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Interval estimate concentration calculations

If VD is significantly altered or a specific concentration is desired, estimation of a dosage regimen becomes more complex. The dosing interval (Tf) is calculated as ... [Pg.891]

From the total amount of the candidate compound and metabolites in the perfusate (100 ml) at the end of the perfusion experiment (after 2 hours) in relation to the total added amount of compound at time 0, the total uptake into the liver can be calculated. In addition the total hepatobiliary elimination of the candidate compound (sum of all collecting intervals (concentration x secreted volume per collecting interval)) can be calculated. From these values together with the remaining tissue concentration a balance calculation can be set up and the proportion of compound metabolism can be estimated. Representative data are shown for a candidate compound with a high first pass effect in Figure 3. [Pg.489]

PK data The PK parameters of ABC4321 in plasma were determined by individual PK analyses. The individual and mean concentrations of ABC4321 in plasma were tabulated and plotted. PK variables were listed and summarized by treatment with descriptive statistics. An analysis of variance (ANOVA) including sequence, subject nested within sequence, period, and treatment effects, was performed on the ln-transformed parameters (except tmax). The mean square error was used to construct the 90% confidence interval for treatment ratios. The point estimates were calculated as a ratio of the antilog of the least square means. Pairwise comparisons to treatment A were made. Whole blood concentrations of XYZ1234 were not used to perform PK analyses. [Pg.712]

As already discussed, reactions at extended electrodes and particles differ only insofar as, at particles, both an oxidation and a reduction process always occur simultaneously. There is, however, one further aspect which may be of importance for using big or small particles. Taking two solutions containing semiconductor particles of different sizes, i.e. for instance of 3 nm and 4 /im, then many more particles are present in the solution containing the 3 nm-particles than in that of 4 /im-particles, provided that the concentration of the semiconductor material is identical in both solutions. As it can easily be calculated, a time interval of 5.4 ms exists between the absorption of two photons in one individual 3 nm-particle for a photon-flux of 4 x 10 cm s assuming that all photons are absorbed in the colloidal solution [114]. In the case of the 4 pm-particles, the time interval is about 20 ps for the same photon flux, i.e. it is shorter by a factor of 10 , compared to the time interval estimated for the 3 nm-particles. This can be important for reactions where two or more electrons are involved, typical in many oxidation- and reduction reactions with organic molecules [114]. [Pg.167]

Neither. These tell you about the linear relation between y and x, true, but in analytical chemistry you are rarely testing the linear model. The standard error of the regression (Sy/X) is a useful number to quote, or calculate 95% confidence intervals on parameters and estimated concentrations of test solutions. Plot residuals against concentration if you are concerned about curvature or heteroscedacity. (Sections 5.3.2, 5.5)... [Pg.17]

From sx the 95% confidence interval on the estimate may be determined by multiplication by the appropriate /-value (/o.o5",n-2)-Standard addition is used when there are potential interferents that would lead to a systematic error that is proportional to concentration. Calculation of the concentration by the standard addition method causes these errors in the measurements to cancel. It is also useful if the analyte cannot be extracted from its matrix, and there is not a matrix matched calibrant available. This may be the case in environmental analysis. Note, however, that standard addition does not compensate for a constant additive interferent. [Pg.157]

With Eq. (2-42) the first-order rate constant can be calculated from concentrations at any two times. Of course, usually concentrations are measured at many times during the course of a reaction, and then one has choices in the way the estimates will be calculated. One possibility is to let r, be zero time for all calculations in this case the same value c° is employed in each calculation, so error in this quantity is transmitted to each rate constant estimate. Another possibility is to apply Eq. (2-42) to successive time intervals. If, as often happens, the time intervals are all... [Pg.31]

Comparisons between observed data and model predictions must be made on a consistent basis, i.e., apples with apples and oranges with oranges. Since models provide a continuous timeseries, any type of statistic can be produced such as daily maximums, minimums, averages, medians, etc. However, observed data are usually collected on infrequent intervals so only certain statistics can be reliably estimated. Validation of aquatic chemical fate and transport models is often performed by comparing both simulated and observed concentration values and total chemical loadings obtained from multiplying the flow and the concentration values. Whereas the model supplies flow and concentration values in each time step, the calculated observed loads are usually based on values interpolated between actual flow and sample measurements. The frequency of sample collection will affect the validity of the resulting calculated load. Thus, the model user needs to be aware of how observed chemical loads are calculated in order to assess the veracity of the values. [Pg.163]

The same kind of optimization has been performed for the thoron daughters. In the calculations the sampling period was set at 30 min and the first decay time interval is started after the decay of the radon daughters (270 min). For a total measurement time of 16 hours the optimized MMC of Pb-212 and Bi-212 are respectively 0.02 Bq/m and 60 Bq/m (270-370 min, 540-960 min). Better results for Bi-212 are obtained with only one decay time interval and an estimation of the ratio of Pb-212 to Bi-212 out of the removal processes (ventilation and deposition of the attached thoron daughters). The influence of the removal rate on the potential alpha energy concentration is small. For the decay interval (270-960 min) the MMC of Pb-212 is 0.014 Bq/m, assuming the sum of the removal rates to be 0.6+0.5/h. [Pg.306]

Sampling rate extrapolation into the low log Ko range is more difficult, because of the increasing resistance of the membrane, which causes the sampling rates to fall below the values that are predicted by Eq. 3.51. Fortunately, this extrapolation is less critical, because compounds that are less hydrophobic than the PRCs typically have attained a substantial degree of equilibrium. As a result, aqueous concentration estimates for these compounds are quite insensitive to uncertainties in the sampling rates. Alternatively, when the log Kow interval between successive PRCs is small, the degree of equilibrium attained by analytes with intermediate log Ko values may be obtained by interpolation. The aqueous concentrations may be subsequently calculated from the partition coefficients and corrected for partial equilibrium attainment. [Pg.69]

