Human herpesvirus 6 and

Fogdell-Hahn, A., Soldan, S. S. and Jacobson, S. Association of chronic progressive neurological disease and ubiquitous viral agents lessons from human herpesvirus 6 and multiple sclerosis. Mol. Psychiatry 7 Suppl 2, S29-31, 2002. 

Hashimoto, K., Yasukawa, M., and Tohyama, M.,Human herpesvirus 6 and drug allergy. Curr. Opin. Allergy Clin. Immunol., 3, 255, 2003. 

Harma, M., Hockerstedt, K., LantenscMager, I. Human herpesvirus-6 and acute liver failure. Transplantation 2003 76 536—539... 

Compels UA, Macaulay HA (1995) Characterization of human telomeric repeat sequences from human herpesvirus 6 and relationship to replication. J Gen Virol 76 451-458 Goodbourn S, Didock L, Randall RE (2000) Interferons cell signalling, immune modulation, antiviral responses and viral countermeasures. J Gen Virol 81 2341-2364 Hengel H, Flohr T, Hammerling GJ, Koszinowski UH, Momburg F (1996) Human cytomegalovirus inhibits peptide translocation into the endoplasmic reticulum for MHC class I assembly. J Gen Virol 77 2287-2296... 

Watanabe H, Tohyama M, Kamijima M, Nakajima T, Yoshida T, Hashimoto K, lijima M. Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation. Dermatology 2010 221 17-22. 

Furlini G, Vignoli M, Ramazzotti E, Re MC, Visani G, La P (1996) A concurrent human herpesvirus-6 infection renders two human hematopoietic progenitor (TF-1 and KG-1) ceU lines susceptible to human immunodeficiency virus type-1. Blood 87(ll) 4737-4745... 

Over 20 infectious agents have been incriminated as etiologic agents for many the causal relationship has been disproved, and for others there is conflicting evidence. Human herpesvirus 6 (HHV-6) is currently the most likely causative virus. HHV-6 may initiate the autoimmune processes of MS in one of two ways. First, HHV-6 is structurally similar to myelin basic protein. When T cells become sensitive to HHV-6, the cells may attack myelin basic protein. Second, HHV-6 may directly stimulate the complement cascade, activating autoimmune processes.5 Infection with HHV-6 alone cannot fully explain MS, because HHV-6 is found in 75% of all people, but MS is much more rare. 

Acyclovir (Figure 49-2) is an acyclic guanosine derivative with clinical activity against HSV-1, HSV-2, and VZV, but it is approximately 10 times more potent against HSV-1 and HSV-2 than against VZV. In vitro activity against Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus-6 (HHV-6) is present but weaker. 

Aita, K., Jin, Y., Iris, H., Takahashi, I., Kobori, K., Nakasato, Y., Kodama, H., Yanagawa, Y., Yoshikawa, T., Shiga, J. Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection A case report and discussion. Human Pathol. 2001 32 887—889... 

Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ (2003) Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Ann Neurol 53 189-197. 

One report has presented evidence of a possible association between severe drug-induced erythema multiforme and reactivation of infection with human herpesvirus 6. The reactivation is thought to have contributed in some way to the development of allopurinol hypersensitivity reactions (20). 

Other herpesvirus infections that have been diagnosed using immunohistochemical methods include human herpesvirus 6 infection and Epstein-Barr viral infection.Immunohistochemistry has been used to identify EBV latent membrane protein-1 in cases of Hodgkin s lymphoma and post-transplant lymphopro-liferative disorder (Fig. 3.4). ... 

Isegawa, Y., Ping, Z., Nakano, K., Sugimoto, N., and Yamanishi, K. (1998). Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. J. Virol. 72, 6104-6112. 

French C. Novel, nonconsensus cellular splicing regulates expression of a gene encoding a chemokine-like protein that shows high variation and is specific for human herpesvirus 6. Virology 1999 262(1) 139-51. 

Compels UA, Nicholas J, Lawrence G, Jones M, Thomson BJ, Martin ME, Efstathiou S, Craxton M, Macaulay HA (1995) The DNA sequence of human herpesvirus-6 structure, coding content, and genome evolution. Virology 209 29 51... 

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