Gene induction

SCHEME 10.5 Proposed pathway for the nonenzymatic conversion of BHTOOH to BHT-QM in keratinocytes. BHTOOH is oxidized to a peroxy radical that spontaneously loses oxygen. Two BHT phenoxy radicals then undergo disproportionation. 

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Honda K, Takaoka A, Taniguchi T (2006) Type I interferon gene induction by Hie interferon regulatory factor family of transcription factors. Immunity 25 349-360... 

Roles of STAT Proteins in Cytokine-lndncible and Constitutive Gene Induction... 

Gulick, P. Dvorak, J. (1987). Gene induction and repression by salt treatment in roots of the salinity-sensitive Chinese Spring Wheat and salinity-tolerant Chinese Spring x Elytrigia elongate amphiploid. Proceedings of the National Academy of Sciences, USA, 84, 99-103. 

The increased dopamine hypothesis is supported by findings of gene induction in the target areas and the indications that individual differences in dopamine receptors and transporters may underlie impulsive and addictive behaviour in humans. Studies in knock-out mice have, however, provided evidence for complex roles of 5-HT in these processes. 

Kukielka GL, Smith CW, LaRosa GJ, et al. Interleukin-8 gene induction in the myocardium after ischemia and reperfusion in vivo. J Clin Invest 1995 95(1) 89-103. 

Waxman DJ. P450 gene induction by structurally diverse xenochemicals central role of nuclear receptors CAR, PXR, and PPAR1. Arch Biochem Biophys 1999 369 11-23. 

Zhou, H. R. and Pestka J.J. Deoxynivalenol-induced apoptosis mediated by p38 MAPK-dependent p53 gene induction in RAW 264.7 macrophages. The Toxicologist 72, 330, 2003. 

Gibson, G.G., Plant, N.J., Swales, K.E., Ayrton, A. and El-Sankary, W. (2002) Receptor-dependent transcriptional activation of cytochrome P4503A genes induction mechanisms, species differences and interindividual variation in man. Xenobiotica, 32 (3), 165-206. 

Schulze-Osthoff, K., Beyaer, R., Vandevoorde, V., Haegeman, G.,and Fiers, W., 1993, Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene inductive effects of TNF, MBO/. 12 3095-... 

Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC (1999) The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades MSKl as a potential histone H3/HMG-14 kinase. Embo J 18(17) 4779-4793 Trivier E, De Cesare D, Jacquot S, Pannetier S, Zackai E, Young I, Mandel JL, Sassone-Corsi P, Hanauer A (1996) Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Nature 384(6609) 567-570... 

Van Gelder How do you reconcile the action spectrum data with the vitamin A-depletion data that we have presented As the perspective for this, in Neurospora, entrainment of the clock is resistant to vitamin A metabolic defects and in Drosophila it is resistant to vitamin A depletion. We found a similar result in the mammal with near-complete vitamin A depletion of the eye, and no attenuation in the response, as measured by immediate-early gene induction in the SCN. 

Near-total vitamin A depletion of the eye does not significantly decrease photic signalling to the SCN, as measured by photic immediate-early gene induction... 

It is theoretically possible that cryptochromes do not function as photopigments, but are required either for the production of another photopigment, or for the signal transduction pathway of another photopigment. Such a pigment would need to be fully resistant to severe vitamin A depletion (since photic immediate-early gene induction in the SCN is fully preserved in RBP I mice but lost in mice) and so is unlikely to be opsin-... 

Van Gelder We have increased it up to about 500 lux, where we find a few animals show entrainment where they didn t under dim light, but the majority of animals remain unresponsive. This is not the same level of light intensity that they are subjected to in the photic gene induction studies. We haven t taken the intensity up to this level yet in the behavioural studies. 

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