Immune reactivity

Kimber, I. et al., Assessment of protein allergenicity on the basis of immune reactivity animal models,. Environ. Health Perspect., Ill, 1125, 2003. 

At least two specific properties make the immune system vulnerable to chemical or physical insults (1) the immune system develops rather late in life (thymus development lasts at least until puberty), and some bone marrow-dependent immune components are continuously renewed (i.e., granulocytes), and (2) each pathogen attack, as well as immune surveillance, demands a delicate control of the balance between activation, silencing, and regulation of immune reactivity. 

Deleplanque, B. et al., Modulation of immune reactivity by unilateral striatal and meso-limbic dopaminergic lesions, Neurosci.Lett., 166, 216, 1994. 

Herzog, D. et al, Study of immune reactivity of minocycline-induced chronic active hepatitis. Dig. Dis. Sci., 42, 1100, 1997. 

Marsland, A.L. et al., Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults, Health Psychol., 20, 4, 2001. 

Kimber, I., Dearman, R.J., Penninks, A.H., Knippels, L.M.J., Buchanan, R.B., Hammer-berg, B., Jackson, H.A. and Helm, R.M., Assessment of protein allergenicity on the basis of immune reactivity animal models. Environ. Health Perspect., Ill, 1125, 2003. 

Zinkernagel RM, et al. Antigen localisation regulates immune responses in a dose- and time-dependent fashion a geographical view of immune reactivity. Immunol Rev 1997 156 199. 

The anti-idiotypes in the reovirus system resemble hemagglutinin neutralization domains. Functionally shown here is the consequence of administering monoclonal anti-idiotypic proteins to mice. A variety of reovirus specific immune reactivities are induced. 

Basophils and Eosinophils. These two types of granulocyte represent only a small proportion of the circulating leukocytes. The basophil possesses receptors specific for the Fc portion of IgE molecules. It is involved in allergic reactions and can play a role in the clinical state of anaphylaxis, which is a life-threatening allergic response. Eosinophils are involved with the immune reactivity of drug allergies and with the body s immune response to parasitic infestations such as worms (see chapter 9). 

Potentized homeopathic medicines have preferential action on sides of the body some are more effective on one side than on the other. This differential effect of the medicines with respect to laterality can be traced to functional asymmetry of the human brain. The brain can asymmetrically modulate nurochemical, neuroendocrine and immune reactivity. Potentized drugs are very often selected on the basis of time modalities of symptoms of a disease. The time modalities of the drug action can be correlated with the internal clock or biological rhythms of organisms which are disturbed in diseased conditions. Melatonin, secreted in the brain, has marked influence on the circadian rhythms. 

Leukotrienes increase vascular permeability, wall recruitment of leukocytes, endothelial-cell dysfunction, proliferation of smooth-muscle cells, immune reactivity and mediated vascular inflammation, and atherosclerosis (43). 

Katon, W. J., Richardson, L., Lozano, P., and McCauley, E. (2004b). Differences in Immune Responses and immune Reactivity to Stress in Adults. Biological Research For Nursing Vol. 5, (No. 4), 243-254. 

Paimela L, Kurki P, Leirisalo-Repo M, Piirainen H. Gliadin immune reactivity in patients with rheumatoid arthritis. Clin Exp Rheumatol 1995 13 603-607. 

Q14 It is possible but unlikely. There is evidence of a genetic predisposition to celiac disease and the onset of symptoms can be triggered in susceptible individuals by an environmental event. The amount of gluten that can be taken by a susceptible individual, without provoking symptoms, varies greatly some patients are much more sensitive than others and the immune reactivity... 

The fact that immunosuppressant therapy has not been proven to halt progression has been cited as evidence against an immune-mediated mechanism of motor neuron injury. However, several potential explanations for this lack of efficacy could exist. Immune suppression may be too little and too late. By the time symptoms and signs appear, extensive CNS damage may already have occurred due to increased calcium and free radicals, and it may be difficult to stop the process that the immune reactivity initiated. Further, immunosuppression therapies may not adequately access the CNS and... 

Alexianu ME, Kozovska M, Appel SH (2001) Immune reactivity in a mouse model of familial ALS coirelates witli disease progi ession. Neurology 57 1282-1289. 

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