Intranasal delivery

M. Singh, M. Briones, and D. T. O Hagan. A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. J Control Release 70 267-276 (2001). 

Frey WH, Liu J, Thorne RG, et al Intranasal delivery of 125 1-labeled nerve growth factor to the brain via the olfactory route, in Research Advances in Alzheimer s Disease and Related Disorders. Edited by Iqbal K, Mortimer JA, Winblad B, et al. Chichester, England, Wiley, 1995, pp 329-335 Eriedman E, Gershon S Effect of lithium on brain dopamine. Nature 243 520-521, 1973... 

It is rapidly absorbed into the systemic circulation following intranasal delivery. It stimulates the release of LH and FSH from the anterior pituitary resulting in a temporary increase of ovarian steroidogenesis. After 2 to 3 days of daily administration, the pituitary becomes refractory to further stimulation. LH/ FSH release is inhibited within 10 days and is followed by a decrease in secretion of gonadal steroids within 2 to 6 weeks. 

Parenteral calcitonin (32 aa) formulations are used to regulate calcemia. Intranasal delivery of calcitonin, a potentially convenient alternative, produces low bioavailability and is not useful as such. Permeation enhancers, including mixed micelle formulations composed of either... 

STDHF has also been shown to enhance intranasal delivery of insulin. The bioavailability of insulin (51 aa) formulated as a nasal drop or spray containing STDHF was 16% to 47% in healthy volunteers [22].The... 

Li, L., I. Nandi, and K. H. Kim. 2002. Development of an ethyl laureate-based microemulsion for rapid-onset intranasal delivery of diazeparhnt. J. Pharm.237 77-85. 

Chou, K.J., and M.D. Donovan. 1997. Distribution of antihistamines into the CSF following intranasal delivery. Biopharm Drug Disp 18 335. 

Martinez, J. A., Francis, G., Liu, W., Pradzin-sky, N., Fine, J., et al. (2008) Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis. Neuroscience. 

Lawrence, D. 2002. Intranasal delivery could be used to administer drugs directly to the brain. Lancet 359 1674. 

Frey, W. H., Liu, J., Thorne, R. G., and Rahman, Y. E. (1995), Intranasal delivery of 125I-labelled nerve growth factor to the brain via the olfactory route, in Iqbal, K., Mortimer, J. A., Winbald, B., and Wisniewski, H. M., Eds., Research Advances in Alzheimer s Disease and Related Disorders, Wiley, New York, pp. 329-335. 

Cheng, Y.-H., Dyer, A. M., Jabbal-Gill, I., Hinchcliffe, M., Nankervis, R., Smith, A., and Watts, P. (2005), Intranasal delivery of recombinant human growth hormone (somatro-pin) in sheep using chitosan-based powder formulations, Eur. J. Pharm. Sci., 26, 9-15. 

El-Hameed, M. D. A., and Kellaway, I. W. (1997), Preparation and in vitro characterization of mucoadhesive polymeric microspheres as intranasal delivery systems, Eur. J. Pharm. Biopharm., 44, 53-60. 

The pharmacokinetics of intranasal lorazepam compared with oral administration have been evaluated in 11 volunteers in a randomized, crossover study (20). Lorazepam had favorable pharmacokinetics for intranasal administration compared with standard methods. Intranasal delivery could provide an alternative non-invasive delivery route for lorazepam. 

MK-678 (L363,586) (58), a cyclic hexapeptide, lowers fasting and postprandial hyperglycaemia in IDDM patients, after i,v, or intranasal delivery [301], and, taken intranasally at bedtime, can abolish the morning... 

Law, S.L. Huang, K.J. Chou, H.Y. Preparation of desmopressin-containing liposomes for intranasal delivery. J. 

Ilium L, Watts P, Fisher AN, Hinchcliffe M, Norbury H, Jabbal-Gill I, Nankervis R, Davis SS. Intranasal delivery of morphine. J Pharmacol Exp Ther 2002 301(l) 391-400. 

Park JS, Oh YK, Yoon FI, et al. In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA. / Biomed Mater Res 2002 59(1) 144-151. 

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