Infertility ovulation induction

Follitropin treatment for infertility has been reviewed in detail (1,2). Multiple pregnancy occurs in 20% of patients, 80% being twin pregnancies. There is no documented increase in congenital abnormalities in children conceived after ovulation induction with follitropin. 

Couples with a multitude of infertility problems, including unidentified causes and persistent infertility despite standard treatments, may benefit from assisted reproductive techniques. Standard initial therapy consists of ovulation induction and artificial insemination for at least 6 months before progressing to more expensive and exotic techniques. 

Seibel MM. Ovulation induction widi foUicle-sthnulating hormone. In Seibel MM, ed. Infertility ... 

In view of the notion that chemotaxis is required for the selection of capacitated spermatozoa, faulty precontact sperm-egg communication may be one of the causes of male infertility, female infertility, or both. It is reasonable that, in the future, chemotaxis may be exploited as a diagnostic tool for sperm quality and male infertility and may be used as a biological sperm-selection procedure before in vitro fertilization, especially before intracytoplasmic single sperm insertion or for intrauterine insemination. Moreover, the chemotactic activity of a follicular fluid may be an effective way to monitor the possible effects of different ovulation induction protocols on the maturational status of oocytes aspirated for in vitro fertilization [2]. On the other hand, interference vwth sperm chemotaxis may represent an exciting new approach to contraception. 

B. Ovulation Induction - Anti-estrogenic activity, in addition to causing infertility, has also been claimed to be a means for inducing ovulation. 

Indications Development of multiple follicles in ovulatory patients and the induction of ovulation and pregnancy in anovulatory infertile patients... 

B. Indications and nse Follistim is indicated for the development of multiple follicles in ovulatory patients participating in an assisted reproductive technology program. It is also indicated for the induction of ovulation and pregnancy in anovulatory infertile patients in whom the cause of infertility is functional and not due to primary ovarian failure. 

Clomiphene is a very weak non-steroidal estrogen it blocks the feedback effect of endogenous estrogens on the pituitary, promoting the further secretion of gonadotropins. The primary use of clomiphene in women is in the induction of ovulation. In men, it has been used to treat infertility in view of its ability to increase endogenous production of testosterone (1). 

Yokoi N, Uemura T, Murase M, Kondoh Y, Ishikawa M, Hirahara F. A modified hMG-GnRH method for the induction of ovulation in infertile women with severe hypogona-dotropic amenorrhea. Endocr J 2002 49(2) 159-64. 

Induction of ovulation 177 Infertility 180 Pregnancy 182 Parturition 185 Lactation 186 Postpartum problems 187... 

Induction of Ovulation - Fallout from the recent emphasis on work on antifertility has been a tool for the treatment of infertility due to ovulatory failure. The use of clomiphene citrate (35) for this clinical condition has met with a good measure of success a double blind study demonstrated that the response was indeed a drug effect." Though the exact mechanism of action of this agent is not clear, it has been shown to increase the estrogen output in women without increasing urinary gona-... 

Intrauterine insemination (lUI) involves induction of ovulation, followed by transfer of motile sperm directly into the uterine cavity. This type of procedure is indicated if erectile dysfunction or male infertility (low motility, count, and/or poor morphology) has been identified, if the cervical environment is not conducive for effective sperm motility and/or sustenance, and if there are any physiological dysfunctions (93). 

Z2. Zarate, A., Canales, E., Schally, A. V., Ayala-Valdes, L., and Kastin, A. J., Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatory infertility. Fert. SterU. 23, 672-674 (1972). 

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