Human colorectal adenocarcinoma cells

Pretreatment of human T24 bladder or human colorectal adenocarcinoma cells with 5-FU followed by CGP 41251 showed a synergistic drug interaction in both cell lines (Fabbro et al., 1999). CGP 41251 or 5rFU were ineffective as a single agent against COLO 205 tumors up to 200 mg/kg/day p.o. and 75 mg/kg/week i. v., respectively. Combination of both compounds at these concentrations showed significant antitumor activity in this tumor model (Fabbro et al., 1999). 

The bacterial ghosts from Mannheimia hemolytica were repacked with DOX for targeted delivery to human colorectal adenocarcinoma cells (Caco-2). ° The system targeted to Caco-2 cells and the drug, released within the cells, was more cytotoxic than free DOX. This study demonstrated the specific drugtargeting properties of the bacterial ghosts. 

The compound lobeline reversed multidrug resistance in human colorectal adenocarcinoma cells in vitro by inhibiting P-glycoprotein (P-gp) activity. Lobeline, however, did not block breast cancer resistance protein-dependent mito-xantrone efflux (Ma and Wink 2008). 

Radomski, M.W., Jenkins, D.C., Holmes, L., and Moncada, S. (1991). Human colorectal adenocarcinoma cells differential nitric oxide synthesis determines their ability to aggregate platelets. Cancer Res. 51,60T5-(i(yi%. 

Siegert, A., Rosenberg, C., Schmitt, W.D., Denkert, C., and Hauptmann, S. (2002). Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion. Br. J, Cancer 86, 1310-1315. 

As an example, the data computed on colorectal adenocarcinoma cell line map (DLD1 HUMAN) (Demalte-Annessi et al., 1999 Pietrogrande et al., 2002). (Fig. 4.1a) are reported as follows. 

Human HT-29 colorectal adenocarcinoma cell line (ATCC, Manassas, VA). 

In vitro cell-based models have been developed to aid in the evaluation of ADMET properties of compounds to explore the influences of species differences. CaCo-2 cells, for example, constitute an immortalized line of heterogeneous human epithelial colorectal adenocarcinoma cells widely used to predict the absorption rates of candidate drug compounds across the intestinal epithelial cell barrier. Drug absorption rates are determined 21 days after CaCo-2 cell seeding to allow for monolayer formation and cell differentiation. 

Long, C.K.L. Lam, W.S. Chiu, L.C.M. Ooi, V.E.C. Sun, S.S.M. Wong, Y.-S. 2009. A rice bran polyphenol, eyeloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem. Pharmacol. 77 1487-1496. 

Caco-2 human epithelial colorectal adenocarcinoma cells... 

Thermally carbonized Human epithelial colorectal adenocarcinoma cell lines Caco-2, HT-29 Hydrophobin Class II protein conjugated to porous sihcon particles. Cell viabihty maintained and still able to allow drug permeation from the porous silicon particle to the cells Bimbo et al. (2012)... 

Faridi U, Sisodia BS, Shukla AK, Shukla RK, Darokar MP, Dwivedi UN, Shasany AK (2011) Proteomics indicates modulation of tubulin polymerizatirai by L-menthol inhibiting human epithelial colorectal adenocarcinoma cell proliferation. Proteomics 11 2115... 

Lee, Y, Geckeler, K. E. (2012). Cellular interactions of a water-soluble supramolecular polymer complex of carbon nanotubes with human epithelial colorectal adenocarcinoma cells. Macromolecular Bioscience, 12, 1060-1067. 

The Bowman-Birk trypsin-chymotrypsin inhibitor (BBI) from soybean has been proposed as anticarcinogenic drugs. The BBI inhibited the growth of human colorectal adenocarcinoma HT29 cells in vitro (Clemente et al., 2005). 

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