Heterocyclic compounds of nitrogen

The compd flashes on a hot plate. The triazole has a heat of combustion of 2406cal/g, and a AH of 1009cal/g Refs 1) Beil, not found 2) H.P. Burchfield et al, Research and Development... Explosives. .. Heterocyclic Compounds of Nitrogen. . Progress Rept No 3, Naugatuck Chemical Div,... 

Syntheses of heterocyclic compounds of nitrogen (CXVI). J. Pharm. 

It may be noted that the chemical properties and reactivity of nitrogen ring compounds are different from those of oxygen-containing rings. Heterocyclic compounds of nitrogen are basic, and some are strong bases. 

Heterocyclic compounds of nitrogen and oxygen can be analyzed by GC techniques using a flame ionization detector. Alternatively, these substances may be analyzed by GC/MS or FTIR spectroscopy. Analysis of pyridine in gronndwater, soil, and haz-ardons wastes may be performed by GC/MS in accordance to EPA Method 8270 (U.S. EPA 1986). A fnsed-silica capillary colnmn snch as DB-5 (J W Scientific) or eqnivalent is snitable for the pnrpose. 

It is less toxic relative to pyrrole and other five-membered heterocyclic compounds of nitrogen. Intraperitoneal administration of imidazole caused somnolence, muscle contractions, and convulsions in mice. The oral LD50 value in mice is in the range 900 mg/kg. 

Takahashi, T. Satake, K. Nomura, N. Yoshikawa, K. Sawata, M. Syntheses of heterocyclic compounds of nitrogen. LXII. Yakugaku Zasshi 1952, 72,42-45 Chem. Abstr. 1952, 46, 67054. 

Bertinotti, F., G. Giacomello, and A. M. Liquori. 1956. The Structure of Heterocyclic Compounds Containing Nitrogen. I. Crystal and Molecular Structure of s-Tetrazine. Acta Cryst. 9, 510. 

Carbonylative ring-expansion reactions catalyzed by transition metal complexes provide efficient methods for the synthesis of heterocyclic compounds, especially nitrogen heterocycles. 

Most of the heterocycles are known hy their trivial names, e.g. pyridine, indole, quinoline, thiophene and so on. However, there are some general rules to he followed in a heterocycle, especially in the use of suffixes to indicate the ring size, saturation or unsaturation as shown in the following table. For example, from the name, pyridine, where the suffix is -ine, one can understand that this heterocyclic compound contains nitrogen, has a six-memhered ring system and is unsaturated. 

The Gas-Phase Thermal and Photochemical Decomposition of Heterocyclic Compounds Containing Nitrogen, Oxygen or Sulfur S. Braslavsky and J. Heicklen, Chem. Rev., 1977,77,473-511. 

Heterocyclic molecules account for over half of all known organic compounds. A large proportion of these heterocyclic compounds contain nitrogen indeed many classes of important natural products, as well as a majority of synthetic drugs, dyes, etc. are based on nitrogen heterocycles. Advances in Nitrogen Heterocycles reflects the importance of this area, by providing up-to-date accounts of key research. 

The activity in the field of ferroceno heterocyclic compounds of the type 1 has been even less in the case of oxygen-containing compounds than it was with nitrogen-containing compounds. As might be anticipated, the first two examples of this class of compounds were an anhydride and a lactone. Thus treatment of ferrocene-1,2-di carboxylic... 

Mochida et al. (76) report that in carbonizations of several heterocyclic compounds containing nitrogen, sulphur and oxygen, the presence of the heteroatoms markedly affects optical texture of resultant cokes. When co-carbonized with aluminium chloride the heteroatoms exert a less marked effect where heteroatom evolution becomes important. Again, Mochida et al. (76) emphasise that the rate of the carbonization process, by influencing viscosity, is dominant in determining optical textures of cokes and related physical properties, i.e. CTE. 

Creosote. The major portion of creosote is derived from coal and is a complex mixture of aromatic hydrocarbons with condensed ring systems. The remaining components are tar acids, which are phenolic derivatives of these compounds, and tar bases, which are heterocyclic compounds containing nitrogen plus some neutral oxygenated compounds. At least 200 chemical compounds have been identified in coal-tar creosote, but many of these are present in small amounts. The chemical composition is variable, but some idea of a typical creosote is given in Table I (2). 

In aliphatic heterocyclic compounds, the nitrogen atom is part of a saturated heterocyclic ring and the lone pair of electrons is available for reaction with protons (e.g. piperidine, Figure 3.19). Compounds of this type are similar in base strength to their open-chain aliphatic counterparts with typical pK3 values of 8-9. 

V Lopez-Avila, J Benedicto, C Yan. Determination of selected heterocyclic compounds containing nitrogen, oxygen, and sulfur by capillary electrochromatography. J High Resol Chromatogr 20 615-618, 1997. 

Z. Gamba and H. Bonadeo, Chem. Phys. Lett., 69, 525 (1980). Intermolecular Potentials for some Crystals of Heterocyclic Compounds Containing Nitrogen. 

As the title denotes, this chapter deals with the conversion of carbohydrate derivatives into five-membered heterocyclic compounds containing nitrogen. The types of target compounds are (1) hydroxymethylpyrrolidines, (2) carboxypyrrolidines, (3) aralkyl pyrrolidines and... 

Many heterocyclic compounds of complex structure occur in nature, and many have been synthesized. Most of the basic nitrogenous substances which occur in plants and are known as alkaloids are heterocyclic compounds. When coal is subjected to destructive distillation a part of the nitrogen present is converted into ammonia, and a part into cyclic compounds which contain nitrogen as a constituent of the ring. Heterocyclic compounds are also obtained from DippePs oil, which is a product of the distillation of bones. From these sources are obtained pyridine, C5H5N, picoline, CH3.C5H4N, quinoline, C9H7N, etc.. ... 

A great variety of heterocyclic compounds containing nitrogen or other elements have been investigated, but only a few will be described here. 

Recently, a variety of heterocyclic compounds containing nitrogen and sulfur atoms have been developed as useful and practical agrochemicals. Our attention was directed to these heterocycles as screening targets to create novel bioactive compounds (7). 

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