Horrobin

D. F. Horrobin, Prostaglandins, Eeukot. Essent. Fatty Acids 31, 181 (1989). 

KRUGER M c and HORROBiN D F (1997) Calcium metabolism, osteoporosis and essential fatty acids a review. Prog Lipid Res 36, 131-51. 

Finally, an intriguing possible future therapy arises from a radical idea of Horrobin (2001) that schizophrenia is a nutritional disorder linked to a decreased intake of essential polyunsaturated fatty acids. Recent 31P-MRS studies have shown changes in plasma membrane phospholipids in the neocortex of unmedicated schizophrenics, which would have deleterious consequences on synaptic neurotransmission (Fukuzako, 2001). A clinical trial with the co6 fatty acid derivative ethyleicosa-pentaenoic acid (LAX-101) in patients who had been unresponsive to clozapine, reported that a daily dose of 2g LAX-101 gave a 26% improvement in symptoms over 12 weeks compared with 6% with placebo (Peet and Horrobin, 2001). Maybe in... 

Horrobin D (2001). The Madness of Adam and Eve. Bantam Press, London. 

Peet M and Horrobin DF (2000). Eicosapentaenoic acid in the management of treatment-unresponsive schizophrenia. Journal of Psychopharmacology, 14(Suppl. 3), A63. 

Many models have been developed that deal with the sorption properties of wood in the presence of moisture these have been discussed in a number of works (e.g. Skaar, 1972 Siau, 1984). They can be approximately divided into sorption models, such as the Brunauer-Emmett-Teller (BET) model, or solution models (such as the Hailwood-Horrobin, H-H, model). The sigmoidal shapes of sorption or desorption isotherms can be deconvoluted into two components. These are often taken to represent a monomolecular water layer (associated with the primary sorption sites, OH groups), and a multilayer component where the cell wall bound water molecules are less intimately associated with the fixed cell wall OH groups. 

Horrobin, D.F. Modem biomedical research an internally self-consistent universe with little contact with medical reality Nat. Rev. Drug Disc. 2003, 2, 151-154. 

Bugaut, M. In vivo incorporation of lau-ric acid into rat adipose tissue triacy-Iglycerols. Lipids 1989 24(3) 193-203. Huang, Y. S., B. A. Nassar, and D. F. Horrobin. The prostaglandin outflow from perfused mesenteric vasculature of rats fed different fats. Prostaglandins Leukot Essent Fatty Acids 1989 35(2) 73-79. 

Huang, Y. S., P. Redden, X. Lin, R. Smith, S. MacKinnon, and D. F. Horrobin. Effect of dietary olive oil non-glyceride fraction of plasma cholesterol level and live phospholipid fatty acid composition. Nutr Res 1991 11(5) 439-448. 

Murakami K. and Routtenberg A. (2003). The role of fatty acids in synaptic growth and plasticity. In Peet M., Glen L., and Horrobin D. F. (eds.), Phospholipid Spectrum Disorders in Psychiatry and Neurology. Marius Press, Camforth, Lancashire, pp. 77-92. 

Schizophrenia Increased Decreased Beneficial (Horrobin, 2003b McNamara et al., 2006)... 

Horrobin D. F. (2003a). Are large clinical trials in rapidly lethal diseases usually unethical Lancet... 

Horrobin D. F. (2003b). Omega-3 fatty acid for schizophrenia. Am. J. Psychiat. 160 188-189. 

Cunnane, S.C., McAdoo, K.R., and Horrobin, D.F. 1987. Horrobin, iron intake influences essential fatty acids and lipid composition of rat plasma and erythrocyts. J. Nutr. 117, 1514-1519. 

Jiang, W.G., Hiscox, S., Hallett, M.B., Scott, C., Horrobin, D.F., and Puntis, M.C., Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-lino lenic acid, Br. J. Cancer., 71, 744, 1995. 

Oliwiecki, S., Burton, J.L., Elies, K., and Horrobin, D.F., Level of essential and other fatty acids in plasma and red cell phospholipids from normal controls and patients with atopic eczema, Acta Derm. Venereol. (Stockh), 71, 224,1991. 

Manku, M.S., Horrobin, D.F., Morse, N., Kyte, V., and Jenkins, K., Reduced levels of prostaglandin precursors in the blood of atopic patients defective delta-6-desaturase function as a biochemical basis for atopy, Prostaglandins Leukot. Med., 9, 615, 1982. 

Morse, P.F., Horrobin, D.F., Manku, M.S. etal., Meta-analysis of placebo-controlled studies of the efficacy of Epogam in the treatment of atopic eczema. Relationship between plasma essential fatty acid changes and clinical response, Br. J. Dermatol., 121, 75, 1989. 

Horrobin, D.F., Essential fatty acids in clinical dermatology, J. Am. Acad. Dermatol., 20, 1045, 1989. 

Horrobin, D.F., Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic... 

Horrobin, D.F. 2000. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr 71 367-372. 

Onagraceae Oenothera biennis L. Horrobin and Manku (1983) Puolakka and Makarainen (1985)... 

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