Maturation protein

Probably involved with NifS in iron-sulfur cluster synthesis Possibly accelerate MoFe protein maturation Unknown function... 

NifH and NifDK to GroEL. It is not clear from these data at which stage in the biosynthetic pathway just described GroEL might be involved in MoFe protein maturation, but it could be during P cluster insertion. 

COLLAGEN ILLUSTRATES THE ROLE OF POSTTRANSLATIONAL PROCESSING IN PROTEIN MATURATION... 

Protein Maturation Often Involves Making Breaking Covalent Bonds... 

Removal of these end-groups necessary for protein maturation is catalysed by a ferrous peptidase in both cases. The Fe(II) is relatively weakly bound and is a control element of protein maturation... 

Spring H, Brom M, Keppler D. Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome. Hepatology 2000 32(6) 1317-1328. 

Lill, R., Duftkiewitz, R., Elsasser, H.-R, Hausmann, A., Netz, D.J.A., Pierik, A.J., Stehling, O., Urzika, E. and Miihlenhoff, U. (2006) Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes, Biochim. Biophys. Acta, 1763, 652-667. 

Proteins synthesized at the rER (1) are folded and modified after translation (protein maturation see p. 230). They remain either in the rER as membrane proteins, or pass with the help of transport vesicles (2) to the Golgi apparatus (3). Transport vesicles are formed by budding from existing membranes, and they disappear again by fusing with them (see p. 228). 

The Golgi apparatus (3) is a complex network, also enclosed, consisting of flattened membrane saccules ( cisterns ), which are stacked on top of each other in layers. Proteins mature here and are sorted and packed. A distinction is made between the ds, medial, and trans Golgi regions, as well as a trans Golgi network (tGN). The post-translational modification of proteins, which starts in the ER, continues in these sections. 

The principles underlying protein synthesis and protein maturation (see pp. 230-233) can be summed up once again using the example of POMC ... 

Tovar J, Leon-Avila G, Sanchez LB, Sutak R, Tachezy J, van der Giezen M, Hernandez M, Muller M, Lucocq JM (2003) Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation. Nature 426 172-176... 

Proteins are targeted to their destination by signal sequences built into the polypeptide chain. These signals are usually located at the N-terminal end of the protein and are generally cleaved during protein maturation. 

Protein maturation results in a mature protein in the proteome (post-translational modifications are possible here). 

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