Humoral immunity modulation

Yamashita reported anti-inflammatory effect of astaxanthin when administered with aspirin. An oral preparation has been developed by Alejung and Wadstroem for the treatment of Helicobacter infections of the mammalian gastrointestinal tract. Strong evidence suggested that astaxanthin modulated the humoral and non-humoral immune systems. It enhanced the release of interleukin-1 and tumor necrosis factor-... 

Me Cabe MJ Jr. Metropolitan Center for Higher Technology, Detroit, Ml Mechanisms and consequences of Pb modulation of cell-mediated and humoral immunity (in vitro culture system mice in vivo) National Institute of Environmental Health Sciences... 

He, E, Tuomoloa, E., Arvilommi, H., and Salminen, S. 2000. Modulation of humoral immune response through probiotic intake. FEMS Immunol Med Microbiol 29 47-52. 

The potential modulation of immune system responses by GMP is also discussed in the article by Brody (2000). A number of studies have shown that GMP stimulates the proliferation of normal human B-lymphocytes, but not of T-lymphocytes. This would indicate that GMP upregulates the humoral immune system with a subsequent increase in the production of IgA antibodies, in particular. Moreover, GMP appears to specifically affect the production of various cytokines. It is clear that further research is required in this field so as to elucidate the significance of GMP for the immune system. 

Ray, A., Mediratta, P.K., Sen, P. (1992). Modulation by naltrexone of stress induced changes in humoral immune responsiveness and gastric mucosal integrity in rats. Physiol. Behav. 51 293-6. 

Stein GM, Berg PA. Modulation of cellular and humoral immune responses during exposure of healthy individuals to an aqueous mistletoe extract. Eur J Med Research 1998 3(6) 307-314. 

LawrenceDA. 1981. Heavy metal modulation of lymphocyte activities. I./ vitro effects of heavy metals on primary humoral immune responses. Toxicol Appl Pharmacol 57 439-451. 

IL-5, and IL-13, and are involved in the development of humoral immunity protecting against extracellular pathogens (Fig. 18.1-6). On the other hand, uncontrolled Thl responses are associated with inflammatory or autoimmune pathologies such as rheumatoid arthritis (RA), insulin-dependent diabetes mellitus (IDDM), or psoriasis and excessive Th2 responses are associated with allergies and asthma [65]. This indicates that the development of Thl and Th2 cells must be tightly controlled and that therapeutic modulation of immune responses may have an impact on human diseases. 

These data indicate that garlic and AGE can modulate not only the cell-mediated immune response but also the humoral immune response through the stimulation of a variety of immuno-responder cells. 

Banerjee, B.D., Koner, B.C., Ray, A., 1997. Influence of stress on DDT-induced modulation of the humoral immune responsiveness in mice. Environ. Res. 

Other investigators have studied the immune modulating effects of probiotics as a means of reducing diarrhea, suggesting that the humoral immune system plays a significant role in the probiotics effect. 

Gahery-Segard H, Juillard V, Gaston J, etal. Humoral immime response to the capsid components of recombinant adenoviruses routes of immunization modulate virus-induced Ig subclass shifts. Eur J Immimol 1997 27 653-659. 

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