Other Herpesviruses

Carbocyclic gnanosine analogues have been described to inhibit HSV-1, HSV-2, VZV, CMV, and/or other herpesviruses [viz. HHV-6 (human herpesvirus type 6)],... 

The first step in identification of herpesvirus inhibitors that act via this mechanism is the evaluation of compounds for their ability to inhibit the protease enzyme. A number of assay formats have been used to examine the effect of herpesvirus protease inhibitors. This chapter describes four of these assays, and their relative merits and problems are discussed. In particular, the conditions for HCMV protease are described, with reference to modifications for other herpesvirus proteases where possible in the notes. A source of purified recombinant enzyme will be assumed, because a number of studies have described the use of Escherichia coli to express active herpesvirus proteases from a number of viruses, along with suitable purification methods (4-6). 

Other herpesvirus infections that have been diagnosed using immunohistochemical methods include human herpesvirus 6 infection and Epstein-Barr viral infection.Immunohistochemistry has been used to identify EBV latent membrane protein-1 in cases of Hodgkin s lymphoma and post-transplant lymphopro-liferative disorder (Fig. 3.4). ... 

Virus Virus Encoded Ligand Receptor Host Target Receptor Ligand Receptor / Ligand Function In vitro In vivo Activities Activities Homologs in Other Herpesvirus... 

Osborn JE (1982) Cytomegaloviruses and other herpesviruses. In Foster HL, Small JD, Fox JG (eds) The Mouse in Biomedical Research. Academic Press, New York, pp 267-293 Pass RF (2001) Cytomegalovirus. In Fields BN, Knipe DM, Howley PM (eds) Fields Virology. 3rd edn. 

Other herpesviruses of animals. Herpesviruses that have been found in squirrel and spider monkeys have been shown to have oncogenic potential. Other oncogenic herpesviruses include Marek s disease virus of chickens (206 p.209), the Lucke virus of frogs, and Herpesvirus sylvilagus of the cottontail rabbit. 

---