Colorectal adenocarcinoma

Adenocarcinoma, colorectal 2 Carcinoma, rhabdoid features, lung, 56 nonrhabdoid component... 

Adenocarcinoma, colorectal, 4 metastatic Carcinoma, small cell, bladder 34... 

As an example, the data computed on colorectal adenocarcinoma cell line map (DLD1 HUMAN) (Demalte-Annessi et al., 1999 Pietrogrande et al., 2002). (Fig. 4.1a) are reported as follows. 

It must be emphasized that the availability of the SMO and 2D autocovariance function methods as two independent statistical procedures to estimate the same parameter, in, the number of proteins, is a helpful tool to verify the reliability of the results obtained. In the case of the 2D PAGE map of colorectal adenocarcinoma cell line (DL-1) an excellent agreement was found between the values obtained from the SMO method—m = 101 10 and m = 105 10—and the 2D autocovariance function procedure—m = 104 10 (Pietrogrande et al., 2006a). 

Nakamura, T., Sakaeda, T., Ohmoto, N., Tamura, T., Aoyama, N. et al., Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas, Drug Metab. Dispos. 2002, 30, 4—6. 

Ch. 25). This means that mutations in these proteins that result in alterations in their regulatory properties can lead to oncogenesis. Ras in particular has been implicated in several human cancers [32]. It has been estimated that as many as 30% of all human cancers contain mutations in one of the three Ras genes. While the frequency of Ras mutations in some types of human cancer is very low, its frequency in certain cancers, such as squamous cell carcinoma, lymphatic cancers and colorectal adenocarcinoma, is very high. 

S. Badvie, A. Hanna-Morris, H. J. Andreyev, P. Cohen, S. Saini and T. G. Allen-Mersh, A field change of inhibited apoptosis occurs in colorectal mucosa adjacent to colorectal adenocarcinoma, J. Clin. Pathol., 2006, 59(9), 942. 

It has been postulated that wood dust carcinoma results from a multistep process Exposure causes loss of cilia and hyperplasia of the goblet cells and initiation of cuboidal cell metaplasia, followed (after a quiescent period) by squamous cell metaplasia. Decades later, cellular aplasia leads to nasal adenocarcinoma. The time between first occupational exposure to wood dust and the development of nasal cavity adenocarcinoma averages 40 years. Other cancers, including lung cancer, Hodgkin disease, multiple myeloma, stomach cancer, and colorectal cancer and lymphosarcoma, have been mentioned in relation to wood... 

Pretreatment of human T24 bladder or human colorectal adenocarcinoma cells with 5-FU followed by CGP 41251 showed a synergistic drug interaction in both cell lines (Fabbro et al., 1999). CGP 41251 or 5rFU were ineffective as a single agent against COLO 205 tumors up to 200 mg/kg/day p.o. and 75 mg/kg/week i. v., respectively. Combination of both compounds at these concentrations showed significant antitumor activity in this tumor model (Fabbro et al., 1999). 

Eberhart CE, Coffey RJ, Radhika A, et al. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994 107 1183-1188. 

In another study of 70 patients with colorectal adenocarcinoma, total TS mRNA concentration was higher in patients with homozygous triple tandem repeats (3R/3R), compared with those individuals with heterozygous tandem repeats (3R/2R) or homozygous double tandem repeats (2R/2R), although these data did not reach statistical significance (57). 

In another study involving patients with metastatic breast, colorectal and ovarian cancer, increased anti-sTn titers were correlated with better survival. Even if before treatment, elevated titers of antibodies against the mucin MUC1, were correlated with a poor response to immunotherapy, CTL precursors to the MUC1 were detected in carcinoma patients [208], A vaccine using 10 pg/ml MUC1-KLH mixed with Detox was injected s.c. in breast cancer patients treated with cyclophosphamide. A weak antibody response, and an ex vivo CTL response against HLA-matched adenocarcinoma cell lines were seen. No correlation with the clinical outcome was available [209],... 

Another vaccine, formulated by mixing irradiated cells from colon carcinoma cell lines with Detox was injected to patients with colorectal metastatic adenocarcinoma, with or without IL-la [212], The vaccine induced local toxicity, and fatigue which was increased in the group treated with IL-la. DTH occurred in both groups. No clinical response was available. 

Jansson, A., and Sun, X.-F. 1997. Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas. APMIS 705 730-734. 

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