Increased duration

These restrictions do not apply to the less intense fluorescent tubes installed in the UVIS or MinUVIS (Fig. 6) or Universal UV lamps (Fig. 7). Black glass surrounds or screens serve as filters. Unfortunately account is often not taken of the fact that the transparency for short-wavelength UV light decreases appreciably with increasing duration of irradiation (Fig. 8). So it is advisable to change the filters of lamps intended for short-wavelength radiation at regular intervals. They can... 

Although these divisions are of historical interest, duration of action, especially with a single dose, depends more on distribution effects than on elimination half-life. Furthermore, as the dose increases, duration of action is prolonged. In addition, the availability of these drugs in the United States is limited. 

Gel-Forming Solutions. One disadvantage of solutions is their relatively short residence time in the eye. This has been overcome to some degree by the development of solutions that are liquid in the container and thus can be instilled as eyedrops but gel on contact with the tear fluid and provide increased contact time with the possibility of improved drug absorption and increased duration of therapeutic effect. 

Although, there was a net increase in the conductance of solution with increasing duration of sonication, but two opposing factors contributed significantly as under ... 

Incorporation of fluorine at a site adjacent to a "metabolic soft spot" has also been used as a strategy to increase duration of action. Linopir-dine (24) was among the first clinical compounds that enhanced potassium-evoked release of acetylcholine in preclinical models of AD [22]. Linopirdine showed no clinical efficacy and its human pharmacokinetic profile was suggested as the reason for this lack of clinical efficacy. Specifically noted was the molecule s poor brain exposure and short half-life due to formation of the N-oxides 25 and 26 (Table 3) [23,24]. Optimization of 24 resulted in replacement of the indolone core by the anthracenone 27, which had improved in vitro activity, but still exhibited a short duration of action. To improve the metabolic stability, fluorine... 

Velakoulis, D., Wood, S. J., Smith, D. J. et al. Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia. Schizophr Res. 57 43-49, 2002. 

However, the microbial activity is depressed during long and severe wintertime, and this leads to an accumulation of semi-mineralizable plant residues on the soil surface. With the increasing duration of cold season from south to north, the mass of these half-destroyed remains enlarges from 15 ton/ha of dry organic matter in Broad-Leaved Sub-Boreal Forest ecosystems to 80-85 ton/ha in Northern Taiga Forest ecosystems. 

ACT-078573 (20) is the first oral orexin receptor antagonist that penetrates the blood-brain barrier and is capable of inducing a transient and reversible blockade of the two receptors, 0X1 and 0X2 [61]. In animal models, the administration of 20 resulted in a dose-dependent decrease in alertness and increased non-REM and REM sleep. The compound, administered at oral doses ranging from 10 to 300 mg/kg, dose-dependently decreased alertness in rats and exhibited increased duration of REM and non-REM sleep, indicating no intrusive REM sleep that is characteristic of narcolepsy. In dogs, treatment with 20 (10-100 mg/kg p.o.) resulted in dose-dependent reductions in mobility and also induced signs of clinical somnolence. 

Increased duration of exposure to inhaled cyanide in mice resulted in lower LC50 values (Higgins et al. 1972 Matijak-Schaper and Alarie 1982). Additionally, cyanide toxicity was influenced by dilution of the gavage dose. Greater dilution resulted in higher mortality for the same total dose (Ferguson 1962). 

Wu JC, Bell K, Najafi A, Widmark C, Keator D, Tang C, Klein E, Bunney BG, Fallon J, Bunney WE. (1997). Decreasing striatal 6-FDOPA uptake with increasing duration of cocaine withdrawal. Neuropsychopharmacology. 17(6) 402-9. 

First, there is no way to know whether, within each country, those groups of people who eat more meat exhibit greater rates of colon cancer than those who eat less or even no meat. Data concerning total or average meat consumption provide no clues about how that consumption is distributed among members of the population moreover, the distribution patterns in different countries are surely variable. The data are also uninformative on the question of duration of meat consumption - they do not reveal whether rates rise with increasing duration of meat intake. 

The timing diagrams of the thermally balanced NP and PP sequences are shown in Fig. 27. Comparing them with those of the corresponding unbalanced sequences, one notices immediately the price to be paid for the improved thermal performance consisting in an increased duration of each cycle (particularly those with small x values) which makes the experiments longer by a factor of about 2. 

Several captopril-like drugs are now available, their main advantages over captopril being their increased duration of action, e.g. enalapril. 

In an epidemiological study of 1345 workers potentially exposed to acrylonitrile and followed for 10 or more years there was a greater than expected incidence of lung cancer (8 obs. vs. 4.4 exp.)." A trend toward increased risks of cancer of all sites was also observed with increased duration of exposure and with higher severity of exposure. However, in a follow-up of this cohort through 1983 the only statisti-... 

A mortality study of 1014 men employed between 1937 and 1971 in a Texas antimony smelter found increased mortality from lung cancer (standardized mortality ratio 1.39) and a positive trend in mortality with increasing duration of exposure. The data also suggested some increased mortality from nonmalignant respiratory heart disease in these workers. 

Tolerance to repeated or sublethal exposures of disulfoton has been demonstrated. Typically, the cholinergic symptoms (tremors, fasiculations, excessive salivation) disappear with increasing duration of exposure but the acetylcholinesterase activity remains depressed. 

Exposure to the vapor causes irritation of the eyes, nose, and throat, severe headache, and nausea. Lindane levels in the blood do not appear to increase with increased duration of exposure but primarily reflect recent lindane absorption. Production workers exposed to air levels of 31-1800 J,g/m had blood levels of 1.9-8.3ppb. ... 

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