Human cancer cell lines MCF-7

Computer programs dedicated to QSAR analyses or with a QSAR component have also been used to assist in the development of suitable QSARs for various applications. Using one such package, Samuel et al. were able to generate comparative molecular field analysis (CoMFA) models to predict the cytotoxicity of a series of dibenzyltin(IV) derivatives against two human cancer cell lines, MCF-7, a mammary carcinoma, and WiDr, a colon carcinoma. 

Human cancer cell lines (MCF-7, SW480, HCE7, Seg-1, Bic-1, and HL-60) Inhibiting the expression of cyclin B1, D1, A1, and P-catenin [127]... 

Brisdelli et al. (2013) investigated the effects of six lichen metabolites (diffractaic acid, lobaric acid, usnic acid, vicanicin, variolaric acid, protolichesterinic acid) on reactive oxygen species (ROS) level towards three human cancer cell lines, MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and HCT-116 (colon carcinoma). AU tested lichen compounds did not exhibit free radical scavenging activity using the l,l-diphenyl-2-picrylhydrazyl (DPPH) assay. The lichen metabolites did not significantly increase the intracellular ROS level and did not prevent oxidative injury induced by t-butyl hydroperoxide in tested cells. 

Hsu J-T, Ying C, Lan H-C. 1998. The effects of pesticides chlordane, dieldrin and endosulfan on the growth of human breast cancer cell lines MCF-7 and SK-BR-3. J Chinese Agri Chem Soc 36(6) 535-546. 

Lee ATC, Azimahtol HLP, Tan AN. Styrylpyrone derivatives (SPD) induces apopotosis in caspases-7-dependent manner in the human breast cancer cell line MCF-7. Cancer Cell Int 2003 3 1-8. 

Another peculiarity of the study is that the use of a biological system has allowed the authors to hypothesize a possible mechanism of action of the leachate as a mixture, hypothesis that could have been drafted on the basis of the only knowledge derived by chemical analysis. Researchers suggest that leachate inhibits cell proliferation at low doses probably inducing a reversible cell cycle arrest that becomes irreversible at high doses, probably due to leachate-induced oxidative stress. This activity is mainly due to the chemical compounds extracted in the aqueous phase. Similar effects were noticed by previous investigations on other human cells (human peripheral blood lymphocytes and a human breast cancer cell line, MCF-7) [31, 32], supporting the hypothesis that cells that survive the initial insult from leachate constituents maintains the potential to proliferate until the effects on cell metabolism lead to death. 

In contrast to P-gp and the MRP proteins, the breast cancer resistance protein (BCRP) contains six transmembrane domains and only one ATP-binding domain. It was first cloned from the breast cancer cell line MCF-7 selected in doxombicin, in the presence of the P-gp inhibitor verapamil. It is found in many human tissues, such as the placenta, small intestine, colon, and liver [133], It is localized to the apical membrane of epithelial cells of the small intestine and colon and to the bile canalicular membrane in the liver and is involved in reducing intestinal uptake, increasing hepatobiliary excretion, etc., leading to diminished oral bioavailability. cDNA sequences identical to BCRP and named MXR and ABCP, respectively, were independently isolated from human colon carcinoma cells and human placenta [134], BCRP requires... 

Brown, A.M.C., Jeltsch, J.M., Roberts, M. and Chambon, P. (1984). Activation of the PS2 gene transcription is a primary response to estrogen in human breast cancer cell line MCF-7, Proc. Natl. Acad. Sci. U.S.A., 81, 6344-6348. 

Diel, P., Olff, S., Schmidt, S. and Michna, FI. (2001). Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7, Planta Med., Aug, 67, 6, 510-514. 

Hsu, . C., Li-Chan, E. C. Y., and Jao, C. L. (2011). Antiproliferative activity of peptides prepared from enzymatic hydrolysates of tuna dark muscle on human breast cancer cell line MCF-7. Food Chem. 126, 617-622. 

Blom A, Ekman E, Johannisson A, et al. 1998. Effects of xenoestrogenic environmental pollutants on the proliferation ofa human breast cancer cell line (MCF-7). ArchEnviron ContamToxicol 34 306-310. 

Toward the above objectives, and also that of developing new methods for proteomic investigation, this laboratory has undertaken the identification of proteins whose abundances or primary structures are modified in drug-resistant strains of the human breast cancer cell line MCF-7. The parental cell line and several strains selected by exposure to different anti-cancer drugs were provided by K. H. Cowan (Eppley Cancer Center, University of Nebraska), P. Gutierrez and D. D. Ross, (Greenebaum Cancer Center, University of Maryland), and J. A. Moscow, (Department of Pediatrics, University of Kentucky). 

Bernardi, L. R., Biunno, f (2005). Protein profile changes in the human breast cancer cell line MCF-7 in response to SELIL gene induction. Proteomics 5, 2433-2442. 

The effect of various peptides and growth factors in small cell lung cancer cells has been reported by Bepler et al [121]. Four peptides isolated from completely different sources with structural similarities represent members of a new family of growth factors [121]. These peptides include 1) a 60 amino acid residue breast cancer- associated pS2 peptide isolated from human gastric juice and the culture media of the human breast cancer cell line MCF-7, 2) a 106 amino acid residue pancreatic spasmolytic polypeptide (PSP) isolated from porcine pancreas and 3) a 49 and 50 amino acid residue peptide predicted from a cyclic DNA isolated from the skin of frog, Xenopus laevis. 

Gokhale et al. [72] have synthesized a series of hydroxynaphthoquinone metal complexes as antitumor agents. The cytotoxic studies against the human breast cancer cell line MCF-7 revealed enhanced activities for the metal complexes. The highest activity is observed for the copper compound of lawsone, Fig. (12) (2-hydroxy-l,4-naphthoquinone). 

Yonezawa T, Katoh K, Obara Y. (2004) Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. Biochem Biophys Res Commun 314 805-809. 

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