Capillary Separations

Kasicka, V., Pruslk, Z., Sazelova, P., Jiracek, J. and Barth, T., Theory of the correlation between capillary and free-flow zone electrophoresis and its use for the conversion of analytical capillary separations to continuous free-flow preparative processes. Application to analysis and preparation of fragments of insulin, ]. Chromatogr. A, 796, 211, 1998. 

General applications While capillary separation methods produce peak capacities, n, numbered in hundreds, many real-world mixtures (e.g. in the petroleum industry) require values of 104. This can only... 

TWO-DIMENSIONAL CAPILLARY SEPARATIONS FOR ANALYSIS OF PEPTIDES AND PROTEINS... 

Capillary rheology tests, 19 578 Capillary separations, 4 602-647 sample preparation, 4 609-610 Capillary viscometers, 21 726-731 commercial, 21 729 uses of, 21 727... 

Kennedy RT, Watson CJ, Haskins WE, Powell DH, Strecker RE. 2002b. In vivo neurochemical monitoring by microdialysis and capillary separations. Curr Opin Chem Biol 6 (5) 659-665. 

Capillary electrophoresis ofV-2 at pH 2.3 and pH 7.2. Inserts ultraviolet spectra (190-350 nm) of selected fractions. Capillary separation at -30kV with diode array detection. 

Finally, for passage into the blood, the molecules have to pass the endothehal membrane of the capillaries, separating the interstitial space from the blood. The endothehal membrane is considered to be much leakier than the epithehal membrane. Therefore it is not considered as a major barrier during drug absorption. 

Capillary separation methods have been applied to the analysis of drugs (45-49) and of liposomes, microsomes, and viruses (34,50-53). De-... 

Applications of LC-NMR are still scarce but the technique will become more widely used. The main effort for efficient exploitation of LC-NMR needs to be made on the chromatographic side, where strategies involving efficient preconcentration, high loading, stop-flow, time slicing, or low flow procedures have to be developed. Microbore columns or capillary separation methods, such as capillary LC-NMR, CE-NMR, and CEC-NMR, will find increased application, one reason being that the low solvent consumption will allow the use of fully deuterated solvents. 

E. S. Yeung and W. G. Kuhr, Indirect Detection Methods for Capillary Separations, Anal. Chem. 1991, 63, 275A J. Ren and X. Huang, Indirect Chemiluminescence Detection for Capillary Electrophoresis of Cations Using Co(III) as a Probe Ion, Anal. Chem. 2001, 731, 2663 M. Macka, C. Johns,... 

Capillary rise is the elevation of liquid in a capillary tube above the general level. Capillary separation is the separation of gases by flow through a porous medium, in a theory of this process based on the concept of momentum transfer, the actual porous medium is treated as equivalent to a bundle of parallel capillary lubes. 

Interference type This technique has been proposed by Tarigan (66) for RI detection in capillary separation. 

Figure 7.3.2.1 shows the current experimental arrangement employed in Tubingen for capillary separations. A capillary HPLC pump is placed at a distance of about 2.5m from the 14T (proton resonance frequency, 600 MHz) cryomagnet,... 

The use of capillary separations, an NMR probe that contains multiple coils, and the associated capillary fluidics to deliver the samples to and from the coils is the next step in probe development. A future exciting development will be the interfacing of such intelligent NMR probe and fluidic systems with other integrated detection modalities such as fluorescence, absorbance and mass spectrometry to provide an integrated system capable of delivering unprecedented structural information from complex samples. 

Fig. 2.22. Coupling of capillary separation techniques with NMR (taken from Ref. [72] with permission of the publisher).

Direct injection nebulizers are operated without a spray chamber. Instead, the concentric, pneumatic nebulizer is positioned just below the plasma and 100% of the sample is sprayed into the ICP. The nebulizer replaces the center tube of the ICP torch. The direct injection nebulizers are particularly attractive for the analysis of small sample volumes and for elements, such as Hg, I, and B, that stick to surfaces in the spray chamber and therefore have long washout times when a spray chamber is used. The dead volume of the direct injection nebulizers is small, so they have often been used to couple capillary separations with ICP-MS detec-... 

E.S. Yeung and W.G. Kuhr, Indirect detection methods for capillary separations, Anal. Chem., 63, A275-282A (1991). 

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