Human Rhesus

Foster RH, Wagstaff AJ (1998) Tetravalent human-rhesus reassortant rotavirus vaccine - A review of its immunogenicity, tolerability and protective efficacy against paediatric rotavirus gastroenteritis. Biodrugs 9(2) 155-178... 

Cook NS, Zerwes H-G, Tapparelli C et al. (1993) Platelet aggregation and fibrinogen binding in human, rhesus monkey, guinea-pig, hamster and rat blood activation by ADP and thrombin receptor peptide and inhibition by glycoprotein Ilb/IIIa antagonists. Thromb Haemostasis 70 531-539... 

Beilstein MA, Whanger PD. 1983. Distribution of selenium and glutathione peroxidase in blood fractions from humans, rhesus and squirrel monkeys, rats and sheep. J Nutr 113 2138-2146. 

H. B., and VandenHeuvel, W. J. A. Metabolism of Carbidopa, (-)-L-a-Hydrazino-3,4-dihydroxy-a-methyl-benzenepropanoic Acid Monohydrate, in the Human, Rhesus Monkey, Dog, and Rat... 

Peripheral nervous system axonal degeneration has been a consistent finding following Pb exposure in humans/ rhesus monkeys/ and guinea pigs. Lead exposure in developing animals results in a reduction in the diameter of rat pyramidal tract axons. Similar findings of reduced axonal size were observed in the optic nerves of Pb-exposed mice. ... 

Worek, R, Aurbek, N., Wille, T., et al., 2011. Kinetic analysis of interactions of paraoxon and oximes with human. Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase. Toxicol. Lett. 200, 19-23. 

Dinitropyrene Salmonella typhimurium. Human, Rhesus Monkey and Rat intestinal microflora. 1 -Amino-8-nitropyrene, 1,8-Diaminopyrene, 1 -N-Acetyl-8-nitropyrene, N-N-Diacetyl-1,8-diaminopyrene. 9,31,32, 33, 15. 

Kumar R, Torres C, Yamamura Y, Rodriguez 1, Martinez M, Staprans S, Donahoe RM, Kraiselburd E, Stephens EB, Kumar A (2004) Modulation by morphine of viral set point in rhesus macaques infected with simian immunodeficiency virus and simian-human immunodeficiency virus. J Virol 78 11425-11428... 

In more recent studies, it has also demonstrated that administration of 2.5 or 10 mg/kg MDMA twice daily for 4 consecutive days resulted in neurotoxic effects in rhesus monkeys, with decreases in the density of serotonin uptake sites occurring at the higher dose (Johannessen et al. 1988). The neurotoxic effects of MDMA observed in primates included reductions in the content of serotonin and 5-HLAA and marked reductions in the cerebrospinal (CSF) concentrations of 5-HIAA levels that were observed following drug administration. These findings and other reports of neurotoxic effects of MDMA in primates (Ricaurte et al. 1988) raise serious concerns for its potential hazard in humans. 

The first rotavirus vaccine was a tetravalent rhesus rotavirus strain. It was licensed in the United States in 1998 and subsequently withdrawn from the market due to an association with intussusception. A pentavalent human-bovine reassortant rotavirus vaccine was approved by the FDA in February 2006. The exact mechanism by which the vaccine produces an immune response is unknown however, this live virus vaccine replicates in the small intestines and induces immunity. 

Harouse JM, Buckner C, Gettie A, et al. CD8+ T cell-mediated CXC chemokine receptor 4-simian/human immunodeficiency virus suppression in dually infected rhesus macaques. Proc Natl Acad Sci U S A 2003 100(19) 10977-10982. 

Napier C, Sale H, Mosley M, et al. Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human. Biochem Pharmacol 2005 71 163-172. 

Figure 7.2 Diurnal variation of extracellular dopamine in the non-human primate putamen. Dopamine concentrations (dm) as determined by high-pressure liquid chromatography of microdialysates obtained from the putamen of two rhesus monkeys across their 12 12 h lights-on (waking 7 00 am 7 00 pm) and lights off (sleep 7 00 pm-7 00 am) periods. Ten minute samples (2 pl/min sampling rate) were derived from nine individual 8 h sessions in each animal in which the sleep-wake state was monitored simultaneously by standard electrophysiological parameters.

Phase I and Phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey and cynomolgus monkey, Drug Metab. Dispos. 1995, 23, 1231-1241. 

The primary sources of PCP in humans include direct intake by way of diet, air, or water and through contact with PCP-contaminated materials (Uhl et al. 1986). It is now established that PCP is taken up by female rhesus monkeys via the skin from PCP-contaminated soils. Monkeys accumulated up to 24% of the PCP in contaminated California soils over a 24-h period (Wester et al. 

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