Fluidic Devices

It has estimated that in the United States more than 16 million units per year of stored blood are required for transfusion purposes. There may be complications arising from the transfusion of blood components. 

A fluidic device has been fabricated by a 3D printing technology to get some analytical data. 3D-printed fluidic devices enable quantitative evaluation of blood components in modified storage solutions for use in transfusion medicine (49). 

Concrete additive (16) Celloxide 2021P Daicel Chemical 

Wikipedia, Chuck Hull — wikipedia, the free encyclopedia, 2014. [Online accessed 30-July-2014], 

Apparatus for production of three-dimensional objects by stereolithography, US Patent 4 575 330, assigned to UVP, Inc. (San Gabriel, CA), March 11,1986. 

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Commercial appHcations include substrates, fluidic devices, fine mesh screens, and magnetic head pads. 

Fig. 7. Illustration of an automated reagent introduction, reaction and analysis set-up based on the incorporation of a micro-fluidic device into a conventional HPLC system...

Link DR, Anna SL, Weitz DA, Stone, HA (2004) Geometrically mediated breakup of drops in micro fluidic devices. Phys Rev Lett 92 054503-1-4... 

White, I. M. Gohring, J. Sun, Y. Yang, G. Lacey, S. Fan, X., Versatile waveguide coupled opto fluidic devices based on liquid core optical ring resonators, Appl. Phys. Lett. 2007, 91, 241104... 

Microfabricated fluidic devices (microchips) are potentially useful for multidimensional separations because high-efficiency separations can be achieved and small sample volumes can be manipulated with minimal dead volumes between interconnecting channels. Electro-kinetically driven separation techniques demonstrated on microchips include... 

Rocklin, R. D., Ramsey, R. S., and Ramsey, J. M. (2000). A microfabricated fluidic device for performing two-dimensional liquid-phase separations. Anal. Chem. 72, 5244-5249. 

Basically, microfluidic devices involve the flow of liquid in the nanoliter range, and, hence they are useful devices in separation science at nano or low level analyses of various ingredients in biological and environmental matrices. The most important applications of micro-fluidic devices include medical, chemical, and separation sciences. 

Internal structures of micro devices (sometimes the micro device itself) are very small compared with conventional chemical equipment. However, micro fluidic devices are large enough that the physical laws established for the macroscopic world can be used to describe the behavior in the device. However, some additional terms must be taken into account, which are neglected in designing conventional reactors. An efficiency analysis of micro heat exchangers [46] is used to explain... 

Figure 4.5 Schematic of two possibilities of monitoring and adjusting temperature in a conventional batch reactor and a micro fluidic device [13] (by courtesy of S. Masebe, Kyoto University).

Fluidic and electrical interfacing of micro fluidic devices to themselves and to the environment ( world ) is a topic where investigations should have been started. 

Similar to computer technologies, so-called plug and play micro fluidic devices were developed. These devices are composed of a fluid driving unit and a polymer chip containing micro fluidic channels and reservoirs. The one and only connection is an electrical bus system which connects the chip with the external control unit. By filling the reservoirs with reagents, the chip can be used for performing chemical reactions or biochemical analysis [72],... 

The micro fluidic devices are integrated into cubic modules of identical shape and size, and can be easily replaced [108], The modules are equipped with individual temperature control, integrated pressure and/or temperature sensors and, upon demand, additional actors such as non-return valves. This modular concept ensures a flexible interconnection of the micro fluidic devices. 

Zanzucchi, P. J., Cherukuri, S. C., McBride, S. E., Etching to form cross-over, non-intersecting channel networks for use in partitioned microelectronic and fluidic device arrays for clinical diagnostics and chemical synthesis, US 5681484, David Sarnoff Research Center, Princeton, NJ, 1995. 

FIGURE 7.41 Picture of the microfabricated fluidic device integrated with a standard MALDI-TOF sample plate. Because of the self-activating character of the microfluidic device, the system can be introduced into the MALDI ionization chamber without any wire or tube for the sample introduction and the flow control [820]. Reprinted with permission from the American Chemical Society. 

Lee, H.H., Kuo, Y., A new micro-fluidic device for protein separation fabricated on a silicon substrate. Electrochem. Soc. Proc. 2001, 395-398. 

Chung, J.W., Grigoropoulos, C.P., Greif, R., Infrared thermal velocimetry in MEMS-based fluidic devices. J. Microelectromech. Syst. 2003, 12, 365-372. 

Roos, P., Skinner, C.D., A two bead immunoassay in a micro fluidic device using a flat laser intensity profile for illumination. Analyst 2003, 128, 527-531. 

Ferrigno, R., Lee, J.N., Jiang, X., Whitesides, G.M., Potentiometric titrations in a poly(dimethylsiloxane)-based micro fluidic device. Anal. Chem. 2004, 76, 2273-2280. 

Culbertson, C.T., Alarie, J.P., McClain, M.A., Jacobson, S.C., Ramsery, J.M., Rapid cellular assays on microfabricated fluidic device. Micro Total Analysis Systems, Proceedings 5th [iTAS Symposium, Monterey, CA, Oct. 21-25, 2001, 285-286. 

Shiddiky, M. J. A., Won, M. S. and Shim, Y. B. (2006), Simultaneous analysis of nitrate and nitrite in a micro fluidic device with a Cu-complex-modified electrode. Electrophoresis, 27(22) 4545 1554. 

A complex PMMA-based fluidic device was built by Soper s research group [68], which coupled capillary nanoreactors to microseparation platforms (electrophoresis chips) for the generation of sequencing ladders and PCR products. The nanoreactors consisted of fused silica capillary tubes with a few tens of nanoliters of reaction volume, which can be interfaced wiht the chips via connectors micromachined in PMMA, using deep X-ray etching. A DNA tem-... 

Diffusion as an Efficient Means of Transport in Micro- and Nanoscale Chemical Reactors fesT—Driven Fluidic Devices... 

Figure 10-4 Design of an asymmetric turn used in microchip-based capillary electrophoresis system constructed in glass.The design facilitates the maintenance of sample integrity during flow in a microchannel around a curve.The dimensions are indicated on the figure and are taken from the tops of the channels.The channels were filled with black ink for contrast (From Ramsey JD, Jacobson SC, Culbertson CT, Ramsey JM. High efficiency, two-dimensional separations of protein digests on micro fluidic devices.

Everett TA, Higgins DA (2009) Electrostatic self-assembly of ordered perylene-diimide/ polyelectrolyte nanofibers in fluidic devices from nematic domains to macroscopic alignment. Langmuir 25(22) 13045-13051... 

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