Time modalities

Before describing the details of the mechanism of action of homeopathic potencies in the living system we would discuss first the scientific basis of some aspects peculiar to Homeopathy. These are lateralities, time modalities, similia principle, non-linear systems, miasms, polycrests and holism. 

Potentized homeopathic medicines have preferential action on sides of the body some are more effective on one side than on the other. This differential effect of the medicines with respect to laterality can be traced to functional asymmetry of the human brain. The brain can asymmetrically modulate nurochemical, neuroendocrine and immune reactivity. Potentized drugs are very often selected on the basis of time modalities of symptoms of a disease. The time modalities of the drug action can be correlated with the internal clock or biological rhythms of organisms which are disturbed in diseased conditions. Melatonin, secreted in the brain, has marked influence on the circadian rhythms. 

Intracardiac echocardiography is emerging as an ideal real-time modality to guide intracardiac interventional procedures. ICE allows accurate appreciation of cardiac anatomy and detailed visualization of specific anatomic structures, the most important factors in planning and guiding catheter-based interventional techniques [15-17]. In our daily practice, ICE is performed using a commercially available 9-F/9 MHz ultra-ICE catheter-based ultrasound transducer (EP Technologies, Boston Scientific, San Jose, CA, USA). The Ultra ICE catheter is introduced percutaneously into the... 

Logics combining transaction-time and valid-time modalities for modeling the evolution of temporal databases. 

Before the administration of naloxone, the nurse obtains the blood pressure, pulse, and respiratory rate and reviews the record for the drug suspected of causing the overdosage. If there is sufficient time, the nurse also should review the initial health history, allergy history, and current treatment modalities. 

Epidermal growths such as actinic keratosis, lentigines or thin seborrheic keratoses can all be treated effectively with 25-35% TCA peels. Thicker epidermal growths or growths involving the dermis will be more resistant to treatment such as hypertrophic actinic keratoses and thicker seborrheic keratoses and may even be resistant to a medium-depth peel. Resistant lesions many times are best treated with a combination of a medium-depth chemical peel and other modalities such as manual dermasanding or CO, laser. 

Planning for dialysis should begin when creatinine clearance falls less than 30 mL/minute/1.73 m2 (stage 4 CKD),1 when progression to ESRD is inevitable, to allow time to educate the patient and family on the treatment modalities and establish the appropriate access for the modality of choice. Ideally, initiation of dialysis should be done at a point when the patient is ready to undergo treatment, rather than when the patient is in emergent need of dialysis. 

The preferred route of administration is intraperitoneal (IP) rather than IV to achieve maximum concentrations at the site of infection. Antibiotics can be administered IP intermittently as a single large dose in one exchange per day or continuously as multiple smaller doses with each exchange. Intermittent administration requires at least 6 hours of dwell time in the peritoneal cavity to allow for adequate systemic absorption and provides adequate levels to cover the 24-hour period. However, continuous administration is better suited for PD modalities that require more frequent exchanges (less than 6-hour dwell time). The reader should refer to the ISPD guidelines for dosing recommendations for IP antibiotics in CAPD and automated PD patients.49 The dose of the antibiotics should be increased by 25% for patients with residual renal function who are able to produce more than 100 mL urine output per day. 

Clinical trials combining chemotherapy and immunotherapy are based on the observations of independent clinical activity of each of these treatment modalities in treating metastatic MM. This combination is known as biochemotherapy. Only one phase III clinical trial showed significant improvement in response rate, time to progression, and median survival favoring the biochemotherapy arm versus the combination-chemotherapy arm.59 Currently, the use of biochemotherapy is not justified outside a clinical trial in patients with stage IV MM.53,58,60... 

As we stated above, there is a risk involved in the use of the Cheng-Prusoff relationships for SAR studies, as it is possible that structural alterations of the lead analogues could change the inhibition modality. This can be check from time to time for compounds that represent the greatest structural excursions from the lead molecule. Additionally compounds that are destined for progression into cellular and animal models should have their inhibition modality and affinity confirmed by running the more comprehensive studies discussed in Section 5.3. 

---