Interface fluidic

The integration of sensing and other functions in a micro-flow system requires either monolithic, on-chip or hybrid, multi-scale approaches. Concerning the latter, Hessel and Lowe discuss the lack of compatibility of today s fluidic interfaces and report on a German project team developing a standard for micro-reactor interconnection [9, 10]. 

Zhang, D. F., and Zumbrunnen, D. A., Influences of fluidic interfaces on the formation of fine scale structures by chaotic mixing. J. Fluids Eng. 118,40-47 (1996b). 

Wang C., Oleschuk R., Ouchen F., Li J., Thibault R, and Harrison D.J. (2000), Integration of immobilized trypsin bead beds for protein digestion within a micro-fluidic chip incorporating capillary electrophoresis separations and an electrospray mass spectrometry interface, Rapid Commun. Mass Spectrom. 14(15), 1377-1383. 

The use of capillary separations, an NMR probe that contains multiple coils, and the associated capillary fluidics to deliver the samples to and from the coils is the next step in probe development. A future exciting development will be the interfacing of such intelligent NMR probe and fluidic systems with other integrated detection modalities such as fluorescence, absorbance and mass spectrometry to provide an integrated system capable of delivering unprecedented structural information from complex samples. 

Fluidic and electrical interfacing of micro fluidic devices to themselves and to the environment ( world ) is a topic where investigations should have been started. 

An interface or housing for micro fluidic applications was designed and fabricated. The device, made of PEEK, allows facile non-permanent coupling of standard capillary tubing to silicon/glass micro mixer chips. No additional adhesive material was used to for a secure and tight interconnect [70],... 

To form a highly resistive interface between the ASIC surface and the fluidic system, a polymer layer of Cyclotene is deposited on the ASIC surface before fabrication of the polymeric micro fluidic system. Cyclotene has high electrical resistance and good chemical stability. The excellent transmission properties ranging... 

The concept presented here in much detail as an example of cooperative project work in micro structured reactor plant development is based on the bus system and simultaneously handles a number of tasks such as mechanical stability, fluidic flow and signal transmission. A key feature of the so-called backbone interface is its open architecture. It does not rely on standardized reactors or devices, thus allowing the combination of devices from various suppliers. A robust interface was developed which withstands high pressures and temperatures. Thermal cross-talk was minimized through the use of different heat-conducting materials. 

R 18] A modular set of devices was developed within the pChemTec project introduced above. It consists of a base plate which is identical for all four devices. This base plate acts as the fluidic interface to the piping and is equipped with a micro structured mixer. The base plate can be combined with a heated tube to deliver a mixer-tube reactor. A combination with a porous tube delivers a degasser unit. A combination with a membrane unit (not shown) or a settler results in an extraction device (Figure 4.58). 

The micro flow cell Golden Gate [125] can tolerate up to 66 bar at temperatures up to 200 °C. The cell volume amounts to 28 ml and fluidic interfaces are 1/16 in Swagelok capillary fittings. While the dimensions of the actual flow cell are only a few centimeters, the actual optical interface to a spectrometer consist of a macroscale table-top device with a clamping mechanism which positions the flow cell in the optical pathway. 

A fluidic interface was constructed to allow fast chip positioning, channel washing, and electrolyte filling [297]. A socket was designed for the chip-to-world interface, in which the open and closed states are shown in Figure 2.38 [298],... 

Carbon fiber electrodes ( 100 nm dia.) were also used to characterize the diffusion between adjacent stream zones at the interface between a micro fluidic system (16 channels 50 im wide, 57 im deep, separated by a 22- im wall) and a large volume using 10 mM ferrocyanide and amperometric detection [756]. It was reported that when the carbon fiber electrode was used in a PDMS chip, the in-channel format gave better peak symmetry than the end-channel format [757]. 

Sanders, J.C., Breadmore, M.C., Mitchell, P.S., Landers, J.P., A simple PDMS-based electro-fluidic interface for microchip electrophoretic separations. Analyst 2002, 127, 1558-1563. 

A complex PMMA-based fluidic device was built by Soper s research group [68], which coupled capillary nanoreactors to microseparation platforms (electrophoresis chips) for the generation of sequencing ladders and PCR products. The nanoreactors consisted of fused silica capillary tubes with a few tens of nanoliters of reaction volume, which can be interfaced wiht the chips via connectors micromachined in PMMA, using deep X-ray etching. A DNA tem-... 

The ability to fill a device with many different fluids in different channels and chambers allows for the implementation of a simple and robust geometric method of metering solutions. The principle behind this scheme is to set up a geometry in which two microfluidic chambers may be primed with different solutions and connected via a fluidic interface that is controlled by a microfabricated valve (Fig. 11.4). With a central interface valve closed, the two chambers are first deadend filled with two different solutions using the POP technique. Once both chambers have been completely filled, containment valves are actuated, isolating the chambers from the rest of the chip. The interface valve is then opened, creating a... 

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