Vascular mediators

Therapeutics A number of potent small molecule antagonists for av 33 integrin are under preclinical investigations for various angiogenesis or vascular-mediated disorders [10]. 

Hill, S. A., Williams, K. B., and Denekamp, J. (1992) A comparison of vascular-mediated tumor cell death by the necrotizing agents GR63178 and flavone acetic acid. Inti. J. Radiat. Oncol. Biol. Phys. 22,437 441. 

We have extensively studied these vascular mediators and generation of such mediator triggered by cancer cells directly or indirectly. It is interesting to note that they are common to inflammatory mediators consequently, one can observe that cancer is like inflammation that never ceases but grows. 

Fig. 5 A comprehensive network of vascular mediators bradykinin, NO, and others are involving EPR effect in infection, inflammation, and cancer (taken from [117] after modification)...

Extensive producticm of vascular mediators that facilitate extravasmion... 

Figure 4, Kinin generating cascade and various vascular mediators in cancer tissues affecting the EPR effect. Mediators, enzymes, and inhibitors are shown. See text for details. M, macrophage PMN, polymorphoneuclear cells COXs, cyclooxygenases PCs, prostaglandins. SBTl, soybean trypsin inhibitor (Kunitz type) ONOO", peroxynitrite NO, nitric oxid MMP, matrix metalloproteinases.

Besides VPF (VEGF) and bradykinin system, many other factors involve in the EPR effect in solid tumor. Figure 4 shows various vascular mediators and their interaction for regulating tumor blood flow and vascular permeability. 

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