessel density in prostate cancer. Clin Cancer Res 2005 11 4117-4127. 

B. Uzzan, P. Nicolas, M. Cucherat, G.Y. Perret, Microvessel density as a prognostic factor in women with breast cancer A systematic review of the literature and metaanalysis, Cancer Res. 64 (2004) 2941-2955. 

Fox, S. B., Leek, R. D., Weekes, M. P., Whitehouse, R. M., Gatter, K. C., and Harris, A. L. 1995. Quantitation and prognostic value of breast cancer angiogenesis Comparison of microvessel density, chalkley count and computer image analysis. J. Pathol. 777 275-283. 

Hansen, S., Grabau, D. A., Rose, C., Bak, M., and Sorensen, F. B. 1998. Angiogenesis in breast cancer A comparative study of the observer variability of methods for determining microvessel density. Lab. Invest. 75 1563-1573. 

Callagy, G., Dimitriadis, E., Harmey, J., Bouchier-Hayes, D., Leader, M., and Kay, E. 2000. Immunohistochemical measurement of tumor vascular endothelial growth factor in breast cancer. A more reliable predictor of tumor stage than microvessel density or serum vascular endothelial growth factor. Appl. Immunohistochem. Mol. Morphol. 8, 104-109. 

Strohmeyer, D., Strauss, F., Rossing, C., Roberts, C., Kaufmann, O., Bartsch, G., andEffert, P. 2004. Expression of bFGF, VEGF and c-met and their correlation with microvessel density and progression in prostate carcinoma. Anticancer Res. 24, 1797-1804. 

Meert A, Paesmans M, Martin B, Delmotte P, Berghmans T, Verdebout J-M, et al. The role of microvessel density on the survival of patients with lung cancer A systematic review of the literature with meta-analysis. Br J Cancer 2002 87 694-701. 

Buckley, D.L., Drew, P.J., Mussurakis, S., etal. (1997) Microvessel density of invasive breast cancer assessed by dynamic Gd-DTPA enhanced MRI. Journal of Magnetic Resonance Imaging, 1, 461-464. 

Narvekar, N., Critchley, H.O., Cheng, L. and Baird, D.T. (2006) Mifepristone-induced amenorrhoea is associated with an increase in microvessel density and glucocorticoid receptor and a decrease in stromal vascular endothelial growth factor. Human Reproduction, 21, 2312-2318. 

The mean number of microscopic blood vessels in tissue is higher in prostate cancer and prostatic intraepithelial neoplasia (PIN) than normal prostate tissue. In a study evaluating microvessel density (MVD) on needle biopsy the authors found MVD, when combined with Gleason score and preoperative PSA, provided improved ability to predict extraprostatic extension at radical prostatectomy. " Although microvessel density was significant in the multivariate analysis, Gleason score and serum PSA were much more powerful predictors of extraprostatic... 

Bostwick DC, Wheeler TM, Blute M, et al. Optimized microvessel density analysis improves prediction of cancer stage from prostate needle biopsies. Urology. 1996 48 47. 

Gettman MT, Bergstralh EJ, Blute M, et al. Prediction of patient outcome in pathologic stage T2 adenocarcinoma of the prostate lack of significance for microvessel density analysis. Urology. 1998 51 79. 

Gettman MT, Pacelli A, Slezak J, et al. Role of microvessel density in predicting recurrence in pathologic Stage T3 prostatic adenocarcinoma. Urology. 1999 54 479. 

Krupski T, Petroni GR, Frierson Jr HF, Theodorescu JU. Microvessel density, p53, retinoblastoma, and chromogranin A immunohistochemistry as predictors of disease-specific strrvival following radical prostatectomy for carcinoma of the prostate. Urology. 2000 55 743. 

Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors correlations with prognostic parameters. J Exp Clin Cancer Res 25 365. 

Bostwick, D.G. and K.A. Iczkowski. Microvessel density in prostate cancer prognostic and therapeutic utility. Semin Urol Oncol 16 118-23, 1998. 

Tsutsui S, Kume M, Era S. Prognostic value of microvessel density in invasive ductal carcinoma of the breast. Breast Cancer 2003 10 312 319. 

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