Humanized mouse models

In addition, stndies evaluating interferon alpha/beta and interlenkin-16 expression have shown snbstantial antiviral effects against HlV-1 in vitro and in a humanized mouse model (Cremer et al. 2000 Lanret et al. 1994 Sanhadji et al. 1997 Zhou etal. 1997). 

Miksys SF, Cheung C, Gonzalez FJ, Tyndale RF. 2005. Human CYP2D6 and mouse CYP2DS organ distribution in a humanized mouse model. Drug Metab Dispos 33 1495-1502. 

Previous attempts to measure immune function of human cells following PBMC engraftment of immunodeficient mice have been met with limited success (34). The lack of a vigorous primary immune response mediated by human PBMC engrafted into earlier humanized mouse models was associated with host murine NK cell activity and other innate immune function as well as an overwhelming xenogeneic GVHD response of the... 

CASE EXAMPLE TRANSGENIC HUMANIZED MOUSE MODELS FOR HYPERLIPIDEMIA... 

The humanized mouse model is used for safety assessment of drugs that affect lipid profiles as a side effect (and thereby possibly influence the risk of atherosclerosis and, subsequently, myocardial infarction). A typical example is the disturbed lipid profile and increased risk of myocardial infarction experienced by AIDS patients following the long-term use of HIV-l-protease inhibitors [16,17]. 

Morosan, S., Flez-Deroubaix, S., Lunel, F., Renia, L., Giannini, C., Van Rooijen, N., Battaglia, S., Blanc, C., Eling, W., Sauerwein, R., Flannoun, L., Belghiti,., et al. (2006). Liver-stage development of Plasmodium falciparum, in a humanized mouse model. ]. Infect. Dis. 193, 996-1004. 

Zhang L, Kovalev GI, Su L. HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood 2007 109 2978-2981. 

Taneja V David CS. HLA transgenic mice as humanized mouse models of disease and immunity. J Clin Invest 1998 101 921-926. 

C. T. et al (2011) A genetically humanized mouse model for hepatitis C virus infection. Nature, 474, 208—211. 

The relevance of the activation of all of these procarcinogens can be addressed in a P450 2A13-humanized mouse model [520]. 

For a review of bothP450 5A1 inhibitors and thromboxane receptors, which have been used together, see [1691]. Quantitative stracture-ac-tivity relationships of both have been reviewed [1692]. Among the uses for P450 5A1 inhibitors are platelet function [1693], atherosclerosis [1694], inflammatory bowel disease [1695], lung cancer [1696], and production of hepatitis C virus (in a humanized mouse model) [1697]. 

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