Humanity principle

The most scientific approach is to replicate, in an appropriate animal, the type of dosing that would be expected to be used in humans, employing the dose for dose animal to human principle. A single, suitable animal species should suffice. If viral vectors are used, the animal species should be sensitive to infection by the wild-type virus. Studies should not automatically be done in primates but, initially, the commonly used laboratory species should be utilized. Only if those are demonstrated to be unsuitable should the next step be to consider the use of a primate. 

I am aware of the argument about relative levels of suffering. Doctor. I just find it depressing that after seven centuries of adhering to the scientific method we haven t come up with a more humane principle. I find the prospect of experimenting on people to be abhorrent."... 

Gibbs, M. (2003) Eco tower glass towers are not necessarily eco friendly. This one shows how new architecture can be evolved from ecological and humane principles . Architectural Review, August, 58-63. 

Recovery nd Purifica.tion. The production of EH Lilly s human insulin requires 31 principal processing steps of which 27 are associated with product recovery and purification (13). The production process for human insulin, based on a fermentation which yields proinsulin, provides an instmctive case study on the range of unit operations which must be considered in the recovery and purification of a recombinant product from a bacterial fermentation. Whereas the exact sequence has not been pubUshed, the principle steps in the purification scheme are outlined in Figure la. 

Monitoring by Electromechanical Instrumentation. According to basic engineering principles, no process can be conducted safely and effectively unless instantaneous information is available about its conditions. AH sterilizers are equipped with gauges, sensors (qv), and timers for the measurement of the various critical process parameters. More and more sterilizers are equipped with computerized control to eliminate the possibiUty of human error. However, electromechanical instmmentation is subject to random breakdowns or drifts from caUbrated settings and requires regular preventive maintenance procedures. 

The design of these devices is based on biological principles of organization of human olfactory and tasting abilities. 

Ceruloplasmin (from human blood plasma) [9031-37-2] Mr 134,000. This principle Cu transporter (90-90% of circulating Cu) is purified by precipitation with polyethylene glycol 4000, balchwise adsorption and elution from QAE-Sephadex, and gradient elution from DEAE-Sepharose CL-6B. Ceruloplasmin... 

Operations and human factors specialist involvement is important to find optimum solutions to human factors/ergonomics issues. Applying inherent safety principles to ergonomics/human factors issues can reduce risks associated with ... 

The CPI would benefit from the application of human factors principles to improve safety, quality, and productivity. These arise from applying quality management to get at the underlying causc-.s of errors rather than after-the-fact blame or punishment. Crosby (1984) advocates error cause... 

The information in this book is collected from published and unpublished literature. Responsibility for the accuracy of this material is disclaimed, however, responsibility is accepted for the selection, organization, and presentation. The vastness of the information necessitates selectivity in the attempt to make a comprehensive and cohesive presentation. The material is selected to illustrate a procedure or principle not advocacy. Every effort toward objectivity was made to balance human health and safety, environment, economic welfare, and civilization. 

Physiologically based toxicokinetic models are nowadays used increasingly for toxicological risk assessment. These models are based on human physiology, and thus take into consideration the actual toxicokinetic processes more accurately than the one- or two-compartment models. In these models, all of the relevant information regarding absorption, distribution, biotransformarion, and elimination of a compound is utilized. The principles of physiologically based pharmaco/ toxicokinetic models are depicted in Fig. 5.41a and h. The... 

FIGURE 5.56 The threshold region for chronic dose-response curves. [Reprinted with permission from Tardiff, R.G., and Rodricks, J.V. (1987). (Eds.), Toxic Substances and Human Risks Principles of Data Interpretation. New York Plenum Press.]... 

Ventilation noise and the annoyance effects which may result have been a recurring question in recent years for researchers, occupational health services, and various aurhorities. In spite of this, there are still major shortcomings in our knowledge about the links between human effects and exposure to ventilation noise. Current regulations and recommendations are thus based on uncertain principles in certain respects. 

ISO EN 9886 presents the principles, methods, and interpretation of measurements of relevant human physiological responses to hot, moderate, and cold environments. The standard can be used independently or to complement other standards. Four physiological measures are considered body core temperature, skin temperature, heart rate, and body mass loss. Comments are also provided on the technical requirements, relevance, convenience, annoyance to the subject, and cost of each of the physiological measurements. The use of ISO 9886 is mainly for extreme cases, where individuals are exposed to severe environments, or in laboratory investigations into the influence of the thermal environment on humans. 

Demand-controlled ventilation (DCV) is one approach to reduce energy consumption due to ventilation, that is gaining popularity in both industrial and nonindustrial applications. It is used in cases where ventilation requirements vary with time, regularly or irregularly. The control is based on a specified level of indoor air quality by means of continuous measurement of the parameters, that are expected to primarily determine the lAQ, such as the concentration of the main contaminant liberated from the production process. The principle is thus similar to the one in some better-known nonindustrial applications, e.g., CO2 levels in rooms with dense human occupancy (theaters, classrooms, etc.) or nicotine concentration in smoking rooms. See also Section 9.6. 

Table 13.1 covers general information for different particulates, liquids in gas, typical particles and gas dispersoids, behavior of particles in the human body, charging mechanisms, principles of particle size analysis, methods for particle size analysis, and an estimation of the general collection efficiency of available commercial particle removal equipment. 

The book begins with a discussion of the theories of error causation and then goes on to describe the various ways in which data can be collected, analyzed, and used to reduce the potential for error. Case studies are used to teach the methodology of error reduction in specific industry operations. Finally, the book concludes with a plan for a plant error reduction program and a discussion of how human factors principles impact on the process safety management system. 

Chapter 8, A Systematic Approach to the Management of Human Error, explains how the manager and safety professional can use human factors principles in the management of process safety. This chapter also provides a practical plan for a plant human error reduction program that will improve productivity and quality as well. 

The major benefits that arise from the application of human factors principles to process operations are improved safety and reduced down time. In addition, the elimination of error has substantial potential benefits for both quality and productivity. There is now a considerable interest in applying quality management approaches in the CPI. Many of the major quality experts em-... 

From the traditional HF/E perspective, error is seen as a consequence of a mismatch between the demands of a task and the physical and mental capabilities of an individual or an operating team. An extended version of this perspective was described in Chapter 1, Section 1.7. The basic approach of HF/E is to reduce the likelihood of error by the application of design principles and standards to match human capabilities and task demands. These encompass the physical environment (e.g., heat, lighting, vibration), and the design of the workplace together with display and control elements of the human-machine interface. Examples of the approach are given in Wilson and Corlett (1990) and Salvendy (1987). 

This factor refers to the spatial organization of the information displays. In general, instruments displaying process parameters that are functionally related should also be physically close. In this way, it is likely that a given fault will lead to a symptom pattern that is easier to interpret than a random distribution of information. Although violation of this principle may not induce errors in a direct manner, it may hinder human performance. The following example illustrates this point. 

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