We will describe an accurate statistical method that includes a full assessment of error in the overall calibration process, that is, (I) the confidence interval around the graph, (2) an error band around unknown responses, and finally (3) the estimated amount intervals. To properly use the method, data will be adjusted by using general data transformations to achieve constant variance and linearity. It utilizes a six-step process to calculate amounts or concentration values of unknown samples and their estimated intervals from chromatographic response values using calibration graphs that are constructed by regression. [Pg.135]

Figures 57 and 58 shows the estimation results for the intervals of the unmeasured states Cti and Z. Notice how the interval bounds estimated by the interval observer envelop correctly these unmeasured states. For all the other unmeasured states, notice that although the interval observer design did not allow us to tune the convergence rate, the interval observer showed excellent robustness and stability properties and provided satisfactory estimation results in the event of highly corrupted measurements and operational failures. Notice in particular, the robustness of the interval observer around day 25 when the inlet concentrations drastically increased and when a major disturbance occurred at day 31, due to an operational failure, resulting in a rapid fall of both, the dilution rate (which actually fell to zero) and the substrate concentration readings. Off-line readings of Cti and Z (not used in the state estimation calculations) were also added to validate the proposed interval observer design (see Figures 57 and 58). It should be noticed that the compromise between the convergence rate and robustness was not fully achieved until the estimation error dynamics reached the steady state. Figures 57 and 58 shows the estimation results for the intervals of the unmeasured states Cti and Z. Notice how the interval bounds estimated by the interval observer envelop correctly these unmeasured states. For all the other unmeasured states, notice that although the interval observer design did not allow us to tune the convergence rate, the interval observer showed excellent robustness and stability properties and provided satisfactory estimation results in the event of highly corrupted measurements and operational failures. Notice in particular, the robustness of the interval observer around day 25 when the inlet concentrations drastically increased and when a major disturbance occurred at day 31, due to an operational failure, resulting in a rapid fall of both, the dilution rate (which actually fell to zero) and the substrate concentration readings. Off-line readings of Cti and Z (not used in the state estimation calculations) were also added to validate the proposed interval observer design (see Figures 57 and 58). It should be noticed that the compromise between the convergence rate and robustness was not fully achieved until the estimation error dynamics reached the steady state.
The process of providing an answer to a particular analytical problem is presented in Figure 2. The analytical system—which is a defined method protocol, applicable to a specified type of test material and to a defined concentration rate of the analyte —must be fit for a particular analytical purpose [4]. This analytical purpose reflects the achievement of analytical results with an acceptable standard of accuracy. Without a statement of uncertainty, a result cannot be interpreted and, as such, has no value [8]. A result must be expressed with its expanded uncertainty, which in general represents a 95% confidence interval around the result. The probability that the mean measurement value is included in the expanded uncertainty is 95%, provided that it is an unbiased value which is made traceable to an internationally recognized reference or standard. In this way, the establishment of trace-ability and the calculation of MU are linked to each other. Before MU is estimated, it must be demonstrated that the result is traceable to a reference or standard which is assumed to represent the truth [9,10]. [Pg.746]

Isopiestic determination is one of the most commonly used methods for measuring food aw. In this method a sample of known mass is stored in a closed chamber and allowed to reach equilibrium with an atmosphere of known ERH (or equilibrate with a standard of known aw). In the first protocol (see Basic Protocol), a standard salt solution, for which aw is well established, is used to control this atmosphere. The aw of the sample is then determined by equilibration with the resulting atmosphere. In the second protocol (see Alternate Protocol), the isopiestic determination of aw is accomplished by equilibration of the sample with a reference material, for which the relationship between water content and aw is known. The condition of equilibrium is determined by reweighing the sample at intervals until constant mass is reached. The moisture content of the sample is then determined either directly or by calculation from the reference material s original moisture content and change in mass. Unsaturated salt solutions of known ERH can also be used to equilibrate the samples however, this requires estimation of the ERH of the jars at the end of the equilibration by measuring the exact concentration of the salt solution, which may be tedious. [Pg.51]

Because historical data for the soil is not available, to estimate the number of samples for the stockpile characterization, we collect four preliminary samples and analyze them for lead. The concentrations are 120, 60, 200, and 180 mg/kg, with the average concentration of 140 mg/kg and the standard deviation of 63 mg/kg. We use Equation 11, Appendix 1, for the calculation of the estimated number of samples. Using a one-tailed confidence interval and a probability of 0.05, we determine the Student s t value of 2.353 for 3 degrees of freedom (the number of collected samples less one) from Table 1, Appendix 1. [Pg.36]

Fig. 13.3 Plot of the observed relative area versus the concentration of analyte in the standard solution, the estimated calibration line with its 95% confidence interval, and a possible way of calculating the limit of detection... Fig. 13.3 Plot of the observed relative area versus the concentration of analyte in the standard solution, the estimated calibration line with its 95% confidence interval, and a possible way of calculating the limit of detection...
The purpose of this section is to show the calculation of the confidence interval for the variance in an actual example. The statistical data used for this example are given in Table 5.3. In this table, the statistically measured real input concentrations and the associated output reactant transformation degrees are given for five proposed concentrations of the limiting reactant in the reactor feed. Table 5.3 also contains the values of the computed variances for each statistical selection. The confidence interval for each mean value from Table 5.3 has to be calculated according to the procedure established in steps 6-10 from the algorithm shown in Section 5.2.2.1. In this example, the number of measurements for each experiment is small, thus the estimation of the mean value is difficult. Therefore, we... [Pg.346]


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See also in sourсe #XX -- [ Pg.142 ]




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