Hormones somatropin

Recently, a CE method was introduced for impurity profiling of the human growth hormone somatropin produced by the recombinant DNA (rDNA) technology. ... 

Cheng YH, Dyer M, Jabbal-Gill I, et al. Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations. Eur J Pharm Sci 2005 26 9-15. 

The 10-year-old male client is receiving the growth hormone somatropin (Humatrope). Which signs or symptoms would warrant intervention by the nurse ... 

These hormones cause few adverse reactions when administered as directed. Antibodies to somatropin may develop in a small number of patients, resulting in a failure to experience response to therapy, namely, failure of the drug to produce growth in the child. Some patients may experience hypothyroidism or insulin resistance Swelling, joint pain, and muscle pain may also occur. 

Genotropin Somatropin Pharmacia Upjohn Short stature in children due to growth hormone deficiency... 

Humatrope Somatropin Eli Lilly Human growth hormone deficiency in children... 

Somatropin is a protein having the structure (191 amino acid residues) of the major component of growth hormone produced by the human pituitary. Somatropin is produced by a method based on recombinant DNA technology. Recently the results of a collaborative study between 14 laboratories have been reported, in which a new CE method was compared with the existing test for isoform distribution by isoelectric focusing. The CE method was found to be superior to the method of isoelectric focusing. As a result CE is applied for identification... 

A), 3.8 billion Amgen s white blood cell stimulant, Neupogen (filgrastim), 3.0 billion interferon pia (Avonex for multiple sclerosis), 2.2 billion human growth hormone (HGH), 1.8 billion recombinant hepatitis B vaccine ( 1.0 billion) somatropin (Humatrope and Neutropin), 0.9 billion and cerezyme/ceredase (alglucerase), 0.6 billion. 

The anabolic effects of somatropin are mediated by somatomedins or insulin-like growth factors. Somatropin is a synthetic polypeptide identical to the natural occurring growth hormone which stimulates longitudinal growth. Only preparations made with recombinant DNA technology are used nowadays. They can consist of 191 amino acids as growth hormone itself or 192 amino acids with one extra methionine. Somatropin is employed in the treatment... 

F. Role in therapy Micromedex notes that like somatropin (rDNA origin), somatrem is effective in the treatment of children with documented defidenq of growth hormone its effectiveness in constitutional short stature remains to be determined. Somatrem can be considered to be equal to somatropin in efficaq , but because of the increased incidence of immunogenic effects resulting in neutralizing antigrowth hormone antibodies seen with somatrem, it will likely take a secondary role to recombinant somatropin products in therapy. 

Recommended dosage and monitoring requirements The recommended dosage of somatropin for growth-hormone deficiency varies with the product and should be individualized. Therapy for children... 

F. Role in therapy Somatropin (rDNA origin) is a safe alternative to growth hormone derived from human pituitary glands, which carries the risk of viral contamination. Pituitary-derived growth hormone has been withdrawn from the... 

Somatropin [rDNA origin] for injection [FDA] Human growth hormone, recombinant [SY] hGH [SY]... 

Somatrem [FDA USAN INN BAN JAN] Somatropin (human), A-L-methionyl- [CAS] Growth hormone, A-L-methionyl- [CAS] Growth hormone (human), A-L-methionyl-[CAS]... 

Growth hormone is a 191-amino-acid peptide with two sulfhydryl bridges. Its structure closely resembles that of prolactin. In the past, medicinal GH was isolated from the pituitaries of human cadavers. However, this form of GH was found to be contaminated with prions that could cause Creutzfeldt-Jakob disease. For this reason, it is no longer used. Somatropin, the recombinant form of GH, has a 191-amino acid sequence that is identical with the predominant native form of human GH. 

Humatrope (somatropin) [E. coli-expressed recombinant polypeptide hormone] Eli Lilly Lyophilized 5 mg single-dose vials... 

Established indications for somatropin (growth hormone) include growth hormone deficiency in children, Turner s syndrome, Noonan s syndrome, and renal insufficiency in children. Other well-studied indications include idiopathic short stature, adult growth hormone deficiency, osteoporosis, and catabolic states associated with acute and chronic illness and injury. Body composition, respiratory muscle function, physical strength, and height improved in a 12-month trial of somatropin in 54 children with Prader-Willi syndrome (1). 

The effect of somatropin on cardiovascular risk is complex, as growth hormone reduces visceral fat and total cholesterol and increases FfDL cholesterol concentrations (7-9). 

Somatropin extracted from cadaveric human pituitaries was used to treat growth hormone-deficient patients until several cases of the fatal degenerative neurological disorder Creutzfeldt-Jakob disease were reported in the mid-1980s. Of 267 cases of iatrogenic Creutzfeldt-Jakob disease, 139 were caused by human cadaver-derived somatropin (SEDA-25, 479). 

This disease develops when an abnormal prion protein present in the cadaveric material induces a cascade of conformational changes in host protein. Creutzfeldt-Jakob disease in recipients of somatropin differs from the sporadic form, in that it usually presents with cerebellar signs rather than cognitive impairment, and also in the prominence of prion protein amyloid plaques in nervous tissue (18). In a review, 139 cases of Creutzfeldt-Jakob disease were identified worldwide in people treated with cadaveric somatropin before recombinant human growth hormone became available in the mid-1980s (19). The prevalence of this fatal neurodegenerative condition in recipients of somatropin ranges from 0.3% in the USA to 4.4% in France. Creutzfeldt-Jakob disease has been reported to start at 4-30 years after therapy with cadaveric somatropin (18), so that further cases are anticipated and continue to be reported (20). 

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