Human herpesvirus

Carbocyclic gnanosine analogues have been described to inhibit HSV-1, HSV-2, VZV, CMV, and/or other herpesviruses [viz. HHV-6 (human herpesvirus type 6)],... 

Furlini G, Vignoli M, Ramazzotti E, Re MC, Visani G, La P (1996) A concurrent human herpesvirus-6 infection renders two human hematopoietic progenitor (TF-1 and KG-1) ceU lines susceptible to human immunodeficiency virus type-1. Blood 87(ll) 4737-4745... 

Over 20 infectious agents have been incriminated as etiologic agents for many the causal relationship has been disproved, and for others there is conflicting evidence. Human herpesvirus 6 (HHV-6) is currently the most likely causative virus. HHV-6 may initiate the autoimmune processes of MS in one of two ways. First, HHV-6 is structurally similar to myelin basic protein. When T cells become sensitive to HHV-6, the cells may attack myelin basic protein. Second, HHV-6 may directly stimulate the complement cascade, activating autoimmune processes.5 Infection with HHV-6 alone cannot fully explain MS, because HHV-6 is found in 75% of all people, but MS is much more rare. 

Couty JP, Gershengom MC. Insights into the viral G protein-coupled receptor encoded by human herpesvirus type 8 (HHV-8). Biol Cell 2004 96(5) 349-354. 

Arvanitakis L, Geras-Raaka E, Varma A, Gershengom MC, Cesarman E. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 1997 385(6614) 347-350. 

Yang TY, Chen SC, Leach MW, et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi s sarcoma. J Exp Med 2000 191 (3) 445 154. 

Guo HG, Sadowska M, Reid W, Tschachler E, Hayward G, Reitz M. Kaposi s sarcoma-like tumors in a human herpesvirus 8 ORF74 transgenic mouse. J Virol 2003 77(4) 2631-2639. 

Fogdell-Hahn, A., Soldan, S. S. and Jacobson, S. Association of chronic progressive neurological disease and ubiquitous viral agents lessons from human herpesvirus 6 and multiple sclerosis. Mol. Psychiatry 7 Suppl 2, S29-31, 2002. 

Hashimoto, K., Yasukawa, M., and Tohyama, M.,Human herpesvirus 6 and drug allergy. Curr. Opin. Allergy Clin. Immunol., 3, 255, 2003. 

Esterling, B.A. et al., Psychosocial modulation of antibody to Epstein-Barr viral capsid antigen and human herpesvirus type-6 in HIV-1-infected and at-risk gay men, Psychosomat. Med., 54, 354, 1992. 

Epstein-Barr Virus and Kaposi s Sarcoma Herpesvirus/Human Herpesvirus 8... 

Acyclovir (Figure 49-2) is an acyclic guanosine derivative with clinical activity against HSV-1, HSV-2, and VZV, but it is approximately 10 times more potent against HSV-1 and HSV-2 than against VZV. In vitro activity against Epstein-Barr virus (EBV), cytomegalovirus (CMV), and human herpesvirus-6 (HHV-6) is present but weaker. 

Alford CA, Britt WJ (1993) In Roizman B, Whitley RJ, Lopez C (eds) The human herpesviruses. Raven Press, New York, p 227... 

An 84-year-old woman with polymyalgia rheumatica and a 79-year-old woman with undifferentiated connective tissue disease and leukocytoclastic vasculitis were given prednisolone 20 mg/day with subsequent dosage reductions. The first patient developed a raised purpuric rash and lymphedema of the left leg within 5 months and the second developed large purple nodules on the soles of her feet and the backs of her hands accompanied by periorbital and peripheral edema. Skin biopsies showed Kaposi s sarcoma, and both patients had raised IgG antibody titers to human herpesvirus-8. 

IARC (1997) Epstein-Barr virus and Kaposi s sarcoma herpesvirus/human herpesvirus 8. Lyon, International Agency for Research on Cancer (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 70). 

Fig 2. Expression of chemokines with and without N-terminal tags. Murine RANTES and human herpesvirus 8 vMIP-lB were expressed either as mature proteins (native) or with the addition of the residues MKKKWPR- to the N-terminus (K3) using the T7 based expression vector pET24d in either BL21(DE3) or BL21(DE3)pLysS cells. Each lane of this Coomassie stained SDS-polyacrylamide gel contains 0.04 OD600 units of the indicated strain following a 3-h induction. 

Interferon a Induction of celiuiar enzymes that interfere with virai protein synthesis Intracellular half-life of cidofovir diphosphate is 17-30 hours. Hepatitis B and C, human herpesvirus 8, papiiioma-virus 2-3... 

Malnati MS, Dagna L, Ponzoni M, Lusso P. Human herpesvirus 8 (HHV-8/KSHV) and hematologic malignancies. Rev Clin Exp Hematol 2003 7 375 405. 

Cattani P, Capuano M, Graffeo R, Ricci R, Cerimele F, Cerimele D, Nanni G, Fadda G. Kaposi s sarcoma associated with previous human herpesvirus 8 infection in kidney transplant recipients. / Clin Microbiol 2001 39 506-8. 

Li, H., and Nicholas, J. (2002). Identification of amino acid residues of gpl30 signal transducer and gp80 alpha receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6. / Virol. 76, 5627-5636. 

Alpha herpesvirinae Simplexvirus Human herpesvirus 1, herpes simplex virus... 

Frenkel N (1981) Defective interfering herpesviruses, hr The Human Herpesviruses—an Interdisciplinary Prospective (Nahmias A, Dowdle W, Scchinazy R, eds), pp 91—120. New York Elsevier-North Holland, hic. 

Epstein Barr viras (EBV) a gamma human herpesvirus. 

Aita, K., Jin, Y., Iris, H., Takahashi, I., Kobori, K., Nakasato, Y., Kodama, H., Yanagawa, Y., Yoshikawa, T., Shiga, J. Are there histopathologic characteristics particular to fulminant hepatic failure caused by human herpesvirus-6 infection A case report and discussion. Human Pathol. 2001 32 887—889... 

